<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08035

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSASGATAIGGGSLPALLMANGGGGGSGGSGGPGGVGVGKGIGKPDMKPPGGLTVGGMGTAGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFPEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSVQHFSDVHSQLLKAPLGVVQKRRGGHPMRLTYFVAPYELLDLGSRTINALSAELIAKERIGCSVAVVLEASSANKLQIQPLLVGSGSAAPLGQPVYTPIEKHNSTSLPATFVLRLSKPMPINSAMMRAIRGIVGGSGTGDQAGEGMASSSSASGLPGSLLGLIAHHASGGNVTDLAKGLLVSLPDQYHCYYLTDNPSLRGVMVSSIPFTEPQHVPKILTYLRQQAIFNQLLSSCIRTNTPAASGGRPSALQLLLDGGVHTIENGLTGGLLVFEVSALSCQSITVSLIHPYEESLATIEFDLQNIANIAVRIYCSEGETSDEHTLQRISAVLQRCMSIPVTLRALIKVWEEEHEQKFKPNVLGSSTISSSGAGSGPGAGGAGGAGPGLNNGGDGSAGTGSGVSGPGEDGTMNGFNLASLGGPGPTLDAAGGGGGGGSAATNGTSLLPSGQRVLMNGEGNGLTLSGSNNNLGLDFCDMLTERNGNGFGGMAAIGSGGRTASGLGVREPPEALAGGAAKKRRMEDFCKSPKSDSNLSVGGGGGGSSCDSNISVEKHTTTITTITSQDVGAAATSGRTAASNEQRMQTGGATEEDIGGLSLFGGTVPASGTDAKGSSLGGTTTNTMISAKNEPPRVLPGDDDTGGAGVKMPLQSSSSSSLSSLSSSGFSLTGTASGEAAPDRPCPGTLLLESLDFSALETATSKRSTVTGGQSTKRRRSSSSSSSSSSSSSSSSSSSSSTSDELEESVDLVEAEMSSFFAEGNSTPPVTAASKSSFGSSSGKPALGTVIPISNKIVSPSAGIGLEKGSSTTSSTGLEIIPLATTGAGTTAASGFASTPSTSASITLASTSAPSSTPSASTSSSSSKKSSSSSGSGHRKGTESTERSSSSKSEKKKKRKADDTGHLAMGPPNKLPFKSGESSPHRSGIGSSSSKSSPKHSSPVHHSSPKHAGSGALGFHSPKHGSSVSPKHPLHTGGSSTGGGKPSMSALKSAAASGSSPGTKSSDGSGGGAGGAGISAMGSSSKEREKERSEKKALQFSSNSNTTAGSSLTSNSNAGSSSVGKSKNSHLKLKQLDLAAGSSMTISMAASGDSGTSSPVAPMIDLTSPGQGSTLGALGLPGAGLTTTSSMLQALQSAKNRKAPSSAGSTGLGGSLSAVIDKLKSAQSADDEAVLVLPEMTITQQTTSTPIGGGSGGIGAGVNLGGYGAALKDSSKSGNSLLSGSGSSSMALTQSSAMTTAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSNKSSSSGGSKSGSKSGLKSGVSTSGPVSSKQQQSNHTTSFSGAFPSSTKSPHYTSSTSGSSKTPFQKSNSFGSLGGGGTGIKASKVSSPKSTSNPASSSSSSYSTSKEKGSGAASGRSKSSVSSLSGAMLTGGASGGSGTGSSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNNSSTGTGAATGQNESSEGSKGTKELTARKQKQQTPITTSSAQPVGSQPIKQFSSSSSGEASAKLLSDLLGAAAKSGNKMASGVAGVSSGDGAALHPLLPNIVQKMFGSDGSLQTKSNSSDGNMFPTAGRASPGMLSGSASRDGFRTSGSGSAPGTPTTTGSMVMPPFPSPVSGGASNDGDVGSSGAGSLMRPPSRPSSTVSNHSHSSQDGIGGAASNSGDVGTPSVTSMASMMMMSAMSAAAGGQSPGSASLPLDSTSTQQLIAALAAKSGAAAGGVLPPPGSLLNNHTNHLHHHGNHLNNHVAGGMAALKNLQSSASMSVHIVKSPAPSSLPFTSPHSNASSSHGSGAGAGGLDDDLMDEALIGIGSK
Length2078
PositionMiddle
OrganismAnopheles epiroticus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.285
Instability index49.30
Isoelectric point9.23
Molecular weight206940.58
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08035
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            14|    1232.03|     111|     112|    1458|    1568|       1
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  697-  829 (71.05/ 9.76)	S..LLP....SGQrvlmngE....GNGL.tLSG....SnnnlgldfcdmlterngnGF....GGMAAIG.....SGG..RT..............ASGLgvrepPEAL.A..GGAAKKR..RME...............DFCK....SPKSD.SNLSVGG..G.........G...............GGSS.CDS..NI.SVEK....HTT....TIttitsqdvgaaatSGRT.....A
  840-  919 (82.32/12.70)	G..ATE....EDI......G....GLSL..FGGtvpaS..................GTdakgSSLGGTT.....TNTM...............................I..SAKNEPP..RVLP..........................G.DDD...T..G.........G....AGVK...MPLQS..S.SSS..SL.SS........L....SS.............SG.F.....S
  928- 1021 (86.67/13.84)	A..APD....RPC......P....GTLL..L...............................ESLDF........SAL.ET..............ATSK.....RSTV.T..GGQSTKR..RRSSSS.....................SSSS.SSSSSSS..S.........SSS..SSTS...DELEESVDlVEA..EM.SSFFAEGNSTP....PV.............TAA.......
 1022- 1106 (76.10/11.08)	...........SK......S......SF..GSS....S..................GK....P...........................................ALgT..VIPISNK..IVSPSA.............GIGL.....EKG.SSTTSST..GleiiplattGAG..TTAA...SGFASTPS.TSA..SI.TL......AST....SA.............PSST.....P
 1108- 1205 (106.06/18.89)	A..STS....SSS......S....KKS...SSS....S..................GS....GHRKGTE.....S.............................TERS.S..SSKSEKK..KKRKAD............DTGHLA.M...GP.PNKLPFK..S.........GES..SPHR...SGIGSSSS.KSS..PKhSSPVHHSSPKH....AG.............SGAL......
 1209- 1298 (87.69/14.10)	..........SPK......H....GSSV.........S..................PK....HPLHTGG.....SSTG.GG..............KPSM.....S.AL.K..SAAAS.......GSS............PG......T..KS.SD...GS..G.........GGA..GG.........AGIS.AMG..S..SSKEREKERSEkkalQF.............SSNSnttagS
 1299- 1384 (81.93/12.60)	S..LTS....NSN......A....GSSS..VGK....S..................KN....SHLKLKQldlaaGSSM.TI................SM.....AASG.D..SGTSSPVapMIDLTS............PG...............................................QG.S.TLG..AL.GLPGAGLTTTS....SM.............LQAL.....Q
 1386- 1459 (63.49/ 7.79)	AknRKA....PSS......A....GSTG..LGG....S..................LS....AVID...............................KL.....KSA..Q..SADDEAV..LVLP.................EMT.I......TQQTTSTpiG.........G.....GS....GGIGAGVN.LGG.....................Y.............GAAL......
 1460- 1568 (176.10/37.15)	....KD....SSK......S....GNSL..LSG....S..................GS....SSMALTQ.....SSAM.TT..............APSL.....TAAL.T..SGKASEY..MVKPSS............DGIKLT.IQNKKG.SNKSSSS..G.........GSK..SGSK...SGLKSGVS.TSG..PV.SSKQQQSNHTT....SF.............SGAF.....P
 1579- 1652 (58.04/ 6.37)	S..TSG....SSK......TpfqkSNSFgsLGG....G..................G................................................T..................................GIKASkVSSPKStSNPASSS..S.........SSY..STSKekgSGAASGRS.KSS..V............S....SL.............SGAM......
 1658- 1770 (81.11/12.38)	...................S....GG.....SG....T..................GS....SAL.VNP.....ISIM.KMlgyptgsmgnmegfAKSL.....DTKF.Q..IPKLSAR..SNNSST............GTGAAT.GQNE.....SSEGS..K.........GTKelTARK...QKQQTPIT.TSSaqPV.GS.QPIKQFSS....SS.............SGEA.....S
 1771- 1877 (93.53/15.62)	AklLSDllgaAAK......S....GNKM..ASG...vA..................GV....SS...GD.....GAALhPL..............LPNI.....VQKM.F..GSDGSLQ..TKSNSS............DG........NMF.PTAGRAS..P.........GML..SGSA...S..RDGFR.TSG..SG.SAPGTPTTTGS....MV.............MPPF.....P
 1879- 1943 (82.17/12.66)	P..V...............S....GGAS..NDG....D..................VG....SSGA.........GSL.MR..............PPS.........................RPSS.................T.VSNH.........S.................HSSQ...DGIGGAAS.NSG..DV.GTPS.....VT....SM.............ASMM.....M
 1950- 2058 (85.77/13.60)	A..AGG....QS.........................P..................GS....ASLPLDS.....TSTQ...................QL.....IAAL.AakSGAAAGG..VLPPPGsllnnhtnhlhhHGNHLN.NHVAGG.MAALKNL..Q.........SSA..SMSV...HIVKSPAP.SSL..PF.TS..PHSNASS....SH............gSGA.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.19|      26|      47|     620|     647|       3
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  621-  647 (45.89/16.90)	SSSGaGSGPGAGGAGGAGPGLNNGGDG
  670-  695 (48.30/12.54)	ASLG.GPGPTLDAAGGGGGGGSAATNG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.95|      11|      17|       1|      11|       4
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    1-   11 (19.32/ 6.24)	MSASGATAIGG
   19-   29 (21.63/ 8.21)	MANGGGGGSGG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.43|      19|      20|     420|     438|       5
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  401-  418 (20.90/ 6.39)	.ASSSSASG...LPGSLLG.LIA
  420-  438 (31.46/13.59)	HASGGNVTD...LAKGLLV.SLP
  440-  461 (23.08/ 7.87)	QYHCYYLTDnpsL.RGVMVsSIP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.05|      16|      16|     111|     126|       6
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  111-  126 (24.96/19.32)	YALDAVEKSNLQKTLD
  130-  145 (27.09/21.68)	YCIKVTTRQGLVERLD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.80|      45|      49|     210|     254|       7
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  210-  254 (72.37/61.17)	FADFTTQL..EGLASIYQLNAEKKIKVNAFVA.LQALETDLHTLYTLS
  258-  305 (67.43/56.33)	FSDVHSQLlkAPLGVVQKRRGGHPMRLTYFVApYELLDLGSRTINALS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.37|      22|      49|     326|     347|       8
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  326-  347 (36.99/19.42)	SANKLQIQPLLVGSGSAAPLGQ
  377-  398 (38.38/20.49)	SAMMRAIRGIVGGSGTGDQAGE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.61|      14|      20|     552|     567|       9
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  552-  567 (20.42/26.76)	EFDLQNIANIAVRiyC
  575-  588 (25.19/21.71)	EHTLQRISAVLQR..C
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.60|      21|      22|     479|     499|      10
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  479-  499 (35.40/17.72)	AIFNQLLSSCIRTNTPAASGG
  502-  522 (32.20/15.43)	SALQLLLDGGVHTIENGLTGG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08035 with Med1 domain of Kingdom Metazoa
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