<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08160

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMIMDNSKTTSKTTLLKLMLLRAWKERWTDCQWGINVKTILTRGVSGDVYNLADAIIQQAVVGSGANMLFLSYLKHSLCAHLISHAAVLNRIAKYDQFDKHHCLIALLDFLKSIIDGVTCRGKQEEAILTKATVSLVHWLLQIYECVLQSYAEDRTLQPEEEEVVQRVAVVLERIVENPFLLGVLSIGKCDDPELFIALQKRFNGISNLTLTTGYVANVGGGNANSLTVTDCMRKLVLLEVDALEMRPFDGGKVEPITYSLQPLIAIEVLLNPMCDTQQYVAQLINLKRLKGFTYARLYCELMRGCLIALNNVEGTAKESLLCAFAFIKVPHILHQLHAKTNGAEQQDEATSATYSVEVLEAFELLLQDTPVLDYMDMKCACNVVECLLKEMVKLQLLTDTHVKQLVALREPVTAGLHKLDANSAPLTMMLKFVFRVESPLAGILKALSTDCSKVQDALLAMLCQVLTGNSLDLVLSVASVEGKFRAFISGLLKCNDYAKQATTAEIGKAPTTRSALFDVSFMILASIAQSYGSDVILAEGGNSFFEKWVRDYMVERKKTKSPMTMVKQADPMVLEELIMAMNNSEGMYVGLKASSLRWEDICYTIPALVHQVLMAWESESIAPLEIKKMLDGLKAYFSTFAVCAASWLCAYMQMVRQDEQLKPMNMVQQLCSALAGPLADEWQQQDYCKERFGLMGQIVRRMQQEFLRTPQVNPKLRALFPSQQQHVVSHLPLEEQFEEAWKAIAERGWLPIETTFLLDTLLQSCGPAWLVEKLIGKLFVCKYVRDLNKTMDIIFAIMHLDIERCTIALLSQLVPMMLLSKAQTPEIVDPQSRVLAKLCVYCIIVTMETSLTATKKRTRGTASSDLEDLDALCTSAKLRKIELDGMGVGCTEAASAGGASGTEFSLDSALEPTASAWASEAASIATLKEPLQSCLQTLFRTFAQHIATDELSPKVYFVFQFLSLLVESGRERIMCVLKLLPNGLVQSLLKINATDEMTVGLILRLYDLNTPSGRQFAMSDICLLRNIQMRKESIKL
Length1036
PositionTail
OrganismAnopheles merus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy0.159
Instability index41.93
Isoelectric point5.87
Molecular weight115433.95
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08160
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     236.47|      69|     166|     758|     827|       3
---------------------------------------------------------------------------
  524-  551 (27.03/ 9.25)	LASIAQSYGSDVILAE.GGNSFFEKWVRD...............................................
  758-  826 (119.69/79.63)	LDTLLQSCGPAWLVEKLIGKLFVCKYVRD.LNKTMDIIFAIMHLDI....ER..CTIALLSQLVPMMLLSKAQTPE
  927-  996 (89.74/56.88)	LKEPLQSC.....LQTLF.RTFAQHIATDeLSPKVYFVFQFLSLLVesgrERimCVLKLLPNGLVQSLLKINATDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.53|      17|      98|     552|     568|       6
---------------------------------------------------------------------------
  552-  568 (31.58/21.62)	Y..MVERKKTKSPMTMVKQ
  651-  669 (27.95/18.29)	YmqMVRQDEQLKPMNMVQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.06|      21|     570|      20|      40|       8
---------------------------------------------------------------------------
   20-   40 (41.84/23.98)	LRAWKERWTDCQWGIN..VKTIL
  591-  613 (34.22/18.48)	LKASSLRWEDICYTIPalVHQVL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08160 with Med24 domain of Kingdom Metazoa
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