<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08101

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLVPKLHEHYHQGPLQEKPSTASTGSSSGMSSAGSGLGMGAGTGGSNPSSIPPPLSSPAGSMHSPAGGNPVGGSIHGQQQQQQQPISPQEEQRIAQRQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLHDFVQSERFCRRLAYAVSKKLAQLINQMAESHNINLSSPEPDGNGKPPSNEMSDSKQEKQHDKAPKEGTNGGSAVQPADPIPPKVNPFEMIFTEYLHCSHHRDVVLQLSSILQVVTLECSTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPMPNRYEKSNEDIRRQLFEAEESIKVRSRHAESRWCIDKWQTAAGNASLKILATLDALDGHCFDRMDSNNSLDSLYSKIFPPFQVQQIKPTESTGGASGSGQGNVAPGGISAADGKDAATKQFEYNVEQDSSIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVLNALENDSYTNNLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLEESGSSQNKSQFTNLVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDSHGICNAGLGTGPISNKPATSSSPNNGGGMEDDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHATPSVTGLGKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFESTSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAIGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVELQLIGKSSMALVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKSRPQQEPFHNAYPKIKQALYTPLQPTPSAHTYNPQFMIEIITNPRRGGKIESGWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGTGKRSGLNTPVHPGSTPKSMAGSGDLSHILGTSDLSILGNPDESMLDVSQQNSHLNQENATSLSDFAQHVLRQICSQEWVLERCLQHAEELCQHGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSPDLSNWLDMVARAAIDVFRVNEFVLSNPDAKQEKIKPSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKHKDGNGGNSSSNNNSHNHGANSNSSVSSNGSTFGGKKSSQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYSQLSQFLQNRDQSLETIGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVLTCDSAGSSTDAKGNKIAIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIELNRFDRPQLNTNSKQALSIMLRSKQPINSGHPGSFMQQQQQQQQQQQQPQRNPQQQFMRGPIRAGMPGNPIVGAQAGMGPMNPAMAGGNAGIGATGGAAVMGAQGMNAGGMMGAQQATQGQQTAGGIMNQNTPAMMGTTGGSIMGQSGGSMIQTSMMNPQQNPTLVGQGMGSGGGIGS
Length2055
PositionKinase
OrganismAnopheles maculatus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles> Anopheles maculatus group.
Aromaticity0.06
Grand average of hydropathy-0.389
Instability index46.93
Isoelectric point6.33
Molecular weight225026.22
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08101
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.88|      34|     431|    1584|    1617|       1
---------------------------------------------------------------------------
  367-  393 (33.04/13.40)	........QMAEShnINLSSPEPD....GN.GKPPSNEMS
 1584- 1617 (60.72/30.80)	GRILKVSGQVLES..TSMFSKHKD....GNGGNSSSNNNS
 2018- 2046 (32.13/12.83)	GSIMGQSGGSMIQ..TSMMNPQQNptlvGQG.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.68|      13|     202|     475|     487|       2
---------------------------------------------------------------------------
  475-  487 (25.47/12.42)	SVLSGSPLD.HLPV
  679-  692 (21.21/ 9.03)	SVLSGSGLNgGQPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     192.37|      35|     560|     211|     249|       3
---------------------------------------------------------------------------
  211-  245 (64.41/29.50)	TGSSSGMSSA...GSGL.G.....MGAGT.G......GSNP.SSIPPPLSSP
  753-  786 (43.32/15.96)	TGAGGMLSLD...SHGIcN.....AGLGT.G.........PiSNKPATSSSP
 1367- 1407 (39.06/13.22)	TGKRSGLNTPvhpGSTP.K.....SMAGS.GdlshilGTSD.LSI...LGNP
 1977- 2016 (45.58/25.10)	VMGAQGM.NA...GGMM.GaqqatQGQQTaG......GIMN.QNTPAMMGTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.83|      51|     560|     533|     596|       4
---------------------------------------------------------------------------
  533-  592 (74.15/76.37)	QTAAGNAsLKILATLdALDGHCFdrmdsnnSLDSLYSKIFPPFQVQQIKPT.EST....GGASGS
 1231- 1286 (78.68/45.45)	NTNIHNA.LSVFTSI.LVARHCF.......SLENFVAHVALPSLVQACKGRgETTpeieAGARLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.38|      28|      39|    1433|    1464|       5
---------------------------------------------------------------------------
 1433- 1464 (41.84/41.56)	AQHVLRQICSQEwvLERCLqhAEELCQHGMLI
 1473- 1500 (49.54/32.24)	AQRLLHMICYPE..HESNL..IAELDQKAIIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      56.79|      10|      35|    1901|    1910|       6
---------------------------------------------------------------------------
 1863- 1872 (18.56/ 7.23)	PAPLSWAWFG
 1901- 1910 (20.12/ 8.43)	KQPINSGHPG
 1936- 1945 (18.12/ 6.89)	RGPIRAGMPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.86|      11|      34|    1523|    1536|       7
---------------------------------------------------------------------------
 1523- 1536 (14.32/18.14)	KQTNCsSPdlSNWL
 1560- 1570 (21.55/11.56)	KQEKI.KP..STWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.36|      24|    1649|     261|     286|       9
---------------------------------------------------------------------------
  261-  286 (42.21/31.77)	SIHGQQQQQQQpiSPQEEQRIAQRQW
 1911- 1934 (48.15/29.33)	SFMQQQQQQQQ..QQQQPQRNPQQQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.14|      35|     300|     401|     438|      11
---------------------------------------------------------------------------
  401-  438 (60.41/47.39)	HDkAPKEGTNGGSavQPADPIPPKVNPF.EMI....FTE..YLHC
  703-  744 (51.73/30.57)	HD.APVLEESGSS..QNKSQFTNLVHLFsELIrhdvFSHdaYMCC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08101 with Med12 domain of Kingdom Metazoa
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