<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08124

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMNSGRLGLAPLLQENPLWISWHDSNWIPVLNPGNVMDYFSEKSNPFYDRTCNNEIVRMQRQSLELLNNMTGVEYIPLHVQDPILYVIRKQHRHSPTEATPMADYYIIAGTVYQAPDLASVFNSRILSTVHHLQTAFDEASSYSRYHPSKGYSWDFSSNKASTHAMAEQVAEKTKTQTKKEAPVKEEPSSIFQRQRVDMLLGDLLRKFPLPLPQMTNNPTGGNPSDAGNASNNHGGAAGDSDHVGSDATLIKQEPTEGGTGRGGNSDVPPEKKMKL
Length275
PositionHead
OrganismAnopheles melas
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.08
Grand average of hydropathy-0.666
Instability index44.51
Isoelectric point6.20
Molecular weight30564.82
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08124
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.51|      30|      65|      10|      39|       1
---------------------------------------------------------------------------
   10-   39 (57.60/31.23)	PLLQENP.LWISWHDSNWIPV.LNPGNVMDYF
   55-   75 (24.10/ 9.77)	..........IVRMQRQSLEL.LNNMTGVEYI
   76-  105 (41.82/21.13)	PLHVQDPiLYVIRKQHRHSPTeATP..MADYY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     205.03|      64|      68|     120|     187|       2
---------------------------------------------------------------------------
  120-  187 (98.74/61.00)	VFN.SRILSTVHHLQTAFDEASSYSRYHPSKGYSWDfSSNKASTHAMAEQVAEKTKTQTkkeAPVKEEP
  190-  254 (106.30/55.67)	IFQrQRVDMLLGDLLRKFPLPLPQMTNNPTGGNPSD.AGNASNNHGGAAGDSDHVGSDA...TLIKQEP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08124 with Med6 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FPLPLPQMTNNPTGGNPSDAGNASNNHGGAAGDSDHVGSDATLIKQEPTEGGTGRGGNSDVPPEKKMKL
2) THAMAEQVAEKTKTQTKKEAPVKEEPSSIFQ
207
162
275
192










Molecular Recognition Features






MoRF SequenceStartStop




1) HVGSDATLIKQEPTEGGTGRGGNSDVPPEKKMKL
242
275