<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08084

Description Uncharacterized protein
SequenceMTTAVMMDYDFKMKTQQERAKVEDLFEYEGCKVGRGTYGHVYKARRKEGNDTKDYALKQIEGTGLSMSACREIALLRELKHPNVINLIRVFLSHTDRKVWLLFDYAEHDLWHIIKFHRAAKATKKPVMVPKGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIRKMPEHHTLTKDFKRSNYASCSLVKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDPYFSEDPMPTADVFAGCPIPYPKREFLTDEDQDDKGEKRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNNQQQNNQQQNQQGNQQQQQQQQQQQQQQQQNQQNTQQQQSGNQMQQGGGGGGGAGGAGGGSGGGQSGGGGIDHNNAKRVRLSGPNGHPNNSQGGMTQQEYHQQQQQQQQNQQQQQQQNQMMFNNAQQGGFQQRY
Length541
PositionKinase
OrganismAnopheles funestus (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.08
Grand average of hydropathy-1.071
Instability index61.45
Isoelectric point8.76
Molecular weight62423.09
Publications
PubMed=21129198
PubMed=31157884

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08084
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     143.05|      16|      16|     378|     393|       1
---------------------------------------------------------------------------
  378-  393 (36.74/ 9.89)	QQQQQQQQQQQQQQQQ
  395-  410 (35.79/ 9.46)	QQQQQQQQQQQQNNQQ
  425-  440 (36.40/ 9.73)	QQQQQQQQQQQQQNQQ
  510-  525 (34.12/ 8.70)	QQQQQQQNQQQQQQQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.21|      14|      18|     447|     460|       2
---------------------------------------------------------------------------
  447-  460 (27.17/13.28)	SGNQMQQGGGGGGG
  464-  477 (23.55/10.43)	AGGGSGGGQSGGGG
  482-  495 (21.49/ 8.80)	NAKRVRLSGPNGHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.94|      16|      26|     245|     267|       3
---------------------------------------------------------------------------
  245-  262 (22.79/33.82)	EDIKtSNPYHHdQLDRIF
  274-  289 (31.16/15.38)	EDIR.KMPEHH.TLTKDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.93|      12|      33|     496|     507|       4
---------------------------------------------------------------------------
  496-  507 (24.40/11.20)	NNSQGGMTQQEY
  530-  541 (24.54/11.31)	NNAQQGGFQQRY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08084 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PNKRITSEQAMQDPYFSEDPMPTADVFAGCPIPYPKREFLTDEDQDDKGEKRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNNQQQNNQQQNQQGNQQQQQQQQQQQQQQQQNQQNTQQQQSGNQMQQGGGGGGGAGGAGGGSGGGQSGGGGIDHNNAKRVRLSGPNGHPNNSQGGMTQQEYHQQQQQQQQNQQQQQQQNQMMFNNAQQGGFQQRY
326
541










Molecular Recognition Features






MoRF SequenceStartStop




1) NTQQQQSGNQM
2) QQEYHQQQQ
3) QSGGGGIDHNNAKRVRLSGPNGH
441
504
472
451
512
494