<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08128

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSASGTAAVSGGSLPALLMANGGGGGGPGGGPGGGKGIGKPDMKPPGGGGPSAGGTGTAGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFQEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSLQHYADVHAQLHKAPLGVVQKRRGGHPMRLTYFVAPYELLDLTTRTMNVLSAELIAQKRIGCSVAVVLEASSANKLQIQPLLVVNAGSGSAASVLQPVYTPIEKHNSTSLPATFVLRLSKPMPLNSAMMRAIRGIVSGSGAGEQLQAGEGSSGGGGGLPGSLLGLIAHHASAGSVTDLAKGLLVSLPDQYHCYFLTDNPSMRGMMVSSIPFTEPQHVPKILTYLRQQAVFNQLLSSCIRTNAPGGGGGRPSALQQLLDGGSVHTIENGTTGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANIAVRIYCSEGETSDEHTVERISAVLQRCMSIPVTLRALMKAWEEEHEQKFKPNVLGSSTVSSGGAGGGPGGGGGGGGAGGAAPGLNNGGDGTGPAGGGLTGTGDDGTMNGFNLSSLGGPGPAVDGSGAGGGGGSAATNGTAAAQQQRGLMNGEGNGLTVSGGGGGSLGLDFCDMLTERNGSGLGAAAAIGIVGARAPGGMVAREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVGGGGGGGACDAVGTEMANIGAVVAAGANGATTSSSSSSSSNSTTTTTITSQDVGAAASGATGAGNSSEQRLQTGGATEEDTGGLPLFGETVPAAAGTDAKGSSLGGTTTTNAMIAAKNEPPSVLPMGGGDGDTATGATMPLPSSSSSSLSSLSSAGFSLAGGPLAGEPAPDRPCPGTLLLESLDFSALEQDGAKRSTGAGQPTKRRRSSSSSSSSSSSSSSSSSSSSSTSAASDELEESVDLVEAEMSSFFAETNNTQPVAAIAKASFGSPSGKPALGAVSPIASKVVSPSGGAGLEKTPLPTISGSGLEIIPLATSAGTVTASGFPSPSVTSAPIAVPQSNATGGTSSTISTSSSTVKKSSSSSGGGSGSHRKTSDSSERTSSSKSEKKKKRKTDDSAMGPPNKLPYKSTGESSPHRSGGGVGGSSLSTSKSSPKHSSPVHHSSPKHSGSGGPLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDVGGGGGGGGTGGASISTTGSSSKERDKERSEKKALQFGTANTATGSSSLTATSAAGSSSSSSSGGRSKNSSLKLKQLDPAAGSSMSISMAAGIGDAGSSSPVAPMIDLTGPVPGAAAALGGLGLPGPGMTTASSMLQALQAAKNRKTPTAAGGSTGLGGSLSAVIDKLKSAQSADDEAVLILPEMTITQQTTSASLAAGTGGIASGVNIGGFGGLKDSAKSGSGLLPTGGTSSLANCVSSTAGIAGAALTQSSSVTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSNKSSSSSSNSGSGSSKSSNKSGLKSGVSSGPVSSKQQQQQQQQQQQQSNHTTSFSGAFPSSTKSPHYTSSTSGSSKTPFQKSNSFGSLGGSGGTGMKASKVSSPKSTSNPASSSSSSAYSSKEKGGSTSGRSKSSSASSLTGAMLAGATGGTGSGTGSSSSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNSSATGTASTGTSESGEAGSKSAKDPAARKQKQQTPVTTAAPSVGSSPVRQFSSTSPSGEASARLLSDLLGAAAKSSNKMAPGTGAAPVDGTAGAGGGGGAGLHPLLPNIVQKMFGSDGSLQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGGSGSAPGTPTTTSSMVLPPFPSPISGGASNDGDVGSGTLMRPPSRPSSTISNHSHSSQDGIGGGSGNSGDAVAGSTPAVASMASMMMMNAMSAAAGGGQSPASTGGSLPLDSTSTQQLIAALAAKSGVLPPPPPNNLLNNHHSNHLNNHVVGGAAALNNLPSPAAVSVHLVKSPAPSPLPFASPHSNASSTHAAGAAGLDDDLMDEALIGIGSK
Length2167
PositionMiddle
OrganismAnopheles melas
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.264
Instability index54.21
Isoelectric point9.09
Molecular weight212944.67
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08128
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    2178.76|     580|     602|     801|    1402|       1
---------------------------------------------------------------------------
  372-  718 (345.73/49.57)	KPMP....LNSAMMRAIR..GIVSGSGAGEQLQAGEGSSGGGGGLPGSllgliAHHASAGSVTDLAKGLL...VSLPD.QYHCYFLTDNPSMRGMMVSSIPFTEPQHVPKIltylrqQAVfNQLLSSCIrtnAP...GGGGGrpsalqqlLDGGSVHTIengTTGGLLVFEVsALSCQN.ITVS.LIHPYEESlATVEFDLQN......IANIAVRIYC..............SEGE.TSDEH..TV...ERIS.........AvlqrcmsipvtlralmKAWEEEHEQKFK......PNVL.........G.SSTVSSGGA.GG....................G......PGGGGGGGGAGGAAPG..........LNNGGDGTG...PA...GGGLTGTGDDGtmngfnlS...SLGGPGPAVDGSGAGGGGGSAATNGT.........AAAQQQRGLMNGEGNG..............................................................................................................................................................................................................................................................................................
  723-  967 (223.81/33.67)	...............................................................................................................................................................................................................................................................................................................................................................................................................................................GGGGGSLG.............................LDFCDMLTE.....RNGSGLGAAAAIGIVGARAPGGmvaREPPEPLaggaaKKRRMEDFCKSPKSDS.NLSVGG.G..........G.......GGGACDAVGTEMANIGAVVAAGANGATTSSSSSSSSNSTTTTTITSQDVGAAASGATGAGNS.SE..QRLQTG.GATEEDTGGLP...LFGETVPA..AAGTD..AKGSSL.....GGTTTTNAmiAAKNEPPSVLPMGGGDG......DTA..TGATMPLP.SSSSSSLSSLSSAGfsLAggplAGEPAPD
  968- 1574 (886.00/152.49)	RPCPGTllLESLDFSALEqDGAKRSTGAGQPTKRRRSSSSSSSSSSSS.....SSSSSSSSSTSAASDELEESVDLVEAEMSSFFAETNNTQPVAAIAKASFGSPSGKPAL......GAV.SPIASKVV...SP...SGGAG........LEKTPLPTI...SGSGLEIIPL.ATSAGT.VTASGFPSPSVTS.APIAVPQSNA.....TGGTSSTISTSSS....TVKKSSSSSGG.GSGSHRKTSDSSERTS.........S................SKSEKKKKRKTDDSAMGPPNKLPYKS....TGESSPHRSGGGVGGsslstSKSS.......PKHSSPVHHSSPKHSGSGGPLGFHSPKhgSSVSPkhpLHSGGSSTGgGKPS...MSALKSAAASG.......S...SPGSKSSDVGGGGGGGGTGGASISTT.........GSSSKERDKERSEKKALQFGTANTA.....TGSSSLTATSAAGSSSSSSSGG...RSKNSSL.....KLKQLDPAAGSSMSISMAAGIGDAGS.......SSP.......VAPMIDLTGPVP...GAAAALGGLGLPGPGMTTASSMLQALQAAKNRKTPTAAGGSTGLGGSlSAviDKLKSAqSADDEAVLILPemtITQQTTSAslAAGTGgiASGVNI.....GGFGGLKD..SAKS.GSGLLPTGGTSSlancvsSTAgiAGAAL.TQ.SSSVTSAPSLTAA...LT....SGKASEY
 1575- 2148 (723.21/114.49)	MVKPSS.............DGIKLTI......QNKKGSNKSSSSSSNS.....GSGSSKSSNKS.G...LKSGVS..SGPVSS....KQQQQQQQQQQQQSNHTTSFS.........GAF..PSSTK.....SPhytSSTSG........SSKTPFQKS...NSFG....SL.GGSGGTgMKASKVSSPKSTS.NPASSSSSSAysskeKGGSTSGRSKSSSasslTGAMLAGATGGtGSGTGSSSSALVNPISimkmlgyptG................SMGNMEGFAKSLDTKFQIP.KLSARSnssaTGTASTGTSESGEAG.....SKSAkdpaarkQKQQTPVTTAAPS.VGSSPVRQF......SSTSP.........S...GEASarlLSDLLGAAAKS.......SnkmAPGTGAAPVDGTAGAGGGGGAGLHPLlpnivqkmfGSDGSLQTKSNSSDGSM.FPTAGRAspgmlSGSAS.RDGFRSGGGSGSAPGT...PTTTSSM.....VL....PPFPSPIS.GGASNDGDVGSgtlmrppSRPsstisnhSHSSQDGIGGGSGNSGDAV.AGSTPAVASMASMMMMNAMSAAAGGGQS.PASTGGSLPLDST.ST..QQLIAA.LAAK..SGVLP......PPPPN..NLLNN..HHSNHLnnhvvGG.....A..AALNNLPS..PAAVSVH......LVK..SPAPSPLPfASPHSNASSTHAAG...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.18|      18|      22|      19|      36|       2
---------------------------------------------------------------------------
   19-   36 (39.39/12.68)	MANGGGGGGPGGGPG.GGK
   43-   61 (33.80/ 9.61)	MKPPGGGGPSAGGTGtAGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.05|      16|      16|     109|     124|       4
---------------------------------------------------------------------------
  109-  124 (24.96/18.02)	YALDAVEKSNLQKTLD
  128-  143 (27.09/20.24)	YCIKVTTRQGLVERLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.03|      19|      20|     330|     348|       5
---------------------------------------------------------------------------
  330-  348 (30.64/14.96)	IQPLLVVNAGSGSAASVLQ
  351-  369 (32.39/16.26)	YTPIEKHNSTSLPATFVLR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08128 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ARAPGGMVAREPPEPLAGGAAKKRRMEDFCKSPKSDSN
2) AVSVHLVKSPAPSPLPFASPHSNASSTHAAGAAGL
3) GSLPALLMANGGGGGGPGGGPGGGKGIGKPDMKPPGGGGPSAGGTGTAGKV
4) HEQKFKPNVLGSSTVSSGGAGGGPGGGGGGGGAGGAAPGLNNGGDGTGPAGGGLTGTGDDGTMNGFNLSSLGGPGPAVDGSGAGGGGGSAATNGTAAAQQQRGLMNGEGNGLTVS
5) IAALAAKSGVLPPPPPNNLLNNHHSNHLNNHVVGGAA
6) KPALGAVSPIASKVVSPSGGAGLEKTPLPTISGSGLEIIPLATSAGTVTASGFPSPSVTSAPIAVPQSNATGGTSSTISTSSSTVKKSSSSSGGGSGSHRKTSDSSERTSSSKSEKKKKRKTDDSAMGPPNKLPYKSTGESSPHRSGGGVGGSSLSTSKSSPKHSSPVHHSSPKHSGSGGPLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDVGGGGGGGGTGGASISTTGSSSKERDKERSEKKALQFGTANTATGSSSLTATSAAGSSSSSSSGGRSKNSSLKLKQLDPAA
7) KPSSDGIKLTIQNKKGSNKSSSSSSNSGSGSSKSSNKSGLKSGVSSGPVSSKQQQQQQQQQQQQSNHTTSFSGAFPSSTKSPHYTSSTSGSSKTPFQKSNSFGSLGGSGGTGMKASKVSSPKSTSNPASSSSSSAYSSKEKGGSTSGRSKSSSASSLTGAMLAGATGGTGSGTGSSSSAL
8) MGNMEGFAKSLDTKFQIPKLSARSNSSATGTASTGTSESGEAGSKSAKDPAARKQKQQTPVTTAAPSVGSSPVRQFSSTSPSGEASARLLSDLLGAAAKSSNKMAPGTGAAPVDGTAGAGGGGGAGLHPLLPNIVQKMFGSDGSLQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGGSGSAPGTPTTTSSMVLPPFPSPISGGASNDGDVGSGTLMRPPSRPSSTISNHSHSSQDGIGGGSGNSGDAVAGSTPAVASMASMMMMNAMSAAAGGGQSPASTGGSLPLDSTSTQQ
9) VAAGANGATTSSSSSSSSNSTTTTTITSQDVGAAASGATGAGNSSEQRLQTGGATEEDTGGLPLFGETVPAAAGTDAKGSSLGGTTTTNAMIAAKNEPPSVLPMGGGDGDTATGATMPLPSSSSSSLSSLSSAGFSLAGGPLAGEPAPDRPCPGTLLLESLDFSALEQDGAKRSTGAGQPTKRRRSSSSSSSSSSSSSSSSSSSSSTSAASDELEES
756
2118
12
608
2072
1070
1577
1773
819
793
2152
62
722
2108
1382
1756
2070
1035










Molecular Recognition Features






MoRF SequenceStartStop




1) GKGIGKPDMKPP
2) KKALQF
3) MSALKSAAA
4) RLLSDLLG
5) SLKLKQLD
35
1333
1282
1860
1372
46
1338
1290
1867
1379