<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08075

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSSGTAAVSGGTLPALLMANGGSVGGGGVGTGKGIGKPDIKPPGSGPTVGGSGGTTGKVLLGGDKHETWQMELLMERLRTKAKSAQYKTFPEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSLQHFADVHSQLLKAPLGVVQKRRGGHPMRLTYFVAPYELLDVGTRIINTLSPELIAKERIGCSVAVVLEASSANKLQIQPLLVVNGSGSVTSVGQPVYTPIEKHNSTSLPATFVLRLNKPMPINGAMMRAIKTIVGGSSGANEQQGGEGTVTGSTGLPTSLLGLIAHHASGGSVTDLAKGLVVSLPDQYHCYYLTDNPLLRGVMVSSIPFTEPQHVPKILTYLRQQAIFNQLLSSCIRSTSSAAGGAGGRPSALQLLLDGGTHTIENGTVGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANIIVRIYCSEGESSDEHTVERLSAVLQRCMSIPVTLRALMKHWEEEHEQKFKPNVLGASTVSSAGGGGGPGGTGGGLNGGGDGTGTGGGVGSSGEDGSMNGFNLSSLGGPASTVDGAGGVGGAGVGGGGGGGGSAATNGTSAQQTVGQRGLMNGEGNGLVASANLGLDFCDMLAERNGNGLGGSMGRVAGQGLGTREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVAVVGVTDGSGVEKANVTTATTGVTTVTSQDVAVAAAAATSGGTAAGNSEQRMQAGGATEEDTGGLPLFGETVPVGGADAKGSSLGGTTITNTTASAKNEPPSVLPADDESAIVGTGVKMPLQSSSSSSLSSLSSSGFSLTGVASGDASSDRPCPGTLLLESLESAALETDPPKRTTGQSVKRRRSSSSSSSSSSSSSSSSSSSSTTSGATDEVEESVDLVEAEMSSFFAEVNSAQPIAAATPKGTFGSGPSGKPSLGPVSPIAGKLVSPSGSGGIEKPLATISSSGLEIIPIPTGHTNIAASAFSSTTVTTNTPITVPQIIANSTSATSLTTTSTATKKTSSSSSSSSNSSSSSSHRKGTESTERSSSSKSDKKKKRKVDDSGHLAMGPPNKLPFKSGESSPHRSGIGGSSSSSGNKSSPKHSSPVHHSSPKHTGSSALGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGTKSSETSGAGVAGGGGGGGSGLSISTTSGSSKERDKERSEKKTLQFSATSASAGSSLTSSSTGSSGSGSGGRSKSSGLKLKQLDLTAGSSMTISMTGSGIGDSGSSSPVAPMIDLTGPGSLQGSSLGSLGLSSTGLTTASSMLQALQAAKNRKPPSSAGGTGLGGSLSAVIDKLKSAQSADDEAVLVLPEMTITQQTTSTSLAAGSGGIGAGVNIGGFGSISGGGTLKDPSKTGSSLLSATGSGTLANCVSSTTAIGAALTQASSMTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSSKSSSNSGGGSKSGSSGSNKSGLKSGVSSGPVSSKQQQQNHTTSFSGAFPSSTKTPHYTSSSSKTPFQKSNSFGSLGGGGGGGSGGIGMKSSKVSSPKSTSNPASSSSSSYSSKEKGGPASGRSKSSSASSLTGAAMLGGGGTAGGAGSGAGSSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNNNAGTGSAGHSEGNDGTKSMKDSAVRKQKPQLPITASTSQSVGSSPLRSFSTSPSSGDASARLLSDLLGAAAKNSTKMSASGTGPTGGPSIDGGGGGGGTALHPLLPNIVQKMFGSDGSLQSKSNSSDGSMFPSAGRASPGMLSGSASRDGFRSGTGSAPGTPTTTGSMVLPPFPSPVSGGASNDGDAGSGAGSLMRPPSRPSSTISNHSHSSQDGIGGSVGDVGPSPVVTSMASMMMMSAMSAAGGQSPASGSLSLDSASTQQLIAALAAKSGAAGGGGGGGGGVLPPPNSLLNNHTHLHHHGNHLNNHVVGGTTPSLNNLPSPASVSVHLVKSPAPSPLPFTSPHSNASSTHGGPAGGGLDDDLMDEALIGIGSK
Length2147
PositionMiddle
OrganismAnopheles funestus (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.257
Instability index50.92
Isoelectric point9.10
Molecular weight212420.28
Publications
PubMed=21129198
PubMed=31157884

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08075
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     489.28|      61|      61|    1599|    1659|       1
---------------------------------------------------------------------------
  906-  988 (51.28/ 7.80)	PLQSSSSSSLSSLSSSGF.......S........LTGV.............ASGD......ASSDR........PcpgtllleslesaaletdppkrttgqsV.......KRRRS..SSSSSSSSSS...S.SSS..SSS
 1205- 1258 (68.17/13.65)	SPKHSSPVHHSSPKHTGS.......S........ALGF...H.......SPKHGS......S........................................V.......SPKHP..LHSGGSSTGG...GKP.S..MSA
 1259- 1328 (55.20/ 9.16)	LKSAAASGSSPGTKSSETS......G........AGVA...G.......GGGGGG.sglsiSTTSG........S...........................SkerdkerSEKKT..LQFSATSASA...G..SS..L.T
 1329- 1404 (57.34/ 9.90)	SSSTGSSGSGSGGRSKSSGlklkqlD........LTAG...SsmtismtGSGIGD......SGSSS........P...........................V.......APMID..LTGPGSLQGS...SLGSLglSST
 1465- 1522 (60.03/10.83)	QQTT.STSLAAGSGGIGAG......V........NIGG...F.......GSISGG......GTLKD........P....................................SKTGssLLSATG..SG...TLANC..VSS
 1629- 1690 (86.37/19.96)	PHYTSSSSKTPFQKSNSFG......S........LGGG...G.......GGGSGG.....iGMKSS........K...........................V.......SSPKS..TSNPASSSSS...SYSSK..EKG
 1691- 1758 (57.26/ 9.87)	GP.ASGRS.....KSSSAS......S........LTGAamlG.......GGGTAG......GAGSGagssalvnP...........................I.......SIMKM..LGYPTGSM.GnmeGFAKS..LDT
 1809- 1882 (53.63/ 8.61)	SQSVGSSPLRSFSTSPSSG......DasarllsdLLGA...A.......AKNSTKmsasgtGPTGG........P...................................SIDGG..GGGGGTALHP...LLPNI..VQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     421.59|      82|    1361|     611|     692|       2
---------------------------------------------------------------------------
   11-   59 (48.32/ 6.36)	...............................GGtlPALLMANGGSVGGGGVG.......TGK.GIG...KPDI..........................K..PPGSGptvGGSGGTTGK
  636-  692 (92.53/20.00)	LNGGGDGTGTGGGVGSSGEDGSMNGFNLSSLGG..PASTVDGAGGVGGAGVG.......GGGGGGG.....................................................
  693-  760 (67.64/12.32)	.SAATNGTSAQQTV...GQRGLMNG......EG..N.......GLVASANLGldfcdmlAERNG.......NG....................LGGSMGR..VAGQG...LGTREPPEP
  761-  837 (54.94/ 8.40)	LAGG............AAKKRRMEDFCKS......PKS..DSNLSVAVVGVT.......DGSG..........vekanvttattgvttvtsqdVAVAAAA..ATSGG...TAAGNSEQR
 1917- 1993 (107.22/24.53)	ASRDGFRSGTGSAPGTPTTTGSM...VLPPFPS..PVS..GGASNDGDAGSG.......AGSLM.....RPPS....................RPSSTISnhSHSSQ...DGIGGSVGD
 2012- 2061 (50.93/ 7.16)	MSAAGGQSPASGSLSL............DSAST..QQLIAALAAKSGAAG.G.......GGGGGGGvlpPPN...............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.12|      14|      17|     841|     857|       4
---------------------------------------------------------------------------
  839-  855 (21.17/16.30)	QA...GGAteeDTGGLPLFG
  856-  872 (18.95/ 6.03)	ETvpvGGA...DAKGSSLGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.23|      46|     218|     257|     305|       5
---------------------------------------------------------------------------
  257-  305 (73.64/44.62)	VHSQLLKAPLGVVQKRRGGHPMRLTYFVApyeLLDVGTRIIN..TLSPELI
  478-  525 (72.58/36.57)	IFNQLLSSCIRSTSSAAGGAGGRPSALQL...LLDGGTHTIEngTVGGLLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     136.92|      36|     567|    1540|    1583|       7
---------------------------------------------------------------------------
 1540- 1559 (22.09/ 9.45)	..........................PSLTAALTSGKASEYMVKPS
 1568- 1606 (36.28/ 7.93)	QNKKGSSKSSSNSGGGsksgssgsnkSGLKSGVSSGPVS.......
 1761- 1783 (32.57/ 6.03)	QIPKLSARSNNNAGTG..........S...AGHSEG..........
 1888- 1916 (45.97/10.86)	....GSLQSKSNSSDG..........SMFPS...AGRASPGMLSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.11|      15|     218|     873|     897|       8
---------------------------------------------------------------------------
  873-  888 (23.16/ 8.64)	TTITnTTASAKNEPPS
 1114- 1128 (22.94/ 7.70)	TSLT.TTSTATKKTSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.68|      35|     611|     413|     459|      10
---------------------------------------------------------------------------
  413-  450 (52.86/26.41)	GLIAHHASG....GSVTDLAKGLVVSLPDQYHCyyLtDNPLL
 1030- 1066 (51.12/16.25)	GTFGSGPSGkpslGPVSPIA.GKLVS.PSGSGG..I.EKPLA
 1084- 1105 (25.70/11.40)	N.IA..ASA....FSSTTVTTNTPITVPQ.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.21|      18|      18|    2080|    2097|      11
---------------------------------------------------------------------------
 2080- 2097 (33.20/18.14)	HVVGGTTPSLNNLPSPAS
 2101- 2118 (35.01/19.64)	HLVKSPAPSPLPFTSPHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.23|      17|      17|     106|     122|      20
---------------------------------------------------------------------------
  106-  122 (26.52/17.10)	RYALDAVEKSNLQKTLD
  125-  141 (28.71/19.11)	QYCIKVTTRQGLVERLD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08075 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAATPKGTFGSGPSGKPSLGPVSPIAGKLVSPSGSGGIEKPLATISSSGLEIIPIPTGHTNIAASAFSSTTVTTNTPITVPQIIANSTSATSLTTTSTATKKTSSSSSSSSNSSSSSSHRKGTESTERSSSSKSDKKKKRKVDDSGHLAMGPPNKLPFKSGESSPHRSGIGGSSSSSGNKSSPKHSSPVHHSSPKHTGSSALGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGTKSSETSGAGVAGGGGGGGSGLSISTTSGSSKERDKERSEKKTLQFSATSASAGSSLTSSSTGSSGSGSGGRSKSSGLKLKQL
2) FAKSLDTKFQIPKLSARSNNNAGTGSAGHSEGNDGTKSMKDSAVRKQKPQLPITASTSQSVGSSPLRSFSTSPSSGDASARLLSDLLGAAAKNSTKMSASGTGPTGGPSIDGGGGGGGTALHPLLPNIVQKMFGSDGSLQSKSNSSDGSMFPSAGRASPGMLSGSASRDGFRSGTGSAPGTPTTTGSMVLPPFPSPVSGGASNDGDAGSGAGSLMRPPSRPSSTISNHSHSSQDGIGGSVGDVGPSPVVTSMASMMMMSAMSAAGGQSPASGSLSLDSASTQQ
3) GGVGTGKGIGKPDIKPPGSGPTVGGSGGTTG
4) GLGGSMGRVAGQGLGTREPPEPLAGGAAKKRRMEDFCKSPK
5) HEQKFKPNVLGASTVSSAGGGGGPGGTGGGLNGGGDGTGTGGGVGSSGEDGSMNGFNLSSLGGPASTVDGAGGVGGAGVGGGGGGGGSAATNGTSAQQTVGQRGLMNGE
6) IAALAAKSGAAGGGGGGGGGVLPPPNSLLNNHTHLHHHGNHLNNHVVGGTTPSLNNLPSPASVSVHLVKSPAPSPLPFTSPHSNASSTHGGPAGGGLDDDLMDEAL
7) KPSSDGIKLTIQNKKGSSKSSSNSGGGSKSGSSGSNKSGLKSGVSSGPVSSKQQQQNHTTSFSGAFPSSTKTPHYTSSSSKTPFQKSNSFGSLGGGGGGGSGGIGMKSSKVSSPKSTSNPASSSSSSYSSKEKGGPASGRSKSSSASSLTGAAMLGGGGTAGGAGSGAGSSAL
8) MTISMTGSGIGDSGSSSPVAPMIDLTGPGSL
9) SGVEKANVTTATTGVTTVTSQDVAVAAAAATSGGTAAGNSEQRMQAGGATEEDTGGLPLFGETVPVGGADAKGSSLGGTTITNTTASAKNEPPSVLPADDESAIVGTGVKMPLQSSSSSSLS
10) SSGFSLTGVASGDASSDRPCPGTLLLESLESAALETDPPKRTTGQSVKRRRSSSSSSSSSSSSSSSSSSSSTTSGATDEVEESVDLVE
1024
1752
28
739
606
2036
1557
1361
795
920
1353
2034
58
779
714
2141
1729
1391
916
1007










Molecular Recognition Features






MoRF SequenceStartStop




1) ALKSA
2) LKLKQL
3) LVNPI
1258
1348
1729
1262
1353
1733