<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08125

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSADLRIVKLFEEVVEDKNIVPNFDEEEQRKKTEEGYKKIGTLFGAMAPESKEAAIRNYLGYVASVNHQNRVHNYLQVMNRMVALNIIPAKLLCDQLMCSEKLVYKNPCFWIEAFRLIRKVIGGVDYKGVREIMKCCKEKALSFPASVSVNILPQLLELVELIEHIFNRNACLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSAMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDEELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMECSEKEAAQGGQGAAGGTGMNEHEGDQSHTQWIWLHLSSQLIYFVLFQFATFQNIVNTLHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKEPLPVPDNNNPNCTHQMAPTCIWIHLMKRAQTENYNINRPVPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMVGGGQPLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYVSEPKPPGNIVSGESEELNRALILTLARSMHITGTGNDPQSSAWCKDLLQNIMVNTPHAWPQHTLYCFPPVLNEFFMQHNIPKESKQLLKKTVDEEYRNWASMTNENDIIAHFGMTVNPPLFLCLVFKMIIETDGISPVAYKILERIGARALSTHLRKMCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIITIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTTEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPSLPVYFGNVCLRFLPVLDIIVHRYLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWALTEAYQAYMMTKESDNVNWVPELSYYINLVRRMQDTMDGKNIFAGTDWRFNEFPNPPAHALYVTCVELLGLPVGPSVVANSIIDVLVKGYPVVPNGVIHNWANTIGLIMAALPEAYWSVIYERMQEALSSKAMKEWTYRQSPFDMFNFKIVKEAMLDRSYVTVLAIVHSIFHHFGIGQLATITDSIKEKLKPLVHTEYQLIYLCHVVGPFLHRLSIERARAVADITLMLYELLEQVDKAQPAQPLRYMDPICDLLYHIKYMFVGDTMKTELEAIIRRLRPALQMRLRFITRLNVEEIGIDQNAAAAGGGAGGAATATGQGVAGAGPGVGPPPGGVAVGAPGATQGVVASGQAAPGTAAGPQQPQQVVGVVGNQNVALQQQLQQQQMGQGIQSHH
Length1449
PositionTail
OrganismAnopheles melas
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.097
Instability index45.43
Isoelectric point7.47
Molecular weight164335.53
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08125
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1195.95|     318|     327|     666|     992|       1
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  410-  732 (353.43/209.09)	...LYDILY..PE...KE.P......LPvPDNNNP.NCTHQMAPTCiwIHLMKRAQT...ENYNiNRpvpIALRLHFEYLQHLAMpSNNPTLFmgseyrfalLCNAYS..TQTDYFSR..PMQALIDTIL..GNSKNPQ............ANmVGGGQPLPtaplsmRVLDslTIHS.....KMS...LIHS...IVMHMIKQAQnkssipNGNNMAPALVETYSRLLVYTEIESlGIKGFLGQLLPQVFKSQAWgilytllemfsyrmHHIHSHYRVQLLTHLHSLAS......VPHTNqmqLH.......S.......CVE.....................STALRLIIG.LGSV.EVQAQLSRYVSEPKPPGNIVSGESEELNRALILTlarsmhITGTGNDPQSSAWC
  733- 1055 (518.11/306.62)	KDLLQNIMVNTPH...AW.PQHTLYcFP.PVLNEF.FMQHNIPKES..KQLLKKTVD...EEYR.NW...ASMTNENDIIAHFGM.TVNPPLF.........LCLVFKMIIETDGISP..VAYKILERIG..ARALSTHLRKMCdYLLFEVAN.SGGGAHVN......KCVD..TINDMiWKYNII...TIDR...LVLCLILRTL......DGNEAQVSFYIIQLLLLKTTEFRN.RVQEFITINSPEHWKQNNW..............HERHLAFHQKFPEKFAPDES......VSHPS...LPVY..FGNV.......CLRFL.PVLDIIVH.RYLEVPTQLSKTLDVILDhLGSLyKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGT......VVGSLKDVRPENWA
 1057- 1344 (324.41/180.42)	TEAYQAYMMTKESdnvNWvPELSYY......INLVrRMQDTM..DG..KNIFAGT.DwrfNEFP.NP...PAHALYVTCVELLGL.PVGPSVV.........ANSIIDVLVKGYPVVPngVIHNWANTIGliMAALPEAYWSVI.YERMQEAL.SSKAMKEW......TYRQ..SPFDM.FNFKIVkeaMLDRsyvTVLAIVHSIF......H......HFGIGQLATI.TDSIKE.KLKPLV......H....................TEYQLIYLCHVVGPFLHRLSieraraVADIT...LMLYelLEQVdkaqpaqPLRYMdPICDLLYHiKYMFVGDTMKTELEAIIR.RLRP.ALQMRL.RFI............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      58.21|      11|      15|    1356|    1366|       2
---------------------------------------------------------------------------
 1356- 1366 (20.43/ 9.23)	QNAAAAGGGAG
 1374- 1384 (20.92/ 9.61)	QGVAGAGPGVG
 1406- 1414 (16.86/ 6.49)	Q..AAPGTAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.06|      14|      44|     330|     344|       3
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  330-  344 (24.75/20.99)	NEHEGdQSHTQWIWL
  376-  389 (27.31/17.42)	NLRRG.RDHLMWVFL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.33|      30|      47|     166|     199|       8
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  166-  199 (43.53/45.55)	IFNRNAcLLPayfIINEIKKTDYQNMHWRVSNLT
  215-  244 (53.81/37.85)	IIGHSA.MLP...IVEHSSYADNLIIPWKLDPDT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08125 with Med23 domain of Kingdom Metazoa
Unable to open file!