<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08122

Description Mediator of RNA polymerase II transcription subunit 12
SequenceTGLGKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFESTSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAIGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVELQLIGKSSMALVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKARPQQEPFHNAYPKIKQALYTPLQPTPSAHTYNPQFMLDIITNPRRGGKIESGWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGTGKRSGLNTPVHPGSTPKSMAGSGDLSHILGTSDLQQNSHLNQDNATSLSDFAQHVLRQICSQEWVLERCLQHAEELCQHGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELEQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSPDLSNWLDMVARAAIDVFRVNEFLLNSPDVKQEKVKPSTWLVAPLGQDEQKEGLLQSLYSQLSQFLQNRDQSLETIGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVLTCDSAGSSTDAKGNKIAIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPLPDKLKDDMKADTPSSD
Length989
PositionKinase
OrganismAnopheles melas
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy-0.208
Instability index44.14
Isoelectric point6.26
Molecular weight110377.96
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08122
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.51|      31|      38|     436|     471|       2
---------------------------------------------------------------------------
  436-  471 (50.16/46.34)	RLSC..HLLLRLFKTIecpqpGLYSV.STSPNPITVGNA
  475-  508 (42.35/25.93)	KLSCdrHLLAAAHKNI.....GVAPVlAVLKGILVVGDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.18|      43|      51|     812|     854|       3
---------------------------------------------------------------------------
  812-  854 (71.61/49.55)	LATLIHSTLVSD...SQTERDENKKLYTNLMKKLRKELGDKNGPSI
  863-  908 (66.57/45.54)	LAKQTCEVLTCDsagSSTDAKGNKIAIDSIEKKNGLRLGDKQRVSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.66|      18|      19|     324|     341|       5
---------------------------------------------------------------------------
  305-  319 (18.29/ 8.78)	...RQLNESASNRYSFVC
  324-  341 (30.11/19.48)	AVTRDIDNDCLNDIAAMC
  346-  363 (30.26/19.62)	ACCNSLSTEWLGVLIALC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08122 with Med12 domain of Kingdom Metazoa
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