<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08127

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMGNSSSSSSSNSSSNGSNSSSNSSNSLSALKASPRSSLSSSGIGSLKVRSESSLGAGGSCSLGSGGGGGVPMTPSIHSVFSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYETLQGEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAAEENRLVKKIRNLDLYANEHSRTMASGLGLAASGNSTNGGIGTNGMLMKGAAEASEALAEALSGGRPGTGGGSDNGAPNNGAGCTPLLGQIKMEIGCDGGQAGAAVGSANGGTPDRNGASAGNGGAGDGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGSIALDTLVDLQMSLSSGTGSGGGNGGGASSVPAIPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQQVMPPIPTSTVAGLVYKSTRQKQKEQAAAEREKQKQREQAEREREREQKQEQQQQQDQPDGQSESGGQGGAGGGTGRPLGVAGPTTTAGALGIGLGLLPIVKQEVGGLTVPQPLSTPNSLLGGLSGLNGGSLVHPYSNPPSQGAQSQPHSRPPSVNSLPGGIMGGGAGMLSPSPAGASGGGLFHPGGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGSPNPMGSLNFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQYPLDGVDSGGPGSNRGPMTPSSTGGSGPLGAGTVHPPLSSSGVGCGTGTPAGSRSIETNALLVNVLLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTAAGAEPTPSTTPGPAGGRSKASALAHLGLGGGGGSSSAFGAGMLGSPAVGRQEDKSAAVTINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKNGSLFEFLNGTAKAIKLEDADRGALATSAGGSSSAAGGDSLPLTLKVMDLLREQCSVVQSSSNSLHRAVNRYRGPLFGRGTENGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQQQQQQSSSGALVKGGTLRGQMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGTTAGSTGSSSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSSASASASLGGGAAGASSLGGGSMGQPGGNAMGQNRPDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPEWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2008
PositionMiddle
OrganismAnopheles melas
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.427
Instability index53.05
Isoelectric point5.88
Molecular weight211744.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08127
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     177.52|      21|      21|     333|     353|       1
---------------------------------------------------------------------------
  333-  353 (29.37/ 7.17)	PGSNKSSSGSGGFSEESKR..FP
  532-  551 (31.86/ 8.52)	PDGQSESGGQGGAGGGTGR...P
  626-  644 (27.93/ 6.38)	PSVN.SLPG.GIMGGGAGM..LS
  645-  665 (29.30/ 7.13)	P.SPAGASG.GGLFHPGGMggIP
  674-  694 (30.45/ 7.75)	PISPATPGGSMRVPTPQGS..CP
  765-  783 (28.61/ 6.75)	PMTPSSTGGSGPLGA..GT..VH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     133.11|      28|     111|     884|     914|       2
---------------------------------------------------------------------------
  241-  263 (27.95/ 6.94)	QIK.........M........EIGcD..G........GQAGAAVGSANGG
  399-  436 (34.37/10.39)	SIA...LDTLVDLqmslssgtGSG.GgnG........GGASSVPAIPNLG
  884-  912 (38.51/18.34)	..GrskASALAHL........GLG.G..G........GGSSSAFGAGMLG
 1364- 1396 (32.27/ 8.62)	......SSASASA........SLG.G..GaagasslgGGSMGQPGGNAMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.26|      24|     576|     507|     530|       3
---------------------------------------------------------------------------
  507-  530 (41.22/28.26)	QKQREQAEREREREQKQEQQQQQD
 1085- 1108 (41.04/28.10)	EQGRLQAINESKMDVDQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.84|      16|      22|      26|      44|       4
---------------------------------------------------------------------------
   29-   44 (26.44/ 7.28)	ALKASPRSSLSSSGIG
   53-   68 (29.40/ 6.57)	SLGAGGSCSLGSGGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     267.77|      61|     502|    1429|    1489|       5
---------------------------------------------------------------------------
 1429- 1489 (107.11/59.83)	PKFDHDSENRDQLNTSSA.SPADGMRIDDDGKDPPHIVLYIVEPFT.......CG..NDSPDVERLACLSL
 1849- 1911 (91.58/49.87)	PGSPSQFEGNQQSPGESG.SKGAGSRDGYGSQDSEEVGLVLQQPLA.......IGylVSTAPTGRMPEWFW
 1934- 1992 (69.08/35.45)	PTILQNTDDPLQQNQSSTeHPLDS.NI...TAD...VLRYVLE...gynllswLA..MDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     167.44|      52|     502|     696|     759|       6
---------------------------------------------------------------------------
  569-  603 (48.59/13.89)	GLLPI...VKQEV....................................................................GGL.........................TVPQPL...STPNSlLGGLSGLNGG
  604-  719 (50.20/14.61)	SLVHPysnPPSQGAQSQP..........HSRPpsvnslpggimgggagmlspspagasggglfhpggmggipVPLrQGM.......spispatpggsmrvptpqgscplPYPSPLGGAGSPNP.MGSLNFRRTT
  720-  808 (68.65/37.55)	PLLPP...PPYDVAIASPansvatpssyHSKQ........................................YPL.DGVdsGGPgsnrgpmtpsstggsgplgagtvhpPLSSSGVGCGTGTP.AGSRSIETNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.71|      13|      22|     294|     306|       7
---------------------------------------------------------------------------
  294-  306 (23.61/11.90)	DKGSIFLTDQDLQ
  317-  329 (27.10/14.77)	DDGGPFNDDPDLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     209.75|      65|     504|    1172|    1244|       8
---------------------------------------------------------------------------
 1172- 1244 (103.55/76.66)	TIQgPltWRQFHRLAGR.GTGQCEPQpipSLIVGyeKDWLSLAPYALHYWDKL..LLEPYSYPR..DVAYVAIVPDND
 1680- 1749 (106.20/56.64)	TVQ.P..WRLVVGRIGRiGHGELKGW...SWLLS..KPNLQRASKHLKDICEQcsLMHPIAVPSilSACLVTLEPDSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.28|      23|     499|    1027|    1067|      10
---------------------------------------------------------------------------
  206-  228 (41.44/12.47)	SEALAEALSGGR.PGTGGGSDNGA
 1044- 1067 (38.85/15.28)	SNSLHRAVNRYRgPLFGRGTENGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.37|      46|     696|     130|     185|      19
---------------------------------------------------------------------------
  130-  185 (66.69/66.80)	LLYDyTCVDAWMNHPVKRMRLAAeENRLVKKIRNLdlyanehsRTMASGLGLAASG
  814-  859 (85.68/54.71)	LLYD.TALNIFRDHNFKSCTLCV.CNAGAKCVGNI........RGADSGLYLALPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08127 with Med13 domain of Kingdom Metazoa
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