<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08072

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDISWKTSNFRQSVVNKMYDKNKRERNEAIQETGMTSSRNGIEIENHVFLNARNKDEYLGFVARLILRIRDMKDISWKTSNFRQSVVNKMYDMDKRERNEAIQQTGMTSSKNGIEMENHVFHKARNKDEYLGFVARLILHVREMNTKHKNQQNAAAAAAQQAQQDGGGNANQQGGGGGGGGSGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGAGNASNLLHSLRPQMQMGGMGGPMQANRVGMGPGPGNQMGGMMGPNQMQGPGAGMVGGMPGQMGVGIGPGGMSGGKIVGMGGQQQQMAQLNAMQVNQMQQAQQQQQQQGGMPQSQQQQQQGGLVQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQSAMAGQQMGTVGGTMNAANQMGPMVGANAGMNPQAMGMAPNQVLRQQQQQQGMQQVQMGLGPGQMGQLNAGVQGGQQQQQQQQQQQHQQQQASAMGQTGPSQMNAGVAIGPGGGGVMGPVPNQMLGAGAGGAAGQQGNFVGMGANTMVRKPPDMMPGGNVYPGGGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMSGVAQRSNIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYRALTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILSNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAVSSSLQGASGNHTLQRTFRPCLEALFGPDIKNLPPPAKQPRLTQDESTIANGGTAGGVTSGGATNTTSTTTAVTSTASGGAATTGGAVSTNTTASTAPQEIPHILQGEIARLDQKFKVSLDQCAISGTRTIKLICWLDDKNLPCVPPVAVTIPEDYPVTAPSCSLIEQEYNATPFLILVQKSLMARICKLPGLFTLSHLLDTWEMSVRQACSPNPTIVAPTGTSVLLGM
Length944
PositionTail
OrganismAnopheles funestus (African malaria mosquito)
KingdomMetazoa
Lineage
Aromaticity0.03
Grand average of hydropathy-0.504
Instability index53.66
Isoelectric point9.33
Molecular weight98960.28
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08072
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     375.84|      69|      69|       4|      72|       1
---------------------------------------------------------------------------
    4-   70 (105.57/31.54)	.....DISWKTSNFRQSVV.......NKM.......YDKNKR.....ERNEAIQETG..MTSSR.NGI.EI.ENHVFLNARNKDEYLGFVARLILR
   71-  142 (113.27/34.39)	IRdmkDISWKTSNFRQSVV.......NKM.......YDMDKR.....ERNEAIQQTG..MTSSK.NGI.EM.ENHVFHKARNKDEYLGFVARLILH
  143-  207 (41.33/ 7.74)	VR.................emntkhkNQQnaaaaaaQQAQQDgggnaNQQGGGGGGG..GSGMP.DPInAL.QN..LASQGTRPQMMG........
  371-  427 (77.19/21.03)	.................VM.......GQI.......QAQLQN.....QSAMAGQQMGtvGGTMN.AAN.QM.GPMVGANAGMNPQAMGMAPNQVLR
  492-  531 (38.48/ 6.69)	.....................................................GPGG..GGVMGpVPN.QMlGAGAGGAAGQQGNFVGMGANTMVR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     127.54|      32|      32|     208|     239|       2
---------------------------------------------------------------------------
  315-  345 (46.59/11.32)	AMQVNQMQQAQQQQQQ......QGGM.PQSQQQ..QQQGG
  553-  584 (41.68/ 9.28)	VTPNNFLRQSPSPS.....vpsPVGPGAHGP.P..SHPGQ
  585-  624 (39.27/ 8.27)	MIPSPALIPSPNPHMSgvaqrsNIGQSPGGSLNtpGQPGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     197.30|      27|      34|     428|     454|       4
---------------------------------------------------------------------------
  258-  276 (32.46/ 7.94)	PGNQMGG.........M..MGPNQMQGPGA..
  291-  314 (34.54/ 9.08)	GPGGMSGGKIVG....MG.GQQQQMAQLN...
  348-  369 (34.38/ 8.99)	..QGQGGPVQ.Q....MG.VGPGGPNQMNP..
  428-  454 (57.42/21.61)	QQQQQQGMQQVQ....MG.LGPGQMGQLNAGV
  461-  489 (38.49/11.24)	QQQQQQQQHQQQqasaMGqTGPSQM...NAGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.37|      21|      23|     764|     785|       5
---------------------------------------------------------------------------
  211-  226 (27.35/ 6.89)	VGPGGPMGG.QMGGA..GN....
  764-  784 (37.81/14.41)	IANGGTAGGVTSGGA..TNTTST
  788-  810 (30.22/10.12)	VTSTASGGAATTGGAvsTNTTAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.23|      23|      23|     693|     715|       6
---------------------------------------------------------------------------
  693-  715 (37.50/24.56)	EAALTSQLGSIRETPTNNPLVEA
  717-  739 (39.73/26.52)	SSSLQGASGNHTLQRTFRPCLEA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08072 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALTSQLGSIRETPTNNPLVEAVSSSLQGASGNHT
2) AQLNAMQVNQMQQAQQQQQQQGGMPQSQQQQQQGGLVQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQSAMAGQQMGTVGGTMNAANQMGPMVGANAGMNPQAMGMAPNQVLRQQQQQQGMQQVQMGLGPGQMGQLNAGVQGGQQQQQQQQQQQHQQQQASAMGQTGPSQMNAGVAIGPGGGGVMGPVPNQMLGAGAGGAAGQQGNFVGMGANTMVRKPPDMMPGGNVYPGGGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMSGVAQRSNIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKY
3) NKMYDMDKRERNEAIQQTGMTSSKNGIEMENHVF
4) NLPPPAKQPRLTQDESTIANGGTAGGVTSGGATNTTSTTTAVTSTASGGAATTGGAVSTNTTASTAPQE
5) REMNTKHKNQQNAAAAAAQQAQQDGGGNANQQGGGGGGGGSGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGAGNASNLLHSLRPQMQMGGMGGPMQANRVGMGPGPGNQMGGMMGPNQMQGPGAGMVGGMPGQMGVGIGPGGMSGGKIVGMGGQQQQ
695
311
90
747
144
728
642
123
815
309










Molecular Recognition Features






MoRF SequenceStartStop




NANANA