<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08094

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSSGTAAVSGGSLPALLMANGGGGGVGGGGGGGGGGVGVGKGIGKPDTKPPGSGNTAGGAGTTGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFPEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSVQHFPDVHSQLLKAPLGVVQKRRGGHPMRLTYFVPPYELLDLGTRTLNALSAELIAKERIGCSVAVVLEASSANKLQIQPLLVGNGGGNAAPLSGTGQPVYTPIEKHNSTSLPATFVLRLNKPMPINGAMMRAIRGIVGGSEQQPGGDATTSTNNSSSNGGLPTSLLGLIAHHASGGSVTDLAKGLLVTLPDQYHCYHLMDNPLLRGVMVSSIPFTEPQHVPKILTYLRQQAIFNQLLSSCIRSNVSPAGGGRPSALQLLLDSGVYTIENGSSYGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANIVVRIYCSEGETSDEHTLDRLSAVLQRCMSIPVTLRALMKHWEEEHEQKFKPNVLGGAAITSSGGGGGPGGGIGGAGGGGDGSGTPGGGGAGVAGPGDDGSMNGFNLSSLGGAASTVDGAGGGGGGSAATNGTSAQQSSNQRGLMNGEGSLGLDFCDMLTERNGNGLGALGGNGRVGGGLGTREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVGGGGSDGGGSGGLEKVHVTGTVTNTTNTTTVTGQDVAAVTVNSEQRMQAGGATEEDTGGLPLFGETAPLGGVDAKGSSLGGTITNTILSAKNEPLPSVLPTNDDGGGGGGDEPAKMPLQSSSSSSLSSLSSSGFSLTGGAPAGEPTSERPCPGTLLLESLESATLELDSVKKSSGQSAKRRRSSSSSSSSSSSSSSSSSSSSSTSAASDEMEESVDLVEAEMSSFFAEVNNTQPVVAAAGMPAKGSYGSPSGKPALGAVSPISGKVVSPAGSTGLEKPIVPIGSNSSGLEIIPLTTGSTNITTPIANTPITTASQILANSASSATLTTTSTSTKKSSSSSSSSGGAHRKPSSESSERSSSGKSEKKKKRKVDDSGHLAMGPPNKLPFKAGESSPHRSSGLGGTSGSSSNKASPKRTSPVHHSSPKHTGSGALGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGTKSSDASGGSGGGGGGGGGISMSSTGGSSKERDKERSEKKALQ
Length1291
PositionMiddle
OrganismAnopheles maculatus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles> Anopheles maculatus group.
Aromaticity0.03
Grand average of hydropathy-0.313
Instability index54.69
Isoelectric point8.32
Molecular weight130204.72
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08094
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     342.37|      50|    1231|       1|      50|       2
---------------------------------------------------------------------------
    1-   50 (93.09/25.96)	MSSSGTAAVSG.GSL.....PALLMANGGGGGVGGGGGGGGGGVG.......V..GKGIGKPDTK
  611-  644 (48.71/10.04)	........VLG.G........AAITSSGGGGGPGGGIGGAGGG.G...........DGSGTPG..
  658-  693 (41.70/ 7.53)	.......SMNG.FNL.....SSL....GGAASTVDGAGGGGGGSA.......A..TNGTSAQ...
  695-  755 (44.09/ 8.38)	.SSNQRGLMNGeGSLgldfcDMLTERNGNGLGALGGNGRVGGGLGtreppepL..AGGAAKKRR.
  818-  855 (40.82/ 7.21)	MQAGGATEEDT.GGL.....P.LFGETAPLGGVDAKGSSLGGTIT....................
 1234- 1282 (73.96/19.10)	MSALKSAAASG.SS......PG.TKSSDASGGS.GGGGGGGGGIS.......MssTGGSSKERDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.14|      16|      17|    1020|    1035|       3
---------------------------------------------------------------------------
 1020- 1035 (25.48/ 9.01)	SPSGKPALGAVSPISG
 1164- 1179 (25.66/ 9.15)	SPHRSSGLGGTSGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.89|      21|      21|    1184|    1204|       4
---------------------------------------------------------------------------
  763-  783 (32.53/ 7.91)	PKSDSNLSVGGGGSDGGGSGG
 1184- 1204 (33.19/ 8.22)	PKRTSPVHHSSPKHTGSGALG
 1208- 1228 (33.17/ 8.21)	PKHGSSVSPKHPLHSGGSSTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.20|      19|      20|     940|     958|       5
---------------------------------------------------------------------------
  940-  958 (28.61/ 7.40)	SVKKSSGQSAKRRRSSSSS
  961-  979 (30.60/ 8.33)	SSSSSSSSSSSSSSTSAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.41|      20|      20|     124|     143|       7
---------------------------------------------------------------------------
  124-  143 (36.49/23.91)	LQKTLDSMQYCIKVTTRQGL
  501-  520 (34.92/22.55)	LQLLLDSGVYTIENGSSYGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.96|      17|      20|     417|     435|       8
---------------------------------------------------------------------------
  417-  435 (22.99/15.92)	HASggSVTD..LAKGLLV.TLP
  439-  458 (22.97/ 8.95)	HCY..HLMDnpLLRGVMVsSIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.43|      39|     731|     305|     346|       9
---------------------------------------------------------------------------
  305-  346 (57.28/35.92)	GCSVAVVLEASSANKLQIQPLLVGNgGGNAAPLSGTgqPVYT
 1045- 1083 (67.15/32.55)	GLEKPIVPIGSNSSGLEIIPLTTGS.TNITTPIANT..PITT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08094 with Med1 domain of Kingdom Metazoa
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