<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08042

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSSGTAAVGGGSGTLPALLMANGGSGGVAGTAGKGIGKPDMKPTGSGGPSGTGGSTGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFPEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSAATHYPDIQSQLAKAPLGLVQKRRGGHPMRLTYFVAPYELLDLSTRTMNALSAERIASERIGCSVAVVLEASSANKLQIQPLVVVSGVGATAQPVYTPIEKHNSTSLPATFVLRLSKPMPINSAMMRAIRGIVSGTGAAGGGGEGGENGPQGSSTSSSLLALIANHASGGSVKDLAKGLLVSLPDQYHCYYLTDNPALRGVMVSSIPFTEPQHVPKILTYLRQQVVFNQLLASCIRTNAPPAAAVTGAAVGGGAAATGGTVSSASGVAATTGRPSALQQLLDGGAVHHHENGLHGGLLVFEVSALSCQYITVSLMHPYEESLATVEFDLANIANIAVRIYCGEGEATDQHTLDRISCVLQRCMSIPVTLRALIKHWEEEHEQKCKPNVLGTIVPSTNGGGPGGGGGGTGPDGSGSGGGAGPADDTPMNGFNLSSLAGGGTGTTGPASSGDGAGAGTPGPNSTPGSASTNGMNGAGVDTAGGLDFCDMLTERNGGREPPEPLAGGVAKKRRMEDFCKSPKSDSNLSVGGGGGCGVGVVAVGEGTEMSGTSTTVTAAAAGRDGLAVTVGGRSEQQQQQQQQQRTQQPPVGATEEDTDGRAAIPAPAGIVDGKGSSLGGTTTTTTATTATSATSNTSTTAATGADVVLLHHPDAAADHHHKPVQSSSSSSLSSLSSNSSSATPLGFTGATVSSSGDQPERVPSAGTLLLESLEFSPTPALNDRPTTTTTTASVKRRRSSSSSSSSSSSSSSSSSSSSSSSSGASDAELDQEMESVDLVEAEMSSFFAETACTPPVKVAGPSGKPLQKVLSPGIEKPAGLEIIPLTTTTTPPSTPSPNMPGTPGGGFPATSVTITPLATPQSSTASSALPSSGSKKPSTSSTGSGHRNREPGTERSSSGKSEKKKKRKLDEGGSSGGGGHLAMGPPNKLPFKSGESSPHRSGLGSSSSSGSSSSSSSSSSSSKSSPKHSSPVHHSHSPKHGGASALGFHSPKHGSPSVSPKHPMHAGGGSSTGGGKPSMSALKSAAASGSSPSSKSSDPSGVGGGGGGGVGGGGGGMNTSTTGSSSKERDKDRSEKKALQFPGSNSSTSNSGSSSSSSSNSANNSTSNAGSRSKASGLKLKQLDLTSGSSMTISMAGDTGGSGSPVVVSPMIDLTGTSSAGQQGSLSGSSTTTTTASSMLQALQAAKNRKAPSSAGGGNGSGGGGLGGSLSAVIDKLKSAQSVDDDGGAVLVLPEMTITQQTTSSSSSSSNSGSVNIGSFGSLGGGTLKDTGKGPSGGLLTSAVGGSGGTLANCVPSSAGIGAASTQPSSMTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSNKSSSSSSKSGGGSNKSGLKSGVSSGPASSKQQQQQQQQNHTTSFSGAFPSSTKSPHYTSSSSGTTKAPFQKSNSFGSLSGSGSSGLKASKVSSPKSASNPASSSSSSSSSSYSSSSSKSSKSSKSSSASSLAGAMLAGGGGGGSGAVGGSGPGSGSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNSVGGSGTGSSGPTSGLNDSSDGGSGSKSAQKDGSVRKQKPNTSSPSPQVSAGGVGSSATLRQQFGTSSPSGDASARLLSDLLGAAAAKGGSKGPPGAGAGTGGMSSVDGTGASGALHPLLPNIVQKMFGSDGTLQSKSNSSDGSMFPSAGRASPGMLSGGGSSSRDGFRSGSAPGTPTATGSMVLPPFPSPISGSASNDADAGALMRPPSRPSSTISNHSHSSQDGTGGNGNDGTSSSTPSGVNTMAAMMLMNAMSGAGGQSSAAGTIPLDGGSGNTNTTTTTTQQLMMAALAAKTGAGVLPTTANSLLNNHHLHHHAQNLLGNLPSPASVSVHIVKSPAPSPLPFTSPHSNASSGHGSGGAGGGSVGPGTGVPGLDDDLMDEALIGIGSK
Length2185
PositionMiddle
OrganismAnopheles farauti
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.349
Instability index53.63
Isoelectric point9.09
Molecular weight215465.13
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08042
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|    1516.26|     204|     205|     915|    1118|       1
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  660-  890 (172.34/24.33)	PDGSGS.GGGAGPADDTPMngfnlSSLAGG........................GTGTTGPASSGdgagagtpgpnstpGSASTNGMNGAGVD...TAG...................G........LDFC..DMLTER..nggrePPEPLAGGVAKKRRMEDFCKSPKSDSNLSVGGG.......GGCGVGVVAVGEGTEMSGTStTVTAA...AAG......RDGLAVTVGGR.SEqqqqqQQQQRTQQPpvgateedtdgraAIPAPAGIvdgkgsS.LGGTTTTTTATTA.TSatSN..TST..TAAT.....G.
  891- 1093 (290.32/47.02)	.ADVVL...LHHPDAAADH.....HHKPVQ.....................sssSSSLSSLSSNS..............SSATPLGFTGATVS...SSG..DQP.ER.......VPSAGTL..LLESLEFSPTPALNDR.......PTTTTTTASVKRRRSSSSSSSSSSSSSSSSSSS.......SSSSSGASDAELDQEMESVD.LVEAE...MSSFFAE.TACTPPVKVAGP.SG.....KPLQKVLSP.............GIEKPAGL......E.IIPLTTTTTPPST.PS..PN..MPG..TPGG.....GF
 1094- 1255 (208.03/31.19)	PATSVTITPLATPQSSTAS.....SALPSS.....................gskKPSTSSTGSGH..............RNREP....GTERS...SSG..KSE.KKkkrkldeGGSSGG....GGHLAMGPPNKL..........PFKSGESSP...HRSGLGSSSSSGSSSSSSSSS.......SSSKS..SP....KH....................................S.....SPVHHSHSP................KHGGA......S.ALGFHSPKHGSPS.VS..PK..HPM..HAGG.....G.
 1256- 1390 (166.77/23.26)	SSTGGGKPSMSALKSAAAS.....GSSPSS.......................kSSDPSGVGGGG..............GGGVGGGGGGMNTSttgSSS..KER.DK.......DRSEK......KALQF................PGSNSSTSN...SGSSSSSSSNSANNSTSNAGS.......RS................................................................................KASGL......K.LKQLDLTS..GSS.MT..IS..MAG..DTGG....sGS
 1391- 1523 (100.97/10.60)	P...VVVSPM.IDLTGTSS.....AGQQGS.............lsgsstttttaSSMLQALQAAK..............NRKAPSSAGGGNGS...GGG..G..............LGGSLsaVIDKLK..SAQSVDDDggavlvlPEMTIT.....QQTTSSSSSSSNSGSVNIGSFG.......S...................................lGGGTLKDTGKGP.SG.................................................................................
 1608- 1776 (184.02/26.58)	...S........NKSGLKS...gvSSGPAS............skqqqqqqqqnhTTSFSG.AFPS..............STKSP.HYTS...S...SSGttKAPfQK.......SNSFG.......SLSGSGSSGLKAS.......KVSSPKSASNPASSSSSSSSSSYSSSSSKSSKS.......SKSSSASSLA.......GAM.LAGGG...........GGGSGAVGGSGPgSG.....SALVNPIS...............IMKMLGY......................PT..GS..MGN..ME.......GF
 1777- 1962 (182.96/26.37)	.AKSLD.TKFQIPK..............................................LSARS..............NSVGGSG.TGSSGP...TSG..LND.SS.......DGGSGS.....KS......................AQKDGSVRKQKPNTSSPSPQVSAGGVGSSAtlrqqfgTSSPSGDASARLLSDLLGAA.AAKGGskgPPGAGAG.TGGMSSVDGTGA.SG......ALHPLLPN.............IVQKMFGS......DgTLQSKSNSSDGSMfPS..AGraSPGmlSGGGsssrdGF
 1963- 2161 (210.85/31.74)	RSGSAPGTPTATG.....S.....MVLPPFpspisgsasndadagalmrppsrpSSTISNHSHSS..............QDGT..GGNGNDGT...SS...STP.SG.......VNTMAAM..ML.....M..NAMSGA.......GGQSSAAGTIPLDGGSGNTNTTTTTTQQLMMAA.......LAAKTGA..GVLPTTANS...LLNNH...HLHHHAQ.NLLG...NLPSP.AS.....VSVHIVKSP.............A...PSPL..........PFTSPHSNASS..G..HG..SGG..AGGG.....SV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.53|      20|     600|      39|      58|       2
---------------------------------------------------------------------------
   39-   58 (40.86/16.69)	KPD.....MKPTGSGGPSGTGGSTG
  383-  399 (26.54/ 6.87)	........VSGTGAAGGGGEGGENG
  635-  659 (36.12/13.44)	KPNvlgtiVPSTNGGGPGGGGGGTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     397.97|     132|     264|     216|     361|       3
---------------------------------------------------------------------------
  216-  361 (196.87/134.01)	LASIYQLNAEKKIKV.NAFVALQALET..DLHTLYTLSAATHYPDIQSQLAKAplGLVQKRRGG.HPMRLTYFVAPYELLDLSTRTMNALsAERIASerigcsvavvLEASSANKLQIqPLVVVSGVG.ATAQPVYTPIE..KHNSTSLPATF
  481-  619 (201.09/108.86)	LASCIRTNAPPAAAVtGAAVGGGAAATggTVSSASGVAATTGRPSALQQLLDG..GAVHHHENGlHGGLLVFEVSALSCQYITVSLMHPY.EESLAT..........VEFDLANIANI.AVRIYCGEGeATDQHTLDRIScvLQRCMSIPVTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.22|      22|      35|    1526|    1547|       4
---------------------------------------------------------------------------
    6-   27 (37.32/14.65)	TAAVGGGSGTLPALLMANGGSG
 1527- 1548 (39.91/16.34)	TSAVGGSGGTLANCVPSSAGIG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08042 with Med1 domain of Kingdom Metazoa
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