<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08071

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSAELRIVKLFEEVLEDKNIVPSFDEEEQRKKTEEGYKKIGTLFGAMTPEVKEASIRSYLGYVATVNHQNRVHNYLQVMNRMVALNIIPAKLLCDQLMCSDKLVYKNPCFWIEAFRLIRKVIGGVDYKGVREIMKCCKEKALSFPANVSVNILPQLLELIELIEHIFNRNACLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSSMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDEELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMEYSEKEGTQAQNTASTALNEHDNDQSHTQWVWLHLSSQLIYFVLFQFATFQNIVNALHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKESLPVPDNSNPNCTHQMAPTCIWIHLMKRAQTENYNINRPIPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMVGGGVQSLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYLSEPKPPGNIVSAESEELNRALILTLARSMHITGTGNDPQSSAWCKDLLQNVMLNTPHAWPQHTLYCFPPVLNEFFMQHNIPKESKQLLKKTVDEEYRNWASMTNENDIIAHFGMTVNPPLFLCLVFKMIIETDVISPVAYKILERIGARALSTHLRKMCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIVTIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTTEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPTLPVYFGNVCLRFLPVLDIIVHRFLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWALTEAYQAYMMTKETDNVNWVPELSYYINLVRRMQDTMDGKNIFSGTDWRFNEFPNPPAHALYVTCVELLGLPVGPNVVANSIIDVLVKGYTVVPNAVIHNWTNTIGLIMAALPEAYWSVIYERMQGALNSKAMKEWTYRQSPFEMFNFKIVKESMLDRSYVTVLAIVHSIFHHFGIGQLATVTESLKEKLKPLVHTEYQLIYVCHVVGPFLHRLSIERVRAVADITLMLYELLEQVDKAQPTQPIAYMDPICDLLYHIKYMFVGDTMKTELEAIIRRLRPALQMRLRFITRLNVEEIGVDQKAATAQGVTNSATGVTAAGVAAGTTGTTQGVVTPGQGTPGSTTGPQQQTQVSGVANQNVALQQQLQQQMGQGIQTHH
Length1432
PositionTail
OrganismAnopheles funestus (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.109
Instability index42.59
Isoelectric point7.63
Molecular weight163772.84
Publications
PubMed=21129198
PubMed=31157884

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08071
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.48|      16|      17|    1369|    1384|       1
---------------------------------------------------------------------------
 1352- 1368 (20.24/ 9.86)	GVdQ..KAATAQGVTNSAT
 1369- 1384 (26.96/15.33)	GV.T..AAGVAAGTTGTTQ
 1385- 1402 (24.28/13.15)	GV.VtpGQGTPGSTTGPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.28|      13|      17|     254|     269|       2
---------------------------------------------------------------------------
  254-  269 (17.42/14.65)	PYDEELLqpqARLLRF
  274-  286 (25.86/12.44)	PYSRDMV...CSMLNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.36|      11|      16|     723|     735|       3
---------------------------------------------------------------------------
  723-  735 (18.30/14.28)	NDPQssAWCKDLL
  741-  751 (24.05/12.42)	NTPH..AWPQHTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.42|      18|      18|    1115|    1132|       4
---------------------------------------------------------------------------
 1115- 1132 (31.63/20.88)	LYVTCVELLGLPVGPNVV
 1134- 1151 (29.79/19.22)	NSIIDVLVKGYTVVPNAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     198.98|      49|      52|     361|     409|       7
---------------------------------------------------------------------------
  326-  370 (72.93/45.85)	ALN.EHDNDQSHTQ.....WVWL.HLSSQLIYFVLFQFAT....FQNIVNALHEKL
  371-  419 (81.30/52.03)	AVR.NLRRGRDHLM.....WVFLQYISGSIQKHSILNFLPI.LKLYDILYPEKESL
  420-  464 (44.75/25.07)	PVPdNSNPNCTHQMaptciWIHLMK.RAQTENYNINRPIPIaLRLH..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.19|      24|     327|     470|     503|       9
---------------------------------------------------------------------------
  470-  503 (34.82/45.66)	HLAMpSNNPTLFmgseyrfalLCNAYS..TQTDYFS
  798-  823 (41.37/25.19)	HFGM.TVNPPLF.........LCLVFKmiIETDVIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.70|      57|     328|     175|     252|      10
---------------------------------------------------------------------------
   31-  100 (89.12/53.23)	KKTEegYK....KIGTLFGAMTPE.VKEASIRSYLGY...VATVNHQNRVHNYlqvmnrmvalnIIPAKLLCDQLMCS
  184-  248 (84.58/82.55)	KKTD..YQnmhwRVSNLTANFIEEfVSVAQMLSIIGHssmLPIVEHSSYADNL...........IIPWKLDPDTLKLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.53|      14|      15|    1182|    1195|      11
---------------------------------------------------------------------------
 1182- 1195 (25.61/15.10)	LNSKAMKEWTYRQS
 1200- 1213 (23.91/13.66)	FNFKIVKESMLDRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.64|      10|     320|     678|     687|      16
---------------------------------------------------------------------------
  678-  687 (17.84/12.07)	EVQAQLSRYL
  986-  995 (17.80/12.03)	EVPTQLSKTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.28|      10|      17|    1052|    1063|      20
---------------------------------------------------------------------------
 1052- 1063 (15.59/15.65)	NWALTEAYqaYM
 1072- 1081 (20.68/12.61)	NWVPELSY..YI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08071 with Med23 domain of Kingdom Metazoa
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