<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08058

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFHKARNKDEYLGFVARLILHVREMNTKHKNQQNAAAAAAQQAQQDGSGNSGQQGGGGGGGGGGGAGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGGGNASNLMHSLRPQMQMGGMGGPMQGNRVGMGPGPGGQMGMMGPNQMQGPGGGMVGAMPGQMGVGIGPGGMSGGKIVGMGGQQQMAQLSAMQVNQMQQQQQQQQQGGMVQAQQQQQQQQQQQQQQQGGMVQGQGGPVQQMAVGGPNQMNPMVMGQIQAQLQNQNVMGGQQMGTVGGNMGAGNQMGQMVGANTGMNPQAMGMATNQVLRQQQQQQQQQGMPQVVNPNQVQMGLGPGQMVMQQQTGGTMVGQAGPNQMNAGLPMGGPGVVGPNVGGVMGPGPGQMLGGGGGGGGGGAGGAGGQQQGNFVGMGAGGMVRKPPDMMPGGNVYPGGGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMGAGVAQRSNIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYRSLTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILSNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAVSASLQGSSGSHTLQRTFRPCLEALFGPDIKNLPPPAKQARLVPEDSATAGSAAGGAGSAGTGSGSAAATGTGTAGATTGATVGGSSAGSTVTIATSATASPQEIPHILQGEIARLDQKFKVSLDQCAISGTRTIKLICRLDDKNLPCVPPVAVTIPEDYPFTAPNCSLIEQEYNATPFLILVQKSLTARICKLPGLFTLSHLLDTWEMSVRQACSPNPTIVAPTGTSVLLGM
Length880
PositionTail
OrganismAnopheles farauti
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.02
Grand average of hydropathy-0.418
Instability index50.11
Isoelectric point9.25
Molecular weight89889.08
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08058
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     134.05|      20|      20|     237|     256|       1
---------------------------------------------------------------------------
  170-  189 (30.00/ 6.24)	MQGNRVGMGPGPGGQMGMMG
  237-  256 (38.71/11.35)	MQVNQMQQQQQQQQQGGMVQ
  258-  277 (32.47/ 7.69)	QQQQQQQQQQQQQQQGGMVQ
  424-  443 (32.87/ 7.93)	PGPGQMLGGGGGGGGGGAGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     385.28|      41|      43|     278|     318|       2
---------------------------------------------------------------------------
  135-  194 (50.30/ 9.00)	GPGGPM.....GgQ...MG.G.GGN...AS..........N..LMHSLRPQMQMGG.MG......................GpmqgnrvgmgpgpggqmgmmgpNQMQ
  195-  231 (50.14/ 8.95)	GPGGGMvgampG.Q...MGVGiGPG...GM..........SG...GKIVG.......MG......................G......................QQQM
  278-  318 (83.26/20.64)	GQGGPV.....Q.Q...MAVG.GPN...QM..........NPMVMGQIQAQLQNQNVMG......................G......................QQMG
  325-  364 (64.03/13.85)	GAGNQM.....G.Q...M.VG.ANT...GM..........NPQAMGMATNQVLRQQQQQ......................Q......................QQQG
  395-  450 (45.93/ 7.46)	GQAGP......N.Q...MNAG.LPM...G...........GPGVVG...PNVGG..VMGpgpgqmlggggggggggaggagG......................QQQG
  456-  496 (46.29/ 7.59)	GAGGMV.....R.KppdMMPG.G.....NV..........YPGGGGAVRSVTPN.NFLR......................Q......................SPSP
  497-  549 (45.33/ 7.25)	SVPSPV.....G.P...GAHG.PPShpgQMipspalipspNPH.MGAGVAQRSNIGQSP......................G......................GSLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.27|      19|      19|     697|     715|       3
---------------------------------------------------------------------------
  697-  715 (32.41/12.58)	AGSAAGGAGSAGTGSGSAA
  717-  735 (32.86/12.87)	TGTGTAGATTGATVGGSSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.91|      31|      42|     620|     650|       5
---------------------------------------------------------------------------
  620-  650 (51.01/31.06)	TLHKC.EAALTSQLGSIRETPTNNPLVEAVSA
  664-  695 (50.89/30.97)	TFRPClEALFGPDIKNLPPPAKQARLVPEDSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.60|      21|     253|     109|     131|       7
---------------------------------------------------------------------------
  109-  131 (36.86/18.30)	MPDPINAlqNLASQGTRP.QM.MGQ
  365-  387 (33.74/11.89)	MPQVVNP..NQVQMGLGPgQMvMQQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08058 with Med15 domain of Kingdom Metazoa
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