<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08051

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSAEPRIVKLFEEVLEDKNIVPSFDEEEQRKKTEEGYKKIGTLFGAMTPEVKEASIRSYLGYVASVNHQNRVHNYLQVMNRMVALNIIPAKLLCDQLMCSDKLVYKNPCFWIEAFQLIRKVIGGVDYKGVREIMKCCKEKALSFPANVSVNILPQLLELVELIEHIFNRNACLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSSMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDEELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMEYSEKEGTQGQNTSTTGGMNEHDSDQSHTQWIWLHLSSQLIYFVLFQFATFQNIVNTLHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKEPLPVPDYNNPYCTHQMAPTCIWIHLMKRAQTENYNINRPIPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMVSGGVQQLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYVSEPKPPGNIVSGESEELNRALILTLARSMHITGTGNDPQSSAWCKELLQNIMLNTPHAWPQHTLFCFPPVLNEFFIQHNIPKESKQLLKKTVDEEYRNWASMTNENDIIAHFGMTVNPPLFLCLVFKMIIETDGISPVAYKILERIGARALSTHLRKMCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIVTIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTTEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPTLPVYFGNVCLRFLPVLDIIVHRYLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWAVTEAYQAYMMTKESDNVNWVPELSYYVNLVRRMQDTMDGKNIFSGTDWRFNEFPNPPAHALYVTCVELLGLPVGPSVVANSIIDVLVKGYTVVPNGVVHSWTNTIGLIMAALPEAYWSVIYERMQEALNSKPMKEWTYRQSPFEMFNFKVVKEAMLDRSYVTVLAIVHSIFHHFGIGQLATITESIKEKLKPLVHTEYQLIYLCHVVGPFLNRLSTERARAVSDITLMLYELLEQVDKAQPTQPLRYMDPICDLLYHIKYMFVGDTMKTELEAIIRRLRPALQMRLRFITRLNVEEIGVDQNAAGVQGGNPANSAAGASATGAAASGPGAQGIAAPGQGGNVSTGGAGPQQTQVGGSGVPNANVALQQQQMGQGMQTHH
Length1434
PositionTail
OrganismAnopheles farauti
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.133
Instability index42.72
Isoelectric point7.33
Molecular weight163499.24
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08051
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.32|      16|      17|     254|     269|       1
---------------------------------------------------------------------------
  237-  249 (22.36/13.01)	PWK...LDPDTLKLSL
  254-  269 (27.70/18.11)	PYDEELLQPQARLLRF
  274-  286 (24.27/14.84)	PYSRDMV...CSMLNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     470.36|     149|     327|      59|     236|       3
---------------------------------------------------------------------------
   59-  236 (220.40/240.13)	YLGYVASVNHQNRVHNYLQVMnRMVALnIIPAKllcDQLMCSDklvYKNP.........CFWIeafQLIRKViGGVDYKGVREI...MKCCKE..KALSFPANVSVnilpqllelveliehIF....NRNACLLPAYfiINEIKKTDY..QNMHWRVSNLTANFIEEFV..SVAQMLSIIG..HSSMLPIVEHSSYA.DNLII
  328-  384 (33.53/ 7.81)	...........................................................................................................................................MNE.HDSDQ..SHTQWIWLHLSSQLI.YFVlfQFATFQNIVNtlHEK.LAVRNLRRGR.DHLM.
  387-  548 (216.44/161.52)	FLQYISGSIQKHSILNFLPIL.KLYDI.LYPEK...EPLPVPD...YNNPycthqmaptCIWI...HLMKRA.QTENYNINRPIpiaLRLHFEylQHLAMPSNNPT...............LFmgseYRFALLCNAY.....STQTDYfsRPMQALIDTILGNSKN.....PQANMVS..G..GVQQLPTAPLSMRVlDSLTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.97|      11|      15|     724|     736|       4
---------------------------------------------------------------------------
  724-  736 (17.99/16.28)	NDPQssAWCKELL
  742-  752 (23.98/14.35)	NTPH..AWPQHTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.51|      47|     306|     989|    1039|       5
---------------------------------------------------------------------------
  989- 1039 (77.57/61.56)	PTQLSKTLDVILDHLGSL.YKF.HDRPITYLYNTLhyyeRKLRDRPQLKKRLV
 1296- 1344 (78.94/51.43)	PTQPLRYMDPICDLLYHIkYMFvGDTMKTELEAII....RRLRPALQMRLRFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.72|      53|     157|     755|     814|       8
---------------------------------------------------------------------------
  755-  814 (83.05/68.36)	FPPVLNEfFIQHNIPKESKQllkKTVDEEYRNWASMTNE....NDIIAHFGMtvnPPLF..LCLVF
  916-  974 (87.66/53.49)	FRNRVQE.FITINSPEHWKQ...NNWHERHLAFHQKFPEkfapDESVSHPTL...PVYFgnVCLRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.97|      12|      17|    1125|    1136|      13
---------------------------------------------------------------------------
 1125- 1136 (21.49/12.52)	GLPVGPSVVANS
 1144- 1155 (22.48/13.44)	GYTVVPNGVVHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.74|      26|     573|     624|     666|      14
---------------------------------------------------------------------------
  624-  649 (47.62/21.61)	LEMFSYRMHH...IHSHYRVQLLTHLHSL
 1198- 1225 (35.17/11.57)	FEMFNFKVVKeamLDRSY.VTVLAIVHSI
 1244- 1260 (10.95/19.56)	......KLKP..lVHTEYQLIYLCH....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.18|      20|      29|    1353|    1372|      15
---------------------------------------------------------------------------
 1353- 1372 (36.74/20.79)	GVDQNAAGVQGGNPANSAAG
 1384- 1403 (37.44/21.31)	GAQGIAAPGQGGNVSTGGAG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08051 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DQNAAGVQGGNPANSAAGASATGAAASGPGAQGIAAPGQGGNVSTGGAGPQQTQVGGSGVPNANVALQQQQMGQGMQTHH
1355
1434










Molecular Recognition Features






MoRF SequenceStartStop




NANANA