<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08128

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSASGTAAVSGGSLPALLMANGGGGGGPGGGPGGGKGIGKPDMKPPGGGGPSAGGTGTAGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFQEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSLQHYADVHAQLHKAPLGVVQKRRGGHPMRLTYFVAPYELLDLTTRTMNVLSAELIAQKRIGCSVAVVLEASSANKLQIQPLLVVNAGSGSAASVLQPVYTPIEKHNSTSLPATFVLRLSKPMPLNSAMMRAIRGIVSGSGAGEQLQAGEGSSGGGGGLPGSLLGLIAHHASAGSVTDLAKGLLVSLPDQYHCYFLTDNPSMRGMMVSSIPFTEPQHVPKILTYLRQQAVFNQLLSSCIRTNAPGGGGGRPSALQQLLDGGSVHTIENGTTGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANIAVRIYCSEGETSDEHTVERISAVLQRCMSIPVTLRALMKAWEEEHEQKFKPNVLGSSTVSSGGAGGGPGGGGGGGGAGGAAPGLNNGGDGTGPAGGGLTGTGDDGTMNGFNLSSLGGPGPAVDGSGAGGGGGSAATNGTAAAQQQRGLMNGEGNGLTVSGGGGGSLGLDFCDMLTERNGSGLGAAAAIGIVGARAPGGMVAREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVGGGGGGGACDAVGTEMANIGAVVAAGANGATTSSSSSSSSNSTTTTTITSQDVGAAASGATGAGNSSEQRLQTGGATEEDTGGLPLFGETVPAAAGTDAKGSSLGGTTTTNAMIAAKNEPPSVLPMGGGDGDTATGATMPLPSSSSSSLSSLSSAGFSLAGGPLAGEPAPDRPCPGTLLLESLDFSALEQDGAKRSTGAGQPTKRRRSSSSSSSSSSSSSSSSSSSSSTSAASDELEESVDLVEAEMSSFFAETNNTQPVAAIAKASFGSPSGKPALGAVSPIASKVVSPSGGAGLEKTPLPTISGSGLEIIPLATSAGTVTASGFPSPSVTSAPIAVPQSNATGGTSSTISTSSSTVKKSSSSSGGGSGSHRKTSDSSERTSSSKSEKKKKRKTDDSAMGPPNKLPYKSTGESSPHRSGGGVGGSSLSTSKSSPKHSSPVHHSSPKHSGSGGPLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDVGGGGGGGGTGGASISTTGSSSKERDKERSEKKALQFGTANTATGSSSLTATSAAGSSSSSSSGGRSKNSSLKLKQLDPAAGSSMSISMAAGIGDAGSSSPVAPMIDLTGPVPGAAAALGGLGLPGPGMTTASSMLQALQAAKNRKTPTAAGGSTGLGGSLSAVIDKLKSAQSADDEAVLILPEMTITQQTTSASLAAGTGGIASGVNIGGFGGLKDSAKSGSGLLPTGGTSSLANCVSSTAGIAGAALTQSSSVTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSNKSSSSSSNSGSGSSKSSNKSGLKSGVSSGPVSSKQQQQQQQQQQQQSNHTTSFSGAFPSSTKSPHYTSSTSGSSKTPFQKSNSFGSLGGSGGTGMKASKVSSPKSTSNPASSSSSSAYSSKEKGGSTSGRSKSSSASSLTGAMLAGATGGTGSGTGSSSSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNSSATGTASTGTSESGEAGSKSAKDPAARKQKQQTPVTTAAPSVGSSPVRQFSSTSPSGEASARLLSDLLGAAAKSSNKMAPGTGAAPVDGTAGAGGGGGAGLHPLLPNIVQKMFGSDGSLQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGGSGSAPGTPTTTSSMVLPPFPSPISGGASNDGDVGSGTLMRPPSRPSSTISNHSHSSQDGIGGGSGNSGDAVAGSTPAVASMASMMMMNAMSAAAGGGQSPASTGGSLPLDSTSTQQLIAALAAKSGVLPPPPPNNLLNNHHSNHLNNHVVGGAAALNNLPSPAAVSVHLVKSPAPSPLPFASPHSNASSTHAAGAAGLDDDLMDEALIGIGSK
Length2167
PositionMiddle
OrganismAnopheles melas
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.264
Instability index54.21
Isoelectric point9.09
Molecular weight212944.67
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08128
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    2178.76|     580|     602|     801|    1402|       1
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  372-  718 (345.73/49.57)	KPMP....LNSAMMRAIR..GIVSGSGAGEQLQAGEGSSGGGGGLPGSllgliAHHASAGSVTDLAKGLL...VSLPD.QYHCYFLTDNPSMRGMMVSSIPFTEPQHVPKIltylrqQAVfNQLLSSCIrtnAP...GGGGGrpsalqqlLDGGSVHTIengTTGGLLVFEVsALSCQN.ITVS.LIHPYEESlATVEFDLQN......IANIAVRIYC..............SEGE.TSDEH..TV...ERIS.........AvlqrcmsipvtlralmKAWEEEHEQKFK......PNVL.........G.SSTVSSGGA.GG....................G......PGGGGGGGGAGGAAPG..........LNNGGDGTG...PA...GGGLTGTGDDGtmngfnlS...SLGGPGPAVDGSGAGGGGGSAATNGT.........AAAQQQRGLMNGEGNG..............................................................................................................................................................................................................................................................................................
  723-  967 (223.81/33.67)	...............................................................................................................................................................................................................................................................................................................................................................................................................................................GGGGGSLG.............................LDFCDMLTE.....RNGSGLGAAAAIGIVGARAPGGmvaREPPEPLaggaaKKRRMEDFCKSPKSDS.NLSVGG.G..........G.......GGGACDAVGTEMANIGAVVAAGANGATTSSSSSSSSNSTTTTTITSQDVGAAASGATGAGNS.SE..QRLQTG.GATEEDTGGLP...LFGETVPA..AAGTD..AKGSSL.....GGTTTTNAmiAAKNEPPSVLPMGGGDG......DTA..TGATMPLP.SSSSSSLSSLSSAGfsLAggplAGEPAPD
  968- 1574 (886.00/152.49)	RPCPGTllLESLDFSALEqDGAKRSTGAGQPTKRRRSSSSSSSSSSSS.....SSSSSSSSSTSAASDELEESVDLVEAEMSSFFAETNNTQPVAAIAKASFGSPSGKPAL......GAV.SPIASKVV...SP...SGGAG........LEKTPLPTI...SGSGLEIIPL.ATSAGT.VTASGFPSPSVTS.APIAVPQSNA.....TGGTSSTISTSSS....TVKKSSSSSGG.GSGSHRKTSDSSERTS.........S................SKSEKKKKRKTDDSAMGPPNKLPYKS....TGESSPHRSGGGVGGsslstSKSS.......PKHSSPVHHSSPKHSGSGGPLGFHSPKhgSSVSPkhpLHSGGSSTGgGKPS...MSALKSAAASG.......S...SPGSKSSDVGGGGGGGGTGGASISTT.........GSSSKERDKERSEKKALQFGTANTA.....TGSSSLTATSAAGSSSSSSSGG...RSKNSSL.....KLKQLDPAAGSSMSISMAAGIGDAGS.......SSP.......VAPMIDLTGPVP...GAAAALGGLGLPGPGMTTASSMLQALQAAKNRKTPTAAGGSTGLGGSlSAviDKLKSAqSADDEAVLILPemtITQQTTSAslAAGTGgiASGVNI.....GGFGGLKD..SAKS.GSGLLPTGGTSSlancvsSTAgiAGAAL.TQ.SSSVTSAPSLTAA...LT....SGKASEY
 1575- 2148 (723.21/114.49)	MVKPSS.............DGIKLTI......QNKKGSNKSSSSSSNS.....GSGSSKSSNKS.G...LKSGVS..SGPVSS....KQQQQQQQQQQQQSNHTTSFS.........GAF..PSSTK.....SPhytSSTSG........SSKTPFQKS...NSFG....SL.GGSGGTgMKASKVSSPKSTS.NPASSSSSSAysskeKGGSTSGRSKSSSasslTGAMLAGATGGtGSGTGSSSSALVNPISimkmlgyptG................SMGNMEGFAKSLDTKFQIP.KLSARSnssaTGTASTGTSESGEAG.....SKSAkdpaarkQKQQTPVTTAAPS.VGSSPVRQF......SSTSP.........S...GEASarlLSDLLGAAAKS.......SnkmAPGTGAAPVDGTAGAGGGGGAGLHPLlpnivqkmfGSDGSLQTKSNSSDGSM.FPTAGRAspgmlSGSAS.RDGFRSGGGSGSAPGT...PTTTSSM.....VL....PPFPSPIS.GGASNDGDVGSgtlmrppSRPsstisnhSHSSQDGIGGGSGNSGDAV.AGSTPAVASMASMMMMNAMSAAAGGGQS.PASTGGSLPLDST.ST..QQLIAA.LAAK..SGVLP......PPPPN..NLLNN..HHSNHLnnhvvGG.....A..AALNNLPS..PAAVSVH......LVK..SPAPSPLPfASPHSNASSTHAAG...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.18|      18|      22|      19|      36|       2
---------------------------------------------------------------------------
   19-   36 (39.39/12.68)	MANGGGGGGPGGGPG.GGK
   43-   61 (33.80/ 9.61)	MKPPGGGGPSAGGTGtAGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.05|      16|      16|     109|     124|       4
---------------------------------------------------------------------------
  109-  124 (24.96/18.02)	YALDAVEKSNLQKTLD
  128-  143 (27.09/20.24)	YCIKVTTRQGLVERLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.03|      19|      20|     330|     348|       5
---------------------------------------------------------------------------
  330-  348 (30.64/14.96)	IQPLLVVNAGSGSAASVLQ
  351-  369 (32.39/16.26)	YTPIEKHNSTSLPATFVLR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08128 with Med1 domain of Kingdom Metazoa
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