<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08112

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPEMQHALNNDWSKLQHLISELRYWITQRRCEKTLQHLPAATQDRLPLIYPQNHPIARMGPHKVFIQLYRHANVILIVELKEKKSCPNEMTYTFYLVLVKPSSVEEGQSQDTASTAAGQANQTSGAGGGNETVTAAMPKMYLRVLSMIEFDTFVATHGPGTYIDDPSTTSSASSSSTITKRKISPLESAMSSMGPPLKQQKTIYPAYFIPELAHVVAMCDEKLPFVTLAKEFTMRKIPHGGLQVEANATSLVLKLLTLPQPKPPQAPTSAQQQQQQQSGAGGSDAKAAAAASSGNEPKPVHVPPIDKQVWNALLKRLLSVSVRAQVNKSNQTRLWTMELVFYGSPLPSLHHKEQGMRRAVYLQYEMQPVESVSKVVDQLLSDWSKIVYLYTLVHEFREQFNNEKYNLPGMVTIKSYSYTNLLLAYGPNKDVSVSICWDTDAKEFRLVFTGGNSAINAHSMMRDQLQAHLNHNYSLAQIVHMLHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRFRGVGLCTIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVFRRRSQSEDDNPPSPVTLDDPSGHGGGGSGTGGGNNGGAGGGGGGGGTGGGSNTFLSGGTGMRGPQSPRDPGLRFAAPLTPPTSSNPHTPASPHPIGGGGGGGAGPGGAGGGGAGGAGGQGGQQQGHMNNFNMTSPPASHMPHPSPSGGLMPSSPLNAQPSPMAAHSPGPSSLPYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYTSRVLPARSWAGATPTTLTYEALDTLCRATSHPQKEVPGPELSPLERFLGSLMAITSNEPGVVVFKADCLQYQVFLNPNHMQSLHLKVDQLPMGPMMDGKPPYQWAAQDLQILEQFFDQRVAAPPYRPAVMTSFTRMLNLPAKVLKDFIQIMRLDLMPELVQGNKWNVQFVLRVPPSATPIVPVGTTTILSHRQKILFFIQITRVPYMPNMEWKDAVTMLLPMVYDMNMNHTTLAERREPMPPQLNSAVSAHLRRFSECSVLLPDECSLFPAVHDLLLSLTLPNEPPGQMQMQMGGVMQPGGGPGGPGGPGGPMGGQIGGPSPQVVPQVGSSPSPMMHSPMQQMGGGGQQPGGYGGMVGGPGGGPQSGGPGGGGPN
Length1180
PositionTail
OrganismAnopheles maculatus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles> Anopheles maculatus group.
Aromaticity0.07
Grand average of hydropathy-0.334
Instability index58.08
Isoelectric point8.76
Molecular weight126657.10
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08112
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     434.88|      57|      59|     619|     675|       1
---------------------------------------------------------------------------
  256-  297 (40.12/ 6.75)	.LT.LPQPKPPQA.......PTSaqqqQ.............QQ.........QSGAGGSDAKAAAAASSGNEP............
  619-  659 (67.13/15.55)	.........................................GG...AGGGGGGGGTGGGSNTFLSGGTGMRGPQSPRDPGLRFAA
  660-  713 (93.28/24.07)	PLT.PPTSSNPHT.......PAS....P.........hpigGG...GGGGAGPGGAGGGG....AGGAGGQGGQ...QQGHMNNF
  714-  787 (73.50/17.62)	NMTsPPASHMPHPspsgglmPSS....PlnaqpspmaahspGP...SSLPYMQSHTDGSPFAALSPAAS....NWPGSPGMPRPS
 1087- 1136 (92.97/23.96)	PNE.PPGQMQMQM.......GGV....M.............QP...GGGPGGPGG.PGGP...MGGQIGGPSPQVVPQVG...SS
 1137- 1180 (67.88/15.79)	P...SPMMHSPMQ.......QMG....G.............GGqqpGGYGGMVGGPGGGPQ...SGGPGGGGPN...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.74|      33|     487|      99|     131|       2
---------------------------------------------------------------------------
   99-  131 (57.65/32.16)	VKPSSV..EEGQSQD.......TASTAAGQANQTSGAGGGNE
  577-  618 (49.09/26.12)	VDETAVfrRRSQSEDdnppspvTLDDPSGHGGGGSGTGGGNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.98|      38|      49|     928|     970|       5
---------------------------------------------------------------------------
  928-  970 (62.40/64.00)	PPY.RPAVMTSFTRMLNLPAKVLKdFIQIMRLDLMPELvqgnKW
  979- 1017 (69.58/52.94)	PPSaTPIVPVGTTTILSHRQKILF.FIQITRVPYMPNM....EW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.94|      38|     517|     341|     379|       6
---------------------------------------------------------------------------
  341-  379 (65.62/42.98)	FYGSpLPSLHHKEQG..MRRAVYLQYE..MQP..VESVSKVVDQL
  852-  895 (55.32/30.90)	FLGS.LMAITSNEPGvvVFKADCLQYQvfLNPnhMQSLHLKVDQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.71|      24|     368|      11|      39|       7
---------------------------------------------------------------------------
   11-   39 (37.32/51.81)	DWSK...LQHLISELRywiTQRRCEKtlQHLP
  382-  408 (42.40/35.13)	DWSKivyLYTLVHEFR...EQFNNEK..YNLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.74|      15|      19|     790|     804|       9
---------------------------------------------------------------------------
  790-  804 (29.41/17.71)	PGQSPEHKVQTSHHY
  810-  824 (27.33/15.84)	PARSWAGATPTTLTY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08112 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FRRRSQSEDDNPPSPVTLDDPSGHGGGGSGTGGGNNGGAGGGGGGGGTGGGSNTFLSGGTGMRGPQSPRDPGLRFAAPLTPPTSSNPHTPASPHPIGGGGGGGAGPGGAGGGGAGGAGGQGGQQQGHMNNFNMTSPPASHMPHPSPSGGLMPSSPLNAQPSPMAAHSPGPSSLPYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYTSRVLPAR
2) LLTLPQPKPPQAPTSAQQQQQQQSGAGGSDAKAAAAASSGNEPKPVHV
3) LTLPNEPPGQMQMQMGGVMQPGGGPGGPGGPGGPMGGQIGGPSPQVVPQVGSSPSPMMHSPMQQMGGGGQQPGGYGGMVGGPGGGPQSGGPGGGGPN
583
255
1084
812
302
1180










Molecular Recognition Features






MoRF SequenceStartStop




1) YGGMVGGPGGGPQSGGPGG
1158
1176