<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08060

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSNLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLIPKLHEHYHQGPLQEKSSAGGTGPSSGMGGTNSSGLGLNSGGGGSNPSTIPPPLSSPAGSMHSPAGGNPVGSSMHSQQQQQQQLSPQEEQRLAQKQWNYCTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLHDFVQSERFCRRLAYAVSKKLTQLINQMAESHNINLSSPEPDANGKQTCNDAPDIKLEKQHEKPAKEGTSASAAITQSGDVKPPAKTNPYEMIFTEYMHCSHHRDVVLQLSSILQVITLECPTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPMPDRYEESNEDIRRQLFEAEESIKVRSRHAESRWCIDKWQTAAGNASLKILATLHALDGHCFDRMDSNNSLDSLYSKIFPPFQVQSIKPADSVGSGSGGNGVGSGAGVVTTADGKDAATKQFEYNVEQDSSIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVLTALENDSYNQNLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLEEGGGSQNKSQFTNLVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDSHGICSNAGLGTGPISNKPATGSSPNNGGGLEDDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHAATSVTGLGKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFESTSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAIGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVELQLIGKSSAALMRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSVCSSLKSRPQQEPFHNAYPKIKQALYTPLQPSPSAHTYNPQFMIDIITSPRRGGKIETGWARQLNESASNRYSFVCNAMVAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQAGKGRGETTPEIEAGARLTCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAQHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGTGKRSGLNTPVHPGSTPKSSGDLSHILGTSDLSILGNPDESMLDVSQQNSHLNQENATSLSDFAQHVLRQICSQEWVLERCLQNAEELCQQGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCIPLELSNWLDMVARAAIDVFRVNEFTLNGSSSSGSQDAKQEKVKPSTWLVAPLISKLPCAVQGRILKVSGQVLESTSMFSKHKEGNAGNSSSNNNSHSHGANSNSSVSSNGSTFGSKQSAQLNHQPFLGLVLTCLKHQDEQKEGLLQSLYSQLSQFLQNRDQSLETIGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVLTCDSAGSSTDAKGNKIAIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTGSKKGKTTRKRKPKATPAAQVQPSQPQQPIMPALGPQAGAGPQQMQQMQQQQQQQQQQQQQLQQQQQQSLQQQQHLQQQQQQLHLQQQQQQQQHLQQQQQLQQLQQQQQQLQQQQQQQQQNQMMMQQQQQQQSNIPQQQQALQQQQQQQQLGPQQSQQQVGMTPQQTLQQMQNANMGGMQMGGPMNAMNQQLMQQQYGQANPGQLVGQANLGGMQSGMGGLGAGMGGGMLNQQQQQQQQQQAQQQQQQQQQQPQQQQQPQAAQQVQQAQQVQQAQQQQQQSQGNPNMGFVGNVNPMAQLAQQQQGGGNQQWGGYGSMQQQHQQQQQQQQQQQQQQQQQQQQVQQQQQPQSQAQQQQTPQQAQQAGPQQQGPQQGPQQGVQQGLQSQMFYSGIGQGTMNRFDRPQNANSKQALSNMLRSKLPISAGHPGFMQQQQPQQQQPQRNPQQQFMRGQLRAGIPGNPIVGGPQAGMGPMNPAMAGGTAGLAAGAGGGTVMGTGPGMGAGGMMGAQQGAQGQQAAGGIMGQNAAAMMGTTGGSIMSQSGGSMIQTGMMNPGPNAAMVAQSMGGGGGAGGGGGAGGLGGAGGMAGNSGMGGGGGGGGAGGMGGGGAGGMVTSGGMVTAGMGNAGLGGAAAMGGGQGGMGGNAGGMPNAGGMGNPAMGNPGMGGMQNMQQSGNMQGGAMFQGQNVPYQNVNQNYGPGYGNQGMGQQGGQGGGMMGNFNQMAQQQRNPQAEFLAQQRAAMAGRGQYGQHAPNVTMGSMGVNQGAVPPYPRQGGNPGVGGNMPQNQQQFQQQQQRMRLIMQQHSGMGQAGNAQGMMQNQGQGMGNQTTPNLVAQLRQMPNQNNMMGQQYPHQPPQY
Length2803
PositionKinase
OrganismAnopheles farauti
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.606
Instability index55.05
Isoelectric point6.72
Molecular weight304858.16
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08060
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            15|     628.73|      27|      29|    2512|    2538|       1
---------------------------------------------------------------------------
 1991- 2017 (47.17/11.14)	QQM.Q....QMQQ.....Q..QQ..QQQ.QQQQQLQQQQQQS
 2019- 2046 (39.14/ 7.87)	QQQ.Q....HLQQ.....Q..QQ..QLHlQQQQQQQQHLQQQ
 2047- 2075 (42.66/ 9.30)	QQL.Q....QLQQ.....Q..QQqlQQQ.QQQQQQNQMMMQQ
 2076- 2107 (39.37/ 7.96)	QQQ.QqsniPQQQ.....QalQQ..QQQ.QQQLGPQQS.QQQ
 2188- 2214 (46.38/10.82)	QQA.Q....QQQQ.....Q..QQ..QQP.QQQQQPQAAQQVQ
 2215- 2240 (37.62/ 7.25)	QAQ.Q....VQQA.....Q..QQ..QQQ.SQGNPNMG.FVGN
 2242- 2267 (41.26/ 8.73)	NPM.A....QLAQ.....Q..QQ..GGG.NQQWGGYGSM.QQ
 2268- 2292 (44.67/10.12)	QHQ.......QQQ.....Q..QQ..QQQ.QQQQQQQQQQVQQ
 2293- 2318 (39.69/ 8.09)	QQQ.P....QSQA.....Q..QQ..QTP.QQAQQ.AGPQQQG
 2446- 2472 (42.34/ 9.17)	PGM.G....AGGM.....M..GA..QQG.AQGQQAAGGIMGQ
 2511- 2536 (45.08/10.29)	S.M.G....GGGG.....A..GG..GGG.AGGLGGAGGMAGN
 2537- 2562 (41.59/ 8.87)	SGM.G....GGGG.....G..GG..AGG.MGG.GGAGGMVTS
 2579- 2603 (43.21/ 9.53)	AAM.G....GGQG........GM..GGN.AGGMPNAGGM.GN
 2641- 2665 (42.76/ 9.35)	QNY.G....PGYG.....N..QG..MGQ.QGGQGG..GMMGN
 2733- 2765 (35.79/ 6.50)	QQQfQ....QQQQrmrliM..QQ..HSG.MGQAGNAQGMMQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     309.77|      54|     199|    2131|    2186|       2
---------------------------------------------------------------------------
 2132- 2186 (92.26/35.42)	.PMN.AMNQQLMQQQYGQANPGqlVGQANLGGMQSGM.GGLGAGMGGGMLNQQQQQQQ
 2322- 2372 (69.58/21.94)	GPQQ.GVQQGLQSQMF...YSG..IGQGTMNRFDRPQ.NANSKQALSNMLRSKLPISA
 2373- 2418 (76.19/24.83)	GHPG.FMQQQQPQQQQPQRNP.....Q......QQFMrGQLRAGIPGNPIVGGPQAGM
 2419- 2445 (33.68/ 6.23)	GPMNpAM.........A....G...GTA...GLAAGA.GG.GTVMGTG..........
 2478- 2507 (38.06/ 7.80)	........................MGTT..GGSIMSQ.SG.GSMIQTGMMNPGPNAAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.77|      30|      46|    1914|    1944|       3
---------------------------------------------------------------------------
 1914- 1944 (50.58/31.66)	PLPLPPEEVDPlPDKLKDDMKADTPSSDQSP
 1961- 1990 (55.19/30.70)	PKATPAAQVQP.SQPQQPIMPALGPQAGAGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.88|      16|      66|    2717|    2732|       5
---------------------------------------------------------------------------
 2717- 2732 (33.04/14.02)	PRQGGNPG..VGGNMPQN
 2782- 2799 (22.83/ 6.78)	LRQMPNQNnmMGQQYPHQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08060 with Med12 domain of Kingdom Metazoa
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