<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08153

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFHKARNKDEYLGFVARLILHVREMNTKHKNQQNAAAAAAAAAQQAQQDGGGNSSQQGGGGGGGGSGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGAGQASNLLHSLRPQMQMGGMGGPMQGNRVGMGPGNQMGGMMGGPNQMQGPGAGMVGGMPGQMGVGMGPGGMSGGKIVGMGGQQQQMAQLNAMQVNQMQQAQQQQQQQQGGMSQPQQQQQQQQQQQGGIAQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQNAMGGQQMGTVGGTMNAGNQMGQMVGANAGMNPQAMGMASNQVVRQQQLQQQGMGQVQMGLGPGQMGQLTMGPGGVVGPAGGGGVMGPGPNQMLGAGGAGGPGAGQQGNFVGMGANAMVRKPPEMMPGGNVYPGSGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMGGVAQRSTIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYRALTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILSNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAVSSSLQAATGNHTLQRTFRPCLEALFGPDIKNLPPPAKQSRLALDDTGAAGGTGGGVTTGGATTTTTSTTTAAATTGSASSTTSTTASSTTAPQEIPHILQGEIARLDQKFKVSLDQCAISGTRTIKLICWLDDKNLPCVPPVAVTIPEDYPSTAPSCSLIEQEYNATPFLILVQKSLMARICKLPGLFTLSHLLDTWEMSVRQACSPNPTIVAPTGTSVLLGM
Length838
PositionTail
OrganismAnopheles merus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.02
Grand average of hydropathy-0.422
Instability index50.17
Isoelectric point9.18
Molecular weight86194.03
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08153
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     240.47|      30|      32|     159|     189|       2
---------------------------------------------------------------------------
  126-  146 (37.91/ 6.52)	P.QMmgQ.....M.............G..VGPGGPMGGQ...MGG
  159-  189 (70.02/21.59)	P.QM..Q.....M.GGMGGPMQGNrVG..MGPGNQMGGM...MGG
  190-  227 (42.04/ 8.19)	PnQM..QgpgagMvGGMPGQM.G..VG..MGPGGMSGGKivgMGG
  305-  337 (42.69/ 8.46)	A.QL..Q....nQ.NAMGGQQMGT.VGgtMNAGNQMGQM...VGA
  357-  382 (47.81/10.53)	Q.QL..Q.....Q.QGM.GQVQ...MG..LGPG.QMGQL...TMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     132.12|      20|      22|     384|     403|       3
---------------------------------------------------------------------------
  384-  403 (43.28/14.15)	GGVVGPAGG..GGVMGPGPNQM
  407-  428 (28.31/ 6.34)	GGAGGPGAGqqGNFVGMGANAM
  438-  457 (30.41/ 7.44)	GGNVYPGSG..GAVRSVTPNNF
  463-  481 (30.12/ 7.29)	SPSVPSPVG..PGAHGP.PSHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.65|      22|     184|      85|     116|       4
---------------------------------------------------------------------------
   85-  106 (42.51/ 8.12)	QQAQQDGGGNSSQQGG.....GGGGGG
  265-  291 (40.14/11.47)	QQQQQQQGGIAQGQGGpvqqmGVGPGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.82|      12|      15|     672|     684|       5
---------------------------------------------------------------------------
  672-  684 (18.34/13.32)	TTGGAtTTTTSTT
  689-  700 (21.48/10.73)	TTGSA.SSTTSTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.92|       9|      16|     493|     503|       6
---------------------------------------------------------------------------
  493-  503 (14.69/10.23)	SPNPHMggVAQ
  821-  829 (19.23/ 6.24)	SPNPTI..VAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.87|      17|      23|     595|     614|       7
---------------------------------------------------------------------------
  594-  613 (24.49/19.86)	ALTSqlgSIRETPTNN.......PLVE
  614-  637 (23.38/10.67)	AVSS...SLQAATGNHtlqrtfrPCLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.76|      10|      38|     482|     492|       8
---------------------------------------------------------------------------
  482-  492 (17.23/11.30)	GQMIPSPaLIP
  522-  531 (20.53/ 9.27)	GGAVPSP.LNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.11|      16|      16|     548|     563|       9
---------------------------------------------------------------------------
  548-  563 (26.96/20.41)	IEPLKRMIAKMENDDI
  566-  581 (25.15/18.55)	IAKMKRLLEILSNPSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08153 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFH
2) PPAKQSRLALDDTGAAGGTGGGVTTGGATTTTTSTTTAAATTGSASSTTSTTASSTTAPQE
3) VREMNTKHKNQQNAAAAAAAAAQQAQQDGGGNSSQQGGGGGGGGSGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGAGQASNLLHSLRPQMQMGGMGGPMQGNRVGMGPGNQMGGMMGGPNQMQGPGAGMVGGMPGQMGVGMGPGGMSGGKIVGMGGQQQQMAQLNAMQVNQMQQAQQQQQQQQGGMSQPQQQQQQQQQQQGGIAQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQNAMGGQQMGTVGGTMNAGNQMGQMVGANAGMNPQAMGMASNQVVRQQQLQQQGMGQVQMGLGPGQMGQLTMGPGGVVGPAGGGGVMGPGPNQMLGAGGAGGPGAGQQGNFVGMGANAMVRKPPEMMPGGNVYPGSGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMGGVAQRSTIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREK
1
649
63
44
709
540










Molecular Recognition Features






MoRF SequenceStartStop




NANANA