<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08056

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMCVRPSHSLKGKTDLCGIRWRQFVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVAPKPKPKPEPEPSSMFDMSIPGTGNIGPVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELRTEAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIGRWFVHPSSNGERVFGKSSHHASFSFAFFVHGDSTVCASMDIREHPPVRLLTMKHLEEAQAQQPNTTPNAANAASGSSGPNGPASPPSSAVGAGLNGCGSVTPGSPAGGGGAGAVSNGVSSADIATSEPREVILAPFGLAGTLTGQSYKASDPHTQKILDDWSAFYPISNNHGMGDGVDNVVPPIVEILVGKVKMRYPSRYVLVADMDDWTSSSDPARSSATGSSSSSSSSSNQTTSPVTTAASIAASVMSRINNAGGAINTSQASCSSSFSAAASSNQPTAAGSTGPNRPKDASSSSSSSGLPSSPTGGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHAVAPTQPSSTGPGRSTTTTNTTTTNTTTTTSGSGGGVTIKTEPKDTSSSSSSSSSSSNTTNIATSNNTGGGDENSSGAANGVDANGNSSVWEISDPTAKVSCCCIKCCKRPPSSSSSSTTSSSTSAAASGRSQQQQQTIGAAAATASSSCSAVTTVGSSIIYTSISSPGATGGGGGGVSGGIGSIHHYPKSSSSSFPITYPGSGRGDKSSYQHYHHAGSQSGKDPHHHHHQHHHHHHHHHHHRPARIAFHKRPPQEPLFRPGSNLISLSAAAAALAAASAASNVPAASSPGAVSSGDSAADSLELADSCLRSNQSCAANSTSGGSNATGTAAPGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGSTGNGGGGGGGGGGATGTGSDTQQQSQSGSTMGNSSSSSSSSSAGSNSSSTSNTHKTTGGPLSAGLGGGLKVRSESSLGAGGGSGGGVPMTPSIHSVYSSAHQTAVANNLASKRESILQMLQSLKRPLLFCKDYETMQSDDIPSTSQLLYDYTCVDAWMNHPVKRMRLAAEENRLVKKIRNLDLYANEHSRTLSSVGTSGYGGPNTSNGLLLKGLTAGSEPSDALGDALGNTVGGAACDNGSTGSNGNVPPLIGQIKMEIGCDSNASGHQQPGGGANVPAAVDGTTGSANGTPDRNGMGGGELLGEHEIKKEKDDKGAGAYSLLTDQGLQPSIDDLNQIFDDGGTFNDDPDLHNTPPGSNKSSGGGSGGFLDESKRFPGSNNHHHSVNSGMHSPKELSLMFPTPPSHDPHPNSSPSGGGCLSDGGIAIDTLVDLQMSLSSSGVGTAGGAGGVGTGGGGGGGGAGAGGGVGSSGVPVPIVPNLGSPQEEPIDDWSFVFLPPPVCPYVGSSKYAPLPTLPSQQLLPPVPPGLPPATLVYKSTRQKQKEQAAAEREKQKLREQAEREREREREQQQQQQDPTQPSTQSDSNTSQDASQVRTAPVSSLNAPPGLGLGLLPMLKQELTGGGGGGLSVPQPLSTPNSLLGGLNSLNGSLNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIMGGGAGMLSPSPAGAGGGGGTSGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGPAGSPNPMGSHFRRNTPLLPPPPYDVAIASPANSVATPSSYHSKAFPLDGVDGGSGGPGSNRGPMTPSSTGALGGSSTVHQPLSSAGAGGCVGGVAGMNGTGALGSRSGSIETNALLVNVLLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLPLPGTNWMDSVTGPADGGSGEVGKIGAKGKAGALAHLGLGGSAFGGMIGSPAIGGGSSSNDKTATINTDSLQNGYLDEDPIDCQCGFSAVVNRRLAHRAGLFFEDEMEITSMAEDPAVHKKSSLFEFHNGTARAIKMDESSGSGGVGSGASSSTATTSANDCLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRIRGSLFSRGGAGAGPGESGAAVHLLEYVDANDVISMALEQGRLQAINESKQEHEQSSSSASSSSSSSVVIASGGGGVLVKGGTLRGSMNVHRWAFLRAGGPKSNQDIKRIMMSMQPLLQDAFHKRCTTRLWDAPYTILGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNQDEWFLNMGVDQHQQQQRKNGATSAGAGACQSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTASSSASGGSSLRGDGSGGGGGSGGSSSASSSLSGGSSSMGQPGSGAGMGQNRGDVGGPGQSPMPPPPPSTPDPSQPGDKAPNTPKFDHDAENRDQLNTSSASPADGMRIDDDGKDPPHIVLYLVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPESIRSNISVQIVSLESILELGRSRNRLRLSDHMRYLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSAADLDLGEDLNMVILETEDDDDINMMDMDMFNCWDDLKNQQPLPHSRPGSPSQFEGNQQSPGEGGSKGTGSRDGYGSQDSEEVGVVLQQPLAIGYLVSTAPTGRMPDWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSSITADVLRYVLEGYNMLSWLAMDSNTHDRLSCLPIHVQVLLQLYHMTAALA
Length3078
PositionMiddle
OrganismAnopheles farauti
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.438
Instability index56.65
Isoelectric point6.31
Molecular weight319290.34
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08056
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|    1635.46|     204|     205|     236|     439|       1
---------------------------------------------------------------------------
  194-  383 (281.54/65.74)	.G...DS...TVCASMDIREHPPVrlLT............MKHLEEA...........QAQQP....NTTPNAANA...............................ASGS..SGPNGPASP.PS.SA.VG.AGLNGC.......GSVTP....GSPAGG......G.GA..GAVSNGV.........SSADIATS.....E.P...R..EVIL...APF........GLA.GT.................LT..GQSYKA..SD..P.................HTQKILDD..WSAFYPISNNHG..MGD....GVDN....VVPPIVEI...LV..GKVKMRYPSRYVLVADMDDWT.SSSD.PARSSA
  384-  545 (194.53/42.99)	TG...SS...SSSSSSSNQTTSPV..TTA.ASIAAS...VMSRINNAG.GAINT...SQASCS....SSFSAAASS...........................nqptAAGS..TGPNRPKDA.SS.SS.SS.SGL..............P....SSPTGG......TlRQ..RNHHKSM.........MTPPLTVP.....EsP...S..NDLG...NPL........SMS.SA.................LI..NKSPAV............................ILPErvWQ..............D....CIMH....AVAP.............................TQP.SSTG.PGRSTT
  546-  630 (97.14/17.52)	T...............TNTTTTNT..TTT.T.......................................................................................................................................S.GS..G...GGV.........T...IKT......E.P...K..D......................T.................SS..SSSSSS..SS..S.................NTTNI..........ATSNNTG..GGDenssGAAN....GVDANGNS...SV.....................WE.ISDP.TAKVSC
  631-  817 (181.71/39.63)	CCikcCK...RPPSSSSSSTTSS...STS.A..AAS.....GRSQQQQ.QTIGA...AAATAS....SSCSA.....................................................vTT.VG.SSIIYT.......SISSP....G..ATG......G.GG..GGVSGGIgsihhypksSSSSFPIT.....Y.PgsgRgdKSSY...QHY........HHA.G......................SQSGK....D..P.................HHHH..HQ..HHHHHHHHHHHR..PAR....IAFH....KRPP.QEP...LFrpGS...NLISLSAAAAALAAAS.AASNvPAASS.
  818- 1004 (180.21/39.24)	PG...AV...SSGDSAADS........................LELAD.SCLRS...NQ.SCA....ANSTSGGSN..........................atgtaAPGS..TTPYG..GP.PS.Y..........C.rnpmsiGDSHPlpseGSPASA......A.PS..PMQPSSV.........SQPTSVPS.....G.D...Q..LITM...SPH........PPA.SN..................N..PRSVQP..GT..PcldhldkntpaptptdqHDSKSINA...SPYHTPSHPGG..GGG....STGN............................GGGGGGGGGGATgTGSD.TQQQSQ
 1005- 1136 (116.60/22.61)	SG...STmgnSSSSSSS...SS......A.GSNSSS...TSNTHKTTG.GPL..........................................................S..AGLGGGLKV.RSeSS.LG.AG.GGS.......GGGVP....MTPSIH......S.VY..SSAHQTA.........VANNLASK...........R..ESIL...QML.......qSLKrPL.................LF..CKDYETmqSDdiP.................STSQLLYD..YTC.........................................................VDAWM............
 1137- 1365 (164.79/35.21)	.................NH...PV..KR..MRLAAEenrLVKKIRNLD.LYANE...HSRTLSsvgtSGYGGPNTSnglllkgltagsepsdalgdalgntvggaacDNGS..TGSNGNVPP.LI.GQ.IK.MEI.GC.......DSNAS....GHQQPG......G.GAnvPAAVDGT.........TGS..ANG.....T.P...D..RNGM...GGG........ELL.GEheikkekddkgagayslLT..DQGLQP..SI..D.................DLNQIFDD..GGTFNDDPDLHN..TPP....GSNK....SSGGGSGG...FL..DESK.RFPG..............SNN.HHHSVN
 1366- 1510 (158.68/33.61)	SG...MH...SPKELSLMFPTPPS..HDPhPNSSPS...GGGCLSDGG.IAIDTlvdLQMSLS....SS...........................................................gVGtAG..GA.......GGVGT....GGGGGG......G.GA..GA.GGGV.........GSSGVPV.........................................................................................................PIVPNLGspQEE....PIDDwsfvFLPPPVCP...YV..GSSK..YAPLPTLPS..QQLL.PPVP.PGLPPA
 1556- 1647 (55.87/ 6.72)	TQ...PS...TQSDSNTSQDASQV..RTA....PVS...SLNAPPGLGlGLLPM...LKQELT....GGGGGGLSV........................................................................................................................pqplsT.P......NSLL...GGLnslngslnHPY.SN.................PP..SQGAQ...SQ..P.................H......................................................................................
 1656- 1818 (140.24/28.79)	...........................................................................................................LPGGimGGGAGMLSPsPA.GA.GG.GGGTSG.......GLFHP....G..MGGipvplrQ.GM..SPISPAT.........PGGSMRVP.....T.P...Q.gSCPLpypSPL........GPA.GS.................PNpmGSHFRR..NT..P.................LLPPPPYD..VAIASP.ANSVA..TPS....SYHS....KAFPLDGVdggSG..GPGSNRGPMTPSSTGALGGSS.TVHQ.PLSSAG
 2417- 2505 (64.16/ 8.89)	..............................................................A....SSSASGGSS.............................lrGDGS..GGGGG..............SGGSSSassslsgGSSSM....GQPGSG......A.GM..GQNRGDV.........GGPG..................QSPM...PPP........PP..ST.................PD..PS..QP..GDkaP.................NTPKFDHD...............................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     358.14|      91|      95|    1942|    2035|       2
---------------------------------------------------------------------------
 1831- 1934 (109.74/64.24)	GTGALGSRSGSIETNAlLVNVllyDTALNIFRDHNFKSCTlcvCnaGA....KCVGNIRGAD..SGLYLplpgTNWMDsVTGPADGGSgeVGK...IGA.............KGKAGALAHLGLGG
 1942- 2035 (153.25/100.41)	GSPAIGGGSSSNDKTA.TINT...DSLQNGYLDEDPIDCQ...C..GF....SAVVNRRLAH.RAGLFF....EDEME.ITSMAEDPA..VHKkssLFEF...........HNGTARAIKMDESSG
 2040- 2132 (95.15/54.39)	GS.....GASSSTATT.SAN....DCLPLTLKVMDLLREQ...C..SVvqssSNSIHRAVNRiRGSLFS....RGGAG.AGPGESGAA..VH....LLEYvdandvismalEQGRLQAI.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     195.12|      55|    2208|      13|      67|       3
---------------------------------------------------------------------------
   13-   67 (104.33/59.20)	TDLCGIRWRQF.VLGERPNAAGDPLDDP.VVRSYSK...CLAVDILCVWRRVAPKPKPKP
 2222- 2281 (90.79/50.46)	TILGPLTWRQFhRLAGRGTGQCEPQPIPsLIVGYEKdwlSLAPYALHYWDKLLLEPYSYP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08056 with Med13 domain of Kingdom Metazoa
Unable to open file!