<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08132

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMLSVLSLVYIACINISLSFLQIVELKEKKTCPNEMTYTFYLVLVKPSSVEEGQSPDVLSGQPPQPSAAGGPAPGSDAANAAMPKMYLRVLSMIEFDTFVATHGPGTYIDDPSPTSTSGTSVKRKVSPLDNALSAIGPPLKQQKTIYPAYFIPELAHVVAMCDEKLPFVTLAKEFSMRKIPHGGLQVEANATSLVLKLLTLPQPKPPQAPPTPQQQQQQQQQQQPGTSDAKSSGAGGSANEPKTVHVPPIDKQVWNALLKRLLSVSVRAQVNKSNQTRLWTMELVFYGSPLPSLHHKEQGMRRAVYLQYEMQPVESVSKVVDQLLSDWSKIVYLYTLVHEFREQYNNEKYNLPSMVAIKSYSYTNLLLAYGPNKDVSVNICWDTEAKEFRLVFTGGNSAINAHSMMRDQLQAHLNHNYSMAQVVHMLHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRFRGGGLCTIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVFRRRSQSEDDNPPSPVTLEDPSAGAGNNGGGGGGGGGAGGGANTFLSGGTGMRGPQSPRDPGLRFAAPLTPPTSSNPHTPASPHPIGGGGGAGGAGGAGGQGGQGGQQQGHMNNFNMTSPPASHMPHPSPGGGLMPSSPLNAQPSPMAAHSPGPSSLSYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYTSRVLPARSWAGAIPTTLTYEALDTLCRATPHPQKEVPGPELSPLERFLGSVFMRRQLQRIIHQEESLMAITSNEPGVVVFKADCLQYQVFLNPNHMQSLHLKVDQLPMGPMMDGKPPYQWAAQDLQILEQFFDHRVAAPPYRPAVMTSFTRMLNLPAKVLKDFIQIMRLDLMPELVQGNKWNVQFVLRVPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMEWKDAVTMLLPMVYDMNMNHTTLAERREPMPPQLTSAVSAHLRRFSECSVLLPDECSLFPAVHDLLLTLSLPNEPPAPGQMQMQQLGGVMQPGGGPGVPGGPGGPMGGQIGGPTPQVVPQVGSSPSPMMHSPMQQMGGGGPQPGAYGGMVGGPGGGPQSGGPVGGGPGGPN
Length1130
PositionTail
OrganismAnopheles melas
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy-0.289
Instability index60.75
Isoelectric point8.53
Molecular weight121482.69
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08132
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     339.49|      49|      50|     560|     609|       1
---------------------------------------------------------------------------
  529-  578 (62.53/18.44)	RRSQS.....EDDN.....PPS.PVTLEDPSAGA......GNngggggGGGGA.GGGANTfLS..GGTGM
  579-  626 (78.76/22.12)	RGPQS....PRDPGLRFAAPLT.PPTSSNPHTPA......SP...hpiGGGGG.AGGA.......GGAGG
  627-  669 (56.89/13.95)	QGGQG....GQQQGHMNNFNMTsPPASHMPH.PS...................pGGGLMP.SS..PLNAQ
  670-  711 (68.83/18.41)	PSPMA....AHSPGPSSLSYMQ.SHTDGSPFAAL......SP......AASN.........WP..GSPGM
 1072- 1128 (72.48/19.77)	PTPQVvpqvGSSPSPMMHSPMQ.QMGGGGPQPGAyggmvgGP......GGGPQ.SGG.....PvgGGPGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.66|      13|      41|     202|     214|       2
---------------------------------------------------------------------------
  202-  214 (27.07/12.83)	QPKPPQAPPTPQQ
  240-  252 (24.59/10.85)	EPKTVHVPPIDKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.01|      12|      22|    1031|    1047|       6
---------------------------------------------------------------------------
 1031- 1047 (20.44/17.72)	PNEPPAPGqmqmqQLGG
 1055- 1071 (20.57/ 6.22)	PGVPGGPGgpmggQIGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08132 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FRRRSQSEDDNPPSPVTLEDPSAGAGNNGGGGGGGGGAGGGANTFLSGGTGMRGPQSPRDPGLRFAAPLTPPTSSNPHTPASPHPIGGGGGAGGAGGAGGQGGQGGQQQGHMNNFNMTSPPASHMPHPSPGGGLMPSSPLNAQPSPMAAHSPGPSSLSYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYTS
2) LLTLPQPKPPQAPPTPQQQQQQQQQQQPGTSDAKSSGAGGSANEPKTVH
3) LSLPNEPPAPGQMQMQQLGGVMQPGGGPGVPGGPGGPMGGQIGGPTPQVVPQVGSSPSPMMHSPMQQMGGGGPQPGAYGGMVGGPGGGPQSGGPVGGGPGGPN
527
197
1028
734
245
1130










Molecular Recognition Features






MoRF SequenceStartStop




NANANA