<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08057

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMIMDNSKTTSKTTLLKLMLLRAWKERWTDCQWGINVKTILTRGVSGDVYNLADAIIQQAVVGSGANMLFLSYLKHSLCAHLISHAAVLNRIAKYEQFDKHHCLIALLDFLKSIVDGVTCRGKQEESILTKATVSLVNWLMQIYECILQTYAETRALQPEEEDVVQRVACVLERIAENPFLLGVLSIGKCDDPELFVALQKRFNSINNLTVSTGYVAQVAQGTGSAKNVTVTDYMRKLMMLEVDLLEMKLFDGGKVEAITYSLQPLIAIEVLLNPMCDTNQYVAQLIGLKRLKGFSSSRLYYELMSACLVSLNNVEGTAKESLLCAFAFIKVPHIVHQIHTKMNGKEQNDETTGTSYSTEVVEAFEMLLQDTQVLDYMDMKCACNVVECLLKEMVKHNLLTETHVSHFGALREPITLGLQKLEANNAQLTLMLKFVFRVESPLVGILKALNTDHSKVQDALLAMLCQVLTGNSLDLVLSVASVEGKFKAFISGLLKCNEYAKQPPGVVELGKAGTTRGALFDVTFMILACIAQSYGSDVILAEGGNSFFEKWVRDFMVERKKTKSPMAMVKQADPMVLEKLIMALKNSNGAGDGSGGLKASTLRWEDICYTIPALLHQVLMAWENEKISPVEIKKMLDALKAHFCSFAVCASSWLCAYMQMVRQDEQLKPMTMVQQLCAALIGPQAEEWQQQDYCKERFGLMGQIIRRMQLELQRMPQINPKLRALFPNNQQQSIVSHLPLEEQFEEAWKGIAERGWLPIETAFLLDTLLQSCGPLWLVEKLIAKLFLCKYIRELNKTMDIIFAIMHLDIERCTIALLSQLVPKMLLNKQQTPEIVDPQSRVLAKLCVYCIIVTMEASASAAASKKRTRGATGQSDVDDIDALCTSAKLRKIELDGMGIGCEGSTGTELTLESALESAVGWDSVTTPPAVTTLKEPLQACLQTLFRTFTQYITTDELSPKVHFIFQFLSLLVESGRDRIMCVLKLVPNGLVQNLLKINATDEMMEGLILRLYDLSTTSGRQFAMSDICLLRNIQLRKESIKL
Length1041
PositionTail
OrganismAnopheles farauti
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy0.105
Instability index38.73
Isoelectric point6.25
Molecular weight116325.07
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08057
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.18|      16|     103|     546|     571|       1
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  556-  571 (28.50/33.92)	MVERKKTKSPMAMVKQ
  660-  675 (29.68/10.99)	MVRQDEQLKPMTMVQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.11|      67|      93|     354|     431|       4
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  354-  428 (90.57/90.35)	TSYStEVVEAFEMLLqdTQVL..DYMDMKCACNVVECLLKEMVKhNLLtetHVSHFgALREPITLGLQKLEANNAQL
  451-  519 (103.54/69.73)	TDHS.KVQDALLAML..CQVLtgNSLDLVLSVASVEGKFKAFIS.GLL...KCNEY.AKQPPGVVELGKAGTTRGAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     230.82|      75|     161|     755|     836|       7
---------------------------------------------------------------------------
  755-  836 (117.68/100.29)	GWLPIETAFLLDTL...LQSCgplwlVEKLIaKLFlCKYIR..ELNKTMDIIFAIMHLDIE..RCTIALLSQLVP....KMLLNKQQTPEIVD
  919- 1004 (113.13/75.25)	GWDSVTTPPAVTTLkepLQAC.....LQTLF.RTF.TQYITtdELSPKVHFIFQFLSLLVEsgRDRIMCVLKLVPnglvQNLLKINATDEMME
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08057 with Med24 domain of Kingdom Metazoa
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