<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08129

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFHKARNKDEYLGFVARLILHVREMNTKHKNQQNAAAAAAAAAQQAQQEGGGNSSQQGGGGGGGGSGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGAGQASNLLHSLRPQMQMGGMGGPMQGNRVGMGPGNQMGGMMGGPNQMQGPGAGMVGGMPSQMGVGMGPGGMSGGKIVGMGGQQQQMAQLNAMQVNQMQQAQQQQQQQQAGMSQPQQQQQQQQQQQQQGGIAQGQGGPVPQMGVGPGGPNQMNPMVMGQIQAQLQNQNAMGGQQMGTVGGTMNAGNQMGQMVGANAGMNPQAMGMASNQVVRQQQLQQQGMGQQAMQQQQQAGGMGPGAVPNQMNPGVAMGPGGVVGPAGGGGVMGPGPNQMLGAGGAGGPGAGQQGNFVGMGANAMVRKPPEMMPGGNVYPGSGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMGGVAQRSTIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYRALTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILSNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAVSSSLQAATGNHTLQRTFRPCLEALFGPDIKNLPPPAKQSRLALDDTGAAGGTGGGVTTGGATTTTTNTTTAAATTGSASSATSTTASSTTAPQEIPHILQGEIARLDQKFKVSLDQCAISGTRTIKLICWLDDKNLPCVPPVAVTIPEDYPSTAPSCSLIEQEYNATPFLILVQKSLMARICKLPGLFTLSHLLDTWEMSVRQACSPNPTIVAPTGTSVLLGM
Length852
PositionTail
OrganismAnopheles melas
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.02
Grand average of hydropathy-0.441
Instability index51.50
Isoelectric point9.18
Molecular weight87653.57
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08129
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     184.26|      32|      32|     118|     149|       2
---------------------------------------------------------------------------
  118-  149 (71.83/21.69)	NLASQGTRPQMMGQM......GVGPGGPMGGQ...MGGAGQ
  152-  173 (35.78/ 6.07)	NLL.HSLRPQM..QM......G.GMGGPMQGN.........
  193-  230 (38.73/ 7.35)	.M..QGPGAGMVGGMpsqmgvGMGPGGMSGGKivgMGGQQQ
  360-  382 (37.92/ 7.00)	QLQQQGMGQQAMQQ...............QQQ...AGGMGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.78|      19|      23|     476|     497|       5
---------------------------------------------------------------------------
  487-  510 (26.50/ 6.79)	GahGPPSHPGQmiPSPAlIPSP.NP
  526-  545 (35.28/ 9.21)	G..GSLNTPGQ..PGGA.VPSPlNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.83|      28|      43|     286|     313|       6
---------------------------------------------------------------------------
  274-  291 (33.83/ 7.05)	GGI...AQ......GQ..GG..PVP..................QMGVGP
  292-  337 (42.84/11.18)	GGP...NQMNPMVMGQIQAQLQNQNamggqqmgtvggtmnagnQMGQMV
  424-  451 (38.16/ 9.03)	GGPgagQQGNFVGMG.ANAMVRKPP..................EM..MP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.73|      14|      84|      91|     104|       7
---------------------------------------------------------------------------
   91-  104 (29.47/ 9.49)	GGGNSSQQGGGGGG
  176-  189 (31.26/10.62)	GMGPGNQMGGMMGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.11|      13|      15|     686|     698|       8
---------------------------------------------------------------------------
  686-  698 (24.29/13.96)	TTGGA...TTTTTNTT
  703-  718 (17.82/ 8.26)	TTGSAssaTSTTASST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.58|      14|      16|     622|     635|      10
---------------------------------------------------------------------------
  622-  635 (21.96/14.24)	NNPLVEAVSSSLQA
  639-  652 (25.62/17.80)	NHTLQRTFRPCLEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.11|      16|      17|     562|     577|      13
---------------------------------------------------------------------------
  562-  577 (26.96/21.11)	IEPLKRMIAKMENDDI
  580-  595 (25.15/19.16)	IAKMKRLLEILSNPSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08129 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFH
2) PPAKQSRLALDDTGAAGGTGGGVTTGGATTTTTNTTTAAATTGSASSATSTTASSTTAPQE
3) VREMNTKHKNQQNAAAAAAAAAQQAQQEGGGNSSQQGGGGGGGGSGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGAGQASNLLHSLRPQMQMGGMGGPMQGNRVGMGPGNQMGGMMGGPNQMQGPGAGMVGGMPSQMGVGMGPGGMSGGKIVGMGGQQQQMAQLNAMQVNQMQQAQQQQQQQQAGMSQPQQQQQQQQQQQQQGGIAQGQGGPVPQMGVGPGGPNQMNPMVMGQIQAQLQNQNAMGGQQMGTVGGTMNAGNQMGQMVGANAGMNPQAMGMASNQVVRQQQLQQQGMGQQAMQQQQQAGGMGPGAVPNQMNPGVAMGPGGVVGPAGGGGVMGPGPNQMLGAGGAGGPGAGQQGNFVGMGANAMVRKPPEMMPGGNVYPGSGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMGGVAQRSTIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREK
1
663
63
44
723
554










Molecular Recognition Features






MoRF SequenceStartStop




NANANA