<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08075

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSSGTAAVSGGTLPALLMANGGSVGGGGVGTGKGIGKPDIKPPGSGPTVGGSGGTTGKVLLGGDKHETWQMELLMERLRTKAKSAQYKTFPEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSLQHFADVHSQLLKAPLGVVQKRRGGHPMRLTYFVAPYELLDVGTRIINTLSPELIAKERIGCSVAVVLEASSANKLQIQPLLVVNGSGSVTSVGQPVYTPIEKHNSTSLPATFVLRLNKPMPINGAMMRAIKTIVGGSSGANEQQGGEGTVTGSTGLPTSLLGLIAHHASGGSVTDLAKGLVVSLPDQYHCYYLTDNPLLRGVMVSSIPFTEPQHVPKILTYLRQQAIFNQLLSSCIRSTSSAAGGAGGRPSALQLLLDGGTHTIENGTVGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANIIVRIYCSEGESSDEHTVERLSAVLQRCMSIPVTLRALMKHWEEEHEQKFKPNVLGASTVSSAGGGGGPGGTGGGLNGGGDGTGTGGGVGSSGEDGSMNGFNLSSLGGPASTVDGAGGVGGAGVGGGGGGGGSAATNGTSAQQTVGQRGLMNGEGNGLVASANLGLDFCDMLAERNGNGLGGSMGRVAGQGLGTREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVAVVGVTDGSGVEKANVTTATTGVTTVTSQDVAVAAAAATSGGTAAGNSEQRMQAGGATEEDTGGLPLFGETVPVGGADAKGSSLGGTTITNTTASAKNEPPSVLPADDESAIVGTGVKMPLQSSSSSSLSSLSSSGFSLTGVASGDASSDRPCPGTLLLESLESAALETDPPKRTTGQSVKRRRSSSSSSSSSSSSSSSSSSSSTTSGATDEVEESVDLVEAEMSSFFAEVNSAQPIAAATPKGTFGSGPSGKPSLGPVSPIAGKLVSPSGSGGIEKPLATISSSGLEIIPIPTGHTNIAASAFSSTTVTTNTPITVPQIIANSTSATSLTTTSTATKKTSSSSSSSSNSSSSSSHRKGTESTERSSSSKSDKKKKRKVDDSGHLAMGPPNKLPFKSGESSPHRSGIGGSSSSSGNKSSPKHSSPVHHSSPKHTGSSALGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGTKSSETSGAGVAGGGGGGGSGLSISTTSGSSKERDKERSEKKTLQFSATSASAGSSLTSSSTGSSGSGSGGRSKSSGLKLKQLDLTAGSSMTISMTGSGIGDSGSSSPVAPMIDLTGPGSLQGSSLGSLGLSSTGLTTASSMLQALQAAKNRKPPSSAGGTGLGGSLSAVIDKLKSAQSADDEAVLVLPEMTITQQTTSTSLAAGSGGIGAGVNIGGFGSISGGGTLKDPSKTGSSLLSATGSGTLANCVSSTTAIGAALTQASSMTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSSKSSSNSGGGSKSGSSGSNKSGLKSGVSSGPVSSKQQQQNHTTSFSGAFPSSTKTPHYTSSSSKTPFQKSNSFGSLGGGGGGGSGGIGMKSSKVSSPKSTSNPASSSSSSYSSKEKGGPASGRSKSSSASSLTGAAMLGGGGTAGGAGSGAGSSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNNNAGTGSAGHSEGNDGTKSMKDSAVRKQKPQLPITASTSQSVGSSPLRSFSTSPSSGDASARLLSDLLGAAAKNSTKMSASGTGPTGGPSIDGGGGGGGTALHPLLPNIVQKMFGSDGSLQSKSNSSDGSMFPSAGRASPGMLSGSASRDGFRSGTGSAPGTPTTTGSMVLPPFPSPVSGGASNDGDAGSGAGSLMRPPSRPSSTISNHSHSSQDGIGGSVGDVGPSPVVTSMASMMMMSAMSAAGGQSPASGSLSLDSASTQQLIAALAAKSGAAGGGGGGGGGVLPPPNSLLNNHTHLHHHGNHLNNHVVGGTTPSLNNLPSPASVSVHLVKSPAPSPLPFTSPHSNASSTHGGPAGGGLDDDLMDEALIGIGSK
Length2147
PositionMiddle
OrganismAnopheles funestus (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.257
Instability index50.92
Isoelectric point9.10
Molecular weight212420.28
Publications
PubMed=21129198
PubMed=31157884

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08075
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     489.28|      61|      61|    1599|    1659|       1
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  906-  988 (51.28/ 7.80)	PLQSSSSSSLSSLSSSGF.......S........LTGV.............ASGD......ASSDR........PcpgtllleslesaaletdppkrttgqsV.......KRRRS..SSSSSSSSSS...S.SSS..SSS
 1205- 1258 (68.17/13.65)	SPKHSSPVHHSSPKHTGS.......S........ALGF...H.......SPKHGS......S........................................V.......SPKHP..LHSGGSSTGG...GKP.S..MSA
 1259- 1328 (55.20/ 9.16)	LKSAAASGSSPGTKSSETS......G........AGVA...G.......GGGGGG.sglsiSTTSG........S...........................SkerdkerSEKKT..LQFSATSASA...G..SS..L.T
 1329- 1404 (57.34/ 9.90)	SSSTGSSGSGSGGRSKSSGlklkqlD........LTAG...SsmtismtGSGIGD......SGSSS........P...........................V.......APMID..LTGPGSLQGS...SLGSLglSST
 1465- 1522 (60.03/10.83)	QQTT.STSLAAGSGGIGAG......V........NIGG...F.......GSISGG......GTLKD........P....................................SKTGssLLSATG..SG...TLANC..VSS
 1629- 1690 (86.37/19.96)	PHYTSSSSKTPFQKSNSFG......S........LGGG...G.......GGGSGG.....iGMKSS........K...........................V.......SSPKS..TSNPASSSSS...SYSSK..EKG
 1691- 1758 (57.26/ 9.87)	GP.ASGRS.....KSSSAS......S........LTGAamlG.......GGGTAG......GAGSGagssalvnP...........................I.......SIMKM..LGYPTGSM.GnmeGFAKS..LDT
 1809- 1882 (53.63/ 8.61)	SQSVGSSPLRSFSTSPSSG......DasarllsdLLGA...A.......AKNSTKmsasgtGPTGG........P...................................SIDGG..GGGGGTALHP...LLPNI..VQK
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     421.59|      82|    1361|     611|     692|       2
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   11-   59 (48.32/ 6.36)	...............................GGtlPALLMANGGSVGGGGVG.......TGK.GIG...KPDI..........................K..PPGSGptvGGSGGTTGK
  636-  692 (92.53/20.00)	LNGGGDGTGTGGGVGSSGEDGSMNGFNLSSLGG..PASTVDGAGGVGGAGVG.......GGGGGGG.....................................................
  693-  760 (67.64/12.32)	.SAATNGTSAQQTV...GQRGLMNG......EG..N.......GLVASANLGldfcdmlAERNG.......NG....................LGGSMGR..VAGQG...LGTREPPEP
  761-  837 (54.94/ 8.40)	LAGG............AAKKRRMEDFCKS......PKS..DSNLSVAVVGVT.......DGSG..........vekanvttattgvttvtsqdVAVAAAA..ATSGG...TAAGNSEQR
 1917- 1993 (107.22/24.53)	ASRDGFRSGTGSAPGTPTTTGSM...VLPPFPS..PVS..GGASNDGDAGSG.......AGSLM.....RPPS....................RPSSTISnhSHSSQ...DGIGGSVGD
 2012- 2061 (50.93/ 7.16)	MSAAGGQSPASGSLSL............DSAST..QQLIAALAAKSGAAG.G.......GGGGGGGvlpPPN...............................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.12|      14|      17|     841|     857|       4
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  839-  855 (21.17/16.30)	QA...GGAteeDTGGLPLFG
  856-  872 (18.95/ 6.03)	ETvpvGGA...DAKGSSLGG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.23|      46|     218|     257|     305|       5
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  257-  305 (73.64/44.62)	VHSQLLKAPLGVVQKRRGGHPMRLTYFVApyeLLDVGTRIIN..TLSPELI
  478-  525 (72.58/36.57)	IFNQLLSSCIRSTSSAAGGAGGRPSALQL...LLDGGTHTIEngTVGGLLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     136.92|      36|     567|    1540|    1583|       7
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 1540- 1559 (22.09/ 9.45)	..........................PSLTAALTSGKASEYMVKPS
 1568- 1606 (36.28/ 7.93)	QNKKGSSKSSSNSGGGsksgssgsnkSGLKSGVSSGPVS.......
 1761- 1783 (32.57/ 6.03)	QIPKLSARSNNNAGTG..........S...AGHSEG..........
 1888- 1916 (45.97/10.86)	....GSLQSKSNSSDG..........SMFPS...AGRASPGMLSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.11|      15|     218|     873|     897|       8
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  873-  888 (23.16/ 8.64)	TTITnTTASAKNEPPS
 1114- 1128 (22.94/ 7.70)	TSLT.TTSTATKKTSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.68|      35|     611|     413|     459|      10
---------------------------------------------------------------------------
  413-  450 (52.86/26.41)	GLIAHHASG....GSVTDLAKGLVVSLPDQYHCyyLtDNPLL
 1030- 1066 (51.12/16.25)	GTFGSGPSGkpslGPVSPIA.GKLVS.PSGSGG..I.EKPLA
 1084- 1105 (25.70/11.40)	N.IA..ASA....FSSTTVTTNTPITVPQ.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.21|      18|      18|    2080|    2097|      11
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 2080- 2097 (33.20/18.14)	HVVGGTTPSLNNLPSPAS
 2101- 2118 (35.01/19.64)	HLVKSPAPSPLPFTSPHS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.23|      17|      17|     106|     122|      20
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  106-  122 (26.52/17.10)	RYALDAVEKSNLQKTLD
  125-  141 (28.71/19.11)	QYCIKVTTRQGLVERLD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08075 with Med1 domain of Kingdom Metazoa
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