<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08071

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSAELRIVKLFEEVLEDKNIVPSFDEEEQRKKTEEGYKKIGTLFGAMTPEVKEASIRSYLGYVATVNHQNRVHNYLQVMNRMVALNIIPAKLLCDQLMCSDKLVYKNPCFWIEAFRLIRKVIGGVDYKGVREIMKCCKEKALSFPANVSVNILPQLLELIELIEHIFNRNACLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSSMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDEELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMEYSEKEGTQAQNTASTALNEHDNDQSHTQWVWLHLSSQLIYFVLFQFATFQNIVNALHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKESLPVPDNSNPNCTHQMAPTCIWIHLMKRAQTENYNINRPIPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMVGGGVQSLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYLSEPKPPGNIVSAESEELNRALILTLARSMHITGTGNDPQSSAWCKDLLQNVMLNTPHAWPQHTLYCFPPVLNEFFMQHNIPKESKQLLKKTVDEEYRNWASMTNENDIIAHFGMTVNPPLFLCLVFKMIIETDVISPVAYKILERIGARALSTHLRKMCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIVTIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTTEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPTLPVYFGNVCLRFLPVLDIIVHRFLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWALTEAYQAYMMTKETDNVNWVPELSYYINLVRRMQDTMDGKNIFSGTDWRFNEFPNPPAHALYVTCVELLGLPVGPNVVANSIIDVLVKGYTVVPNAVIHNWTNTIGLIMAALPEAYWSVIYERMQGALNSKAMKEWTYRQSPFEMFNFKIVKESMLDRSYVTVLAIVHSIFHHFGIGQLATVTESLKEKLKPLVHTEYQLIYVCHVVGPFLHRLSIERVRAVADITLMLYELLEQVDKAQPTQPIAYMDPICDLLYHIKYMFVGDTMKTELEAIIRRLRPALQMRLRFITRLNVEEIGVDQKAATAQGVTNSATGVTAAGVAAGTTGTTQGVVTPGQGTPGSTTGPQQQTQVSGVANQNVALQQQLQQQMGQGIQTHH
Length1432
PositionTail
OrganismAnopheles funestus (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.109
Instability index42.59
Isoelectric point7.63
Molecular weight163772.84
Publications
PubMed=21129198
PubMed=31157884

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08071
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.48|      16|      17|    1369|    1384|       1
---------------------------------------------------------------------------
 1352- 1368 (20.24/ 9.86)	GVdQ..KAATAQGVTNSAT
 1369- 1384 (26.96/15.33)	GV.T..AAGVAAGTTGTTQ
 1385- 1402 (24.28/13.15)	GV.VtpGQGTPGSTTGPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.28|      13|      17|     254|     269|       2
---------------------------------------------------------------------------
  254-  269 (17.42/14.65)	PYDEELLqpqARLLRF
  274-  286 (25.86/12.44)	PYSRDMV...CSMLNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.36|      11|      16|     723|     735|       3
---------------------------------------------------------------------------
  723-  735 (18.30/14.28)	NDPQssAWCKDLL
  741-  751 (24.05/12.42)	NTPH..AWPQHTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.42|      18|      18|    1115|    1132|       4
---------------------------------------------------------------------------
 1115- 1132 (31.63/20.88)	LYVTCVELLGLPVGPNVV
 1134- 1151 (29.79/19.22)	NSIIDVLVKGYTVVPNAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     198.98|      49|      52|     361|     409|       7
---------------------------------------------------------------------------
  326-  370 (72.93/45.85)	ALN.EHDNDQSHTQ.....WVWL.HLSSQLIYFVLFQFAT....FQNIVNALHEKL
  371-  419 (81.30/52.03)	AVR.NLRRGRDHLM.....WVFLQYISGSIQKHSILNFLPI.LKLYDILYPEKESL
  420-  464 (44.75/25.07)	PVPdNSNPNCTHQMaptciWIHLMK.RAQTENYNINRPIPIaLRLH..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.19|      24|     327|     470|     503|       9
---------------------------------------------------------------------------
  470-  503 (34.82/45.66)	HLAMpSNNPTLFmgseyrfalLCNAYS..TQTDYFS
  798-  823 (41.37/25.19)	HFGM.TVNPPLF.........LCLVFKmiIETDVIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.70|      57|     328|     175|     252|      10
---------------------------------------------------------------------------
   31-  100 (89.12/53.23)	KKTEegYK....KIGTLFGAMTPE.VKEASIRSYLGY...VATVNHQNRVHNYlqvmnrmvalnIIPAKLLCDQLMCS
  184-  248 (84.58/82.55)	KKTD..YQnmhwRVSNLTANFIEEfVSVAQMLSIIGHssmLPIVEHSSYADNL...........IIPWKLDPDTLKLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.53|      14|      15|    1182|    1195|      11
---------------------------------------------------------------------------
 1182- 1195 (25.61/15.10)	LNSKAMKEWTYRQS
 1200- 1213 (23.91/13.66)	FNFKIVKESMLDRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.64|      10|     320|     678|     687|      16
---------------------------------------------------------------------------
  678-  687 (17.84/12.07)	EVQAQLSRYL
  986-  995 (17.80/12.03)	EVPTQLSKTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.28|      10|      17|    1052|    1063|      20
---------------------------------------------------------------------------
 1052- 1063 (15.59/15.65)	NWALTEAYqaYM
 1072- 1081 (20.68/12.61)	NWVPELSY..YI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08071 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTTGTTQGVVTPGQGTPGSTTGPQQQTQVSGVA
1378
1410










Molecular Recognition Features






MoRF SequenceStartStop




NANANA