<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08103

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSAELRIVKLFEEVLEDKNIVPSFDEEEQRKKTEEGYKKIGTLFGAMTPEVKEASIRSYLGYVATVNHQNRVHNYLQVMNRMVALNIIPAKLLCDQLMCSEKLVYKNPCFWIEAFRLIRKVIGGVDYKGVREIMKCCKEKALSFPANVSVNILPQLLELIELIEHIFNRNACLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSAMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDEELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMEYSEKEGAQSQSAAGGALNEHDNDQSHTQWVWLHLSSQLIYFVLFQFATFQNIVNALHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKEPLPVPDNNNPNCTHQMAPTCIWIHLMKRAQTENYNINRPIPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMVGGGVQPLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYLSEPKPPGNIVSAESEELNRALILTLARSMHITGTGNDPQSSAWCKDLLQNIMLNTPHAWPQHTLYCFPPVLNEFFMQHNIPKESKQLLKKTVDEEYRNWASMTNENDIIAHFGMTVNPPLFLCLVFKMIIETDVISPVAYKILERIGARALSTHLRKMCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIVTIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTSEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPTLPVYFGNVCLRFLPVLDIIVHRFLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWALTEAYQAYVMTKETDNVNWVPELTYYINLVRRMQDTMDGKNVFSGTDWRFNEFPNPPAHALYVTCVELLGLPVGPNVVANSIIDVLVKGYTVVPNAVIHNWANTIGLIMAALPEAYWSVIYERMQGALNSKSMKEWAYRQSPFEMFNFKI
Length1204
PositionTail
OrganismAnopheles maculatus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles> Anopheles maculatus group.
Aromaticity0.10
Grand average of hydropathy-0.116
Instability index45.11
Isoelectric point7.62
Molecular weight138587.16
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08103
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     203.05|      44|      44|     300|     343|       1
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  300-  343 (75.29/49.06)	QLVWLVLNAMEYSEKEGAQSQSAAGGALNEHDNDQSHTQWVWLH
  347-  388 (64.10/40.61)	QLIYFVL..FQFATFQNIVNALHEKLAVRNLRRGRDHLMWVFLQ
  403-  441 (63.66/40.27)	.LPILKLYDILYPEKEPLPVPDNN....NPNCTHQMAPTCIWIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.23|      19|      90|    1075|    1094|       2
---------------------------------------------------------------------------
 1075- 1094 (31.47/23.49)	PElTYYINLVRRMQDTMDGK
 1167- 1185 (35.76/22.16)	PE.AYWSVIYERMQGALNSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     242.76|      81|     157|       5|     103|       4
---------------------------------------------------------------------------
    5-  100 (121.83/105.39)	LRIVKLFEEVLeDKN..IVPSFDEEEQRKKTEegYKKIGTLFGAMTPE.....VKEASIRSYLGYVA...TVNHQNRVHNylqvmnrmvalnIIPAKLLCDQLMCS
  157-  248 (120.93/68.48)	LELIELIEHIF.NRNacLLPAYFIINEIKKTD..YQNMHWRVSNLTANfieefVSVAQMLSIIGHSAmlpIVEHSSYADN...........lIIPWKLDPDTLKLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.63|      51|     157|     484|     536|       5
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  484-  535 (86.71/56.95)	SEYRFALLCNAYSTQTDYFSRPM......................QALIDTILGNSKnPQANMVGGGVQPLPTA
  635-  707 (75.93/40.81)	SHYRVQLLTHLHSLASVPHTNQMqlhscvestalrliiglgsvevQAQLSRYLSEPK.PPGNIVSAESEELNRA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08103 with Med23 domain of Kingdom Metazoa
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