<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08086

Description Mediator of RNA polymerase II transcription subunit 28
SequenceMASSSNVSGNLVDELEEAFQSCIHALTKEESATGIDKDEIKVEVDQTTLKFIDLARQMEAFFLQKRFLLSALKPDLLLKEENFDLKQEIGRKDELIRKHYEKIESWKQLLSDQQNFNKPIQSMPPDMRGNLAGGAPGAPAGLMAGGGMNLPMQVNKSMQNQHQQQMQQMQVQQQQMQQQMQQSMPMGATNAQLFQQGGMPRGVGQAGSGAGFPQGAGPNLQGPLAYLEKTASNIDLVGLGDGRR
Length244
PositionHead
OrganismAnopheles funestus (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.593
Instability index50.36
Isoelectric point5.47
Molecular weight26833.22
Publications
PubMed=21129198
PubMed=31157884

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08086
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.15|      46|      59|     107|     159|       1
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  107-  152 (88.34/43.35)	KQLLSDQQNFNKPI.QSMPPDM.......RGNLA.G.GAPGAPAGLMAGGGMNL..PM
  167-  224 (65.80/22.68)	QQMQVQQQQMQQQMqQSMPMGAtnaqlfqQGGMPrGvGQAGSGAGFPQGAGPNLqgPL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08086 with Med28 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QNFNKPIQSMPPDMRGNLAGGAPGAPAGLMAGGGMNLPMQVNKSMQNQHQQQMQQMQVQQQQMQQQMQQSMPMGATNAQLFQQGGMPRGVGQAGSGAGFPQGAGPNLQGPLAYL
114
227










Molecular Recognition Features






MoRF SequenceStartStop




NANANA