<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08149

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSASGTAAVSGGSLPALLMANGGGGGSGGPGGGPGGGKGIGKLDIKPPGGGGPSAGGTGTAGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFQEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSLQHYADVHAQLHKAPLGVVQKRRGGHPMRLTYFVAPYELLDLTTRTMNVLSAELIAQERIGCSVAVVLEASSANKLQIQPLLVVNAGSGSAASVLQPVYTPIEKHNSTSLPATFVLRLSKPMPLNSAMMRAIRGIVGGSGAGEQQLAGEGSSGGGGGGLPGSLLGLIAHHASAGSVTDLAKGLLVSLPDQYHCYFLTDNPSLRGMMVSSIPFTEPQHVPKILTYLRQQAVFNQLLSSCIRTNAPGGGGGRPSALQQLLDGGSVHTIENGTTGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANIAVRIYCSEGETSDEHTVERISAVLQRCMSIPVTLRALMKAWEEEHEQKFKPNVLGSSTVSSGGAGGGPGGGGGGGGAGGAAPGLNNGGDGTGPAGGGLTGTGDDGTMNGFNLSSLGGPGPAVDGSGAGGGGGSAATNGTAAAQQQRGLMNGEGNGLTVSGGSLGLDFCDMLTERNGSGLGAAAAIGIVGGRAPGGMGAREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVGGGGGGGASDAVGTEKANTGAAGAAGATGATSSSSSTTTTTITSQDVGAAASGATGAGNSSEQRLQTGGATEEDTGGLPLFGETVPAAAGTDAKGSSLGGTTTTNAMISAKNEPPSVLPMGGGDGDTATGATMPLQSSSSSSLSSLSSAGFSLAGGPLAGEPAPDRPCPGTLLLESLDFSALEPDAAKRSTGGGQPTKRRRSSSSSSSSSSSSSSSSSSSSSTSAASDELEESVDLVEAEMSSFFAETNNTQPVAAIAKASFGSPSGKPALGAVSPIASKVVSPSGGAGLEKTPLPTISGSGLEIIPLATSAGTAAASGFPSPTVTSAPIAVPQSNATGSTSSTTATSSSTVKKSSSSSGGGSGSHRKTSDSSERTSSSKSEKKKKRKTDDSAMGPPNKLPYKSSGESSPHRSGGGVGGSSLSTSKSSPKHSSPVHHSSPKHSGSGGPLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDVGGGGGGTSGASISTTGSSSKERDKERSEKKALQFGTANTATGSSSLTATSAAGSSSSSSSGGRSKNSSLKLKQLDLAAGSSMSISMAAGIGDAGSSSPVAPMIDLTGPVPGAAAALGALGLPGSGMTTASSMLQALQAAKNRKTPTAAGGSTGLGGSLSAVIDKLKSAQSADDEAVLILPEMTITQQTTSASLAAGTGGIGSGVNIGGFGGLKDSAKSGSGLLPTGGTSSLANCVSSTAGIAGAALTQSSSVTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSNKSSSSSSNSGSGSKSSNKSGLKSGVSSGPVSSKQQQQQQQQQSNHTTSFSGAFPSSTKSPHYTSSTSGSSKAPFQKSNSFGSLGGSGGTGMKASKVSSPKSTSNPASSSSSSAYSSKEKGGSTSGRSKSSSASSLTGAMLTGAAGGTGSGTGSSSSALVNPISIMKMLGYPTGSMGNMEGFAKTLDTKFQIPKLSARSNSSATGTTSTGASESGEAGSKSAKDPAARKQKQQTPVTTAAPSVGSSPVRQFSSTSPSGEASARLLSDLLGAAAKSSNKMAPGTGAAPVDGTAGAGGGGGTGLHPLLPNIVQKMFGSDGSLQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGGSGSAPGTPTTTSSMVLPPFPSPISGGASNDGDSGTLMRPPSRPSSTISNHSHSSQDGIGGGSGNSGDAVAGSSPAVASMASMMMMNAMSAAAGGGQSPASTGGSLPLDSTSTQQLIAALAAKSGVLPPPPPNNLLNNHHSNHLNNHVVGGAAALNNLPSPASVSVHLVKSPAPSPLPFASPHSNASSTHAAGAAGLDDDLMDEALIGIGSK
Length2153
PositionMiddle
OrganismAnopheles merus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.266
Instability index53.64
Isoelectric point9.08
Molecular weight211461.85
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08149
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     375.59|      52|      52|    1155|    1206|       1
---------------------------------------------------------------------------
  916-  960 (52.98/ 8.84)	M..GGGDGDTATG.ATMPLQSSSSSSL......SSLSSAGFSL.A..GGP.......L.....AGEPAP
  987- 1030 (49.31/ 7.50)	T..GGGQPTKRRR.SSSSSSSSSSSSS......SSSSSSSSTS.A..AS..D..EL.........EESV
 1155- 1206 (75.12/16.86)	S..GGGSGSHRKT.SDSSERTSSSKSE......KKKKRKTDDS.A..MGPPN..KLPYKS...SGESSP
 1241- 1289 (55.76/ 9.84)	S..GGPLGFH....S...PKHGSSVSP......KHPLHSGGSStG..GGKPS..MSALKSaaaSG.SSP
 1671- 1721 (49.53/ 7.59)	G..SGGTGMKASK.VSSPKSTSNPASS......SSSSAYSSKE.K..GGSTS..G.RSKS...SSASSL
 1939- 1997 (47.34/ 6.79)	S..GGGSGSAPGT.PT...TTSSMVLPpfpspiSGGASNDGDS.GtlMRPPSrpSSTISN...HSHSSQ
 1998- 2048 (45.54/ 6.14)	DgiGGGSGNSGDAvAGSSPAVASMASM......MMMNAMSAAA.G..GGQSP..A....S...TGGSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     576.37|      95|     159|     636|     730|       2
---------------------------------------------------------------------------
    1-   68 (73.93/12.95)	.MSASGTA.AVSGGSLP.........allmangGGGGS............GGPGGGPG.........................GGKGIGKlDIKP....................PGGG......................................................................GPSAGGT...GTAGKvllGG................................
  636-  713 (123.88/28.17)	.................................GGGGG............GGAGGAAP.........................GLNNGGD.GTGP....................AGGGLTG..........TGDDGTMNGFNLSSLG.......................................GPGPAVDGS...GAGGG...GGSAATNGTAAA.................QQQRG
  714-  816 (107.21/23.09)	LMNGEGNGLTVSGGSLGldfcdmlterngsglgAAAAI............GIVGGRAP.........................GGMGARE.PPEP....................LAG...G..........AAKKRRMEDFCKS.............................................PKSDSNlsvGGGGG...GGASDAVGTEKA...................NTG
  817-  909 (80.16/14.85)	..........AAGAAGA................TGATS............SSSSTTTT.........................TI..TSQ.DVGA....................AASGATGagnsseqrlqTGGATEEDTGGLPLFG.......................................ETVPAAAGT...DAKGS.slGGTTTTNAMISA.................KNE..
 1320- 1486 (62.02/ 9.32)	KERSEKKALQFGTANTA................TGSSSltatsaagssssSSSGGRSKnsslklkqldlaagssmsismaagiGDAGSSS.PVAPmidltgpvpgaaaalgalglPGSGMTT.assmlqalqAAKNRKTPT..................................................AAGGS...TGLGG...SLSAVIDKLKSAqsaddeavlilpemtitQQTTS
 1487- 1540 (65.61/10.41)	ASLAAGT..........................GGIGS............GVNIGGFG.........................GL....K.DSAK....................SGSGLLP..........TGG.....T...SSLA.......................................NCVSSTAGI...AGA.......................................
 1783- 1885 (63.56/ 9.79)	RSNSSATGTTSTGAS.....................ES............GEAGS..............................KSAKD.PAAR.....................................KQKQQTPVTTAAPSVGsspvrqfsstspsgeasarllsdllgaaakssnkmapgtGAAP.VDGT...AGAGG...GGGT..............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.79|      19|      21|    2088|    2108|       7
---------------------------------------------------------------------------
 2089- 2108 (29.52/22.08)	VVGGAAAlNNLP..SPAS..VSVH
 2109- 2131 (27.27/ 9.22)	LVKSPAP.SPLPfaSPHSnaSSTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.24|      21|      21|     483|     503|       8
---------------------------------------------------------------------------
  483-  503 (38.32/22.57)	AVFNQLL.SSCIRTNAPGGGGG
  506-  527 (31.92/17.13)	SALQQLLdGGSVHTIENGTTGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.54|      12|      16|     321|     334|      10
---------------------------------------------------------------------------
  321-  334 (16.14/17.16)	VLEA...SSANKLQiqP
  337-  351 (15.40/ 7.38)	VVNAgsgSAASVLQ..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.73|      17|      17|    1115|    1131|      11
---------------------------------------------------------------------------
 1115- 1131 (30.30/15.61)	GFPSPTVTSAPIAVPQS
 1135- 1151 (26.43/12.37)	GSTSSTTATSSSTVKKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.03|      17|      20|    1898|    1914|      12
---------------------------------------------------------------------------
 1736- 1752 (22.29/ 8.25)	GTGSSS....SALVNPISIMK
 1898- 1914 (28.84/13.99)	MFGSDG....SLQTKSNSSDG
 1916- 1936 (25.90/11.41)	MFPTAGraspGMLSGSASRDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.50|      19|      20|     424|     442|      13
---------------------------------------------------------------------------
  424-  442 (31.19/20.14)	HASAGSVTDLA..KGLLVS.LP
  444-  465 (29.31/18.41)	QYHCYFLTDNPslRGMMVSsIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.79|      17|      27|     220|     236|      23
---------------------------------------------------------------------------
  220-  236 (26.42/19.57)	LASIYQLNAEKKIKVNA
  247-  263 (29.38/22.63)	LHTLYTLSLQHYADVHA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.64|      22|      27|     560|     581|      24
---------------------------------------------------------------------------
  560-  581 (37.29/30.96)	LQNIANIAVRIYCSEGETSDEH
  590-  611 (39.34/33.15)	LQRCMSIPVTLRALMKAWEEEH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.33|      15|      85|    1210|    1224|      27
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 1210- 1224 (29.10/10.25)	GGGVGGSSLSTSKSS
 1300- 1314 (28.23/ 9.67)	GGGTSGASISTTGSS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08149 with Med1 domain of Kingdom Metazoa
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