<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08055

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPQPLEQGAVTSFIPTGQEMAQRQNLIPLGRLIDFIIQRTYHELTVLAELLPRKTDMDRKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMGFLDKQSMLFIDTADMLSRVARETLVHARLPNFHIPAAVEILTTGSYSRLPSVIRDRIVPPDPITPAEKRQTLQRLNQVIQHRLVTGSLLPQLRKFRIENGRVTFKVDHEFEVSLTVMGDAPTVPWRLLDIDFLVEDKETGDGKALVHPLQVNYIHQLIQGRIVDCTDALAEVYTCLHYFCQSLQLEVLYTQTLRLIRDRLDDHIHVDEYVVGSRLTVSYWRELTNKDPKSELGYRLTIQTDPNDAAKQLAILHMPSIGNKEADIADRAVRSDLLSMERLLVHTVYVRSLARLNDVKTELQLFLKDVDYLIQGTPAILTVPVLNPCLRAEYIYITVDTHTGMLRCHVPKHLDCPIMPEMQHALNNDWSKLQHLISELRYWITQRRCEKTLQHLPAATQDRLPLIYAQNHPIARMGPHKVFIQLYRHANVILIVELKEKTSCPNEMTYTFYLVLVKPSSVEEGQSQEASSSTGPQSQSSATGGQPSGSEPTAAMPKMYLRVLSMIEFDTFVATHGPGTHIDDPVSSSGSNGAPGSSKRKASSLDNTLPGMGPPMKQQKTIYPAYFIPELAHVVAMCDEKLPFVTLAKEFTMRKIPHGGLQVEANATSLVLKLLTLPQPKPPQVPPTAAPSQQQQQPAGGATAPGAAAGSDPKAPAPAAPASAATNEPKTVHVPPIDKQVWNALLKRLLSVSVRAQVNKSNQTRLWTMELVFYGSPLPSLHHKEQGMRRAVYLQYEMQPVESVSKVVDQLLSDWSKIVYLYTLVHEFREQFNNEKYNLSSMVAIKSYSYTNLLLAYGPNREVSVNICWDTEAKEFRLVFTGGNSAINAHSMMRDQLQAHLNHNYSLAQIVHMLHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRFRGGGLCTIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVFRRRSQSEDDNPPSPVTLEDPSGGTGGGGGVGGVAVGGGGAGTGGGGNNGGGVGGSNTFLGGGGSGMRGPQSPRDPGLRFAAPLTPPTTSNPHTPASPHGGGGGGGGGSGGGGGGGGGGGGGGGGGAGGAGGGPGSGQGGQGQQPGSQMNNFNMTSPPASHMPHPSPSGGLMPSSPLNAQPSPMAAHSPGPSSLPYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYASRVLPARSWAGAIPTTLTYEALDTLCRATPHPQKEVPGPELSPLERFLGSVFMRRQLQRIIHQEESLMAITSNEPGVVVFKADCLQYQVFLNPNHMQSLHLKVDQLQMGPMMDGKPPYQWAAQDLQILEQFFDQRVAAPPYRPAVMTSFTRMLNLPAKVLKDFIQIMRLDLMPELGQGNKWNVQFVLRVPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMEWKDAVTMLLPMVYDMNMNHTTLAERREPMPPQLTSAVSAHLRRFSESSMLLPDECSLFPAVHDLLVTLTLPNEPHAPNQMQMQLGGVMQPGGGPGGPGGPGGPMGGQIGGPASQVVPQVGSSPGPMMHSPMQQMGGVGQQPGGYGGMVGGGPQGGGPGGGSGPGGPN
Length1687
PositionTail
OrganismAnopheles farauti
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.06
Grand average of hydropathy-0.270
Instability index53.26
Isoelectric point8.51
Molecular weight182970.39
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08055
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     175.76|      15|      15|    1149|    1163|       1
---------------------------------------------------------------------------
 1072- 1086 (28.03/ 7.69)	GGTGGGGGVGG.VAV.G
 1087- 1099 (26.11/ 6.68)	GGGAGTG..GG.GNN.G
 1150- 1165 (32.34/ 9.96)	GGGGGGGGSGG.GGGgG
 1612- 1625 (33.26/10.44)	GGPGGPGG.PG.GPM.G
 1656- 1671 (26.56/ 6.92)	GVGQQPGGYGGmVGG.G
 1672- 1684 (29.46/ 8.44)	PQGGGPG..GG.SGP.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     177.97|      26|      27|    1183|    1208|       2
---------------------------------------------------------------------------
  723-  756 (29.36/ 7.88)	TAAPSQQQQQ.PaggatapgaaaGSDPK...AP.APA......A.....P
 1111- 1144 (32.63/ 9.63)	GGGSGMRGPQsP...........RDPGLRFAAPlTPPttsnphT.....P
 1184- 1212 (47.17/17.42)	GSGQGGQGQQ.P...........GSQMNNFNMT.SPP......A..shmP
 1213- 1240 (35.38/11.11)	HPSPSG.GLM.P...........SSPLN..AQP.SPM......AahspgP
 1241- 1266 (33.43/10.06)	SSLPYMQSHT.D...........GSP...FAAL.SPA......A..snwP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.82|      15|      17|    1278|    1292|       3
---------------------------------------------------------------------------
 1278- 1292 (29.51/18.50)	PGQSPEHKVQTSHHY
 1298- 1312 (27.31/16.44)	PARSWAGAIPTTLTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.34|      26|      48|    1528|    1553|       7
---------------------------------------------------------------------------
 1528- 1553 (49.99/27.87)	LLPMVYDMNMNHTTLAERREP..MPPQL
 1577- 1604 (43.34/23.14)	LFPAVHDLLVTLTLPNEPHAPnqMQMQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.05|      34|      49|    1432|    1466|       9
---------------------------------------------------------------------------
 1386- 1403 (27.57/11.96)	.....PNHMQS....LHL..KV.......DQLQMGP
 1432- 1466 (61.02/40.48)	PP.YRPAVMTSFTRMLNLPAKVLKdFIQIMRLDLMP
 1483- 1514 (49.46/27.62)	PPsATPIVPVGTTTILSHRQKILF.FIQITRV...P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.69|      57|     566|     760|     832|      10
---------------------------------------------------------------------------
  760-  832 (82.05/86.65)	ATNEP.KTVHVPPIdkqvwNALlKRLL.SVSVRAQVNKsnqtrlwtmeLVFYGSPLPSLHHKEQG..MRRAVYLQYE
 1321- 1381 (89.64/55.97)	ATPHPqKEVPGPEL.....SPL.ERFLgSVFMRRQLQR..........IIHQEESLMAITSNEPGvvVFKADCLQYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.79|      52|     566|     287|     343|      11
---------------------------------------------------------------------------
  287-  343 (79.75/70.84)	LYTqtlrLIRDrLDDHIHVDEYVVGSRLTV...SYWRELTNKDPKSELGYRLTIQTDPND
  856-  910 (84.04/59.25)	LYT....LVHE.FREQFNNEKYNLSSMVAIksySYTNLLLAYGPNREVSVNICWDTEAKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.69|      14|     460|    1170|    1183|      12
---------------------------------------------------------------------------
 1170- 1183 (26.96/10.15)	GGGGGGAGGAGGGP
 1632- 1645 (24.73/ 8.67)	ASQVVPQVGSSPGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08055 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EEGQSQEASSSTGPQSQSSATGGQPSGSEPTA
2) FRRRSQSEDDNPPSPVTLEDPSGGTGGGGGVGGVAVGGGGAGTGGGGNNGGGVGGSNTFLGGGGSGMRGPQSPRDPGLRFAAPLTPPTTSNPHTPASPHGGGGGGGGGSGGGGGGGGGGGGGGGGGAGGAGGGPGSGQGGQGQQPGSQMNNFNMTSPPASHMPHPSPSGGLMPSSPLNAQPSPMAAHSPGPSSLPYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYA
3) LKLLTLPQPKPPQVPPTAAPSQQQQQPAGGATAPGAAAGSDPKAPAPAAPASAATNEPKTVH
4) LTLPNEPHAPNQMQMQLGGVMQPGGGPGGPGGPGGPMGGQIGGPASQVVPQVGSSPGPMMHSPMQQMGGVGQQPGGYGGMVGGGPQGGGPGGGSGPGGPN
5) PGTHIDDPVSSSGSNGAPGSSKRKASSLDNTLPGMGPPM
558
1050
707
1588
613
589
1293
768
1687
651










Molecular Recognition Features






MoRF SequenceStartStop




NANANA