<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08030

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMESHVFHKARNKDEYLGFVARLILHVREMNTKHKNQQNAAAAAAAAAAAQQAQQDGGAGNSGQQGGGGGGGGGGSGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMAGQMGGAGQASNLLHSLRPQMQMGGMGGPMQGNRVGMGPGPGNQMGAMMGGPNQMQGPGSGMVGGMQAQMGVGIGPGGMSGGKIVGIGGQQQQMAQLSAMQVNQMQQAQQQQQQQGGMPQSQQQQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQNAMGGQQMGAGNQMGPMVGANAGMNPQPMGMASNQVLRQQQQQQQQQQGMGGVQMGLGPGQMGQLSAGVQGGVGHVGPGPNMGQVQQQQQQQHQQQHQQLQQHLQQHPQQHQQMQQHQQQMQQQQQQQQLQPQLQQQQMQQHQQHQQMQQHQQHQLQQQQQQQQQQQQQQQQQHGQHPQQHPQQQQQQQLQQQQQQLQQLQQHGHPQIQQQQQQQQHQQQQVLLNAMGQGPGVVGAGVGPIGAPIGGPGGPGVTMQTMQQQQQASGMGQAGPNQMNAGVPMGPGGGGGVMGPGPNQMLGAGGAAGGPGGAGQQGNFVGMGGNTMVRKPPDMYPGAGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPQSHPGQMIPSPALIPSPNPHMGGVAQRSTIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYRALTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILSNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAVSSSLQSASGNHTLQRTFRPCLEAMFGPDIKNLPPPAKQPRLAAMDDTAASGGATSGGATTTSTTAPSTTTAGSSGSSSTTATGTSAVSATPTPQEIPHILQGEIARLDQKFKVSLDQCAINGTRTIKLICWLDDKNLPCVPPVAVTIPEDYPTTSPSCSLIEQEYNATPFLILVQKSLMARICKLPGFFSLSHLLDTWEMSVRQACSPNPTIVAPTGTSVLLGM
Length1033
PositionTail
OrganismAnopheles epiroticus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.02
Grand average of hydropathy-0.698
Instability index58.40
Isoelectric point9.18
Molecular weight108541.84
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08030
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     325.88|      33|      33|     398|     430|       1
---------------------------------------------------------------------------
  124-  154 (51.20/ 9.18)	LASQGTR...PQ......MMG.QM.G.VG.PG......GP..MAG.QMGGAGQ
  252-  297 (43.84/ 6.16)	QAQQQQQ...QQggmpqsQQQ.QG.QgGPVQQmgvgpgGP..NQMNPMVMGQI
  392-  423 (65.12/14.91)	Q.QQQQH...QQ......QHQ.QL.Q.QHLQQ......HP..QQHQQMQQHQQ
  424-  457 (57.46/11.76)	QMQQQQQ...QQ......QLQpQLqQ.QQMQQ......H...QQHQQMQQHQQ
  459-  492 (57.27/11.68)	QLQQQQQqqqQQ......QQQ.QQ.Q.QH.GQ......HP..QQHPQ.QQQQQ
  493-  523 (51.00/ 9.10)	QL..QQQ...QQ......QLQ.QL.Q.QH..G......HPqiQQQQQQQQHQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.36|      18|      22|     570|     590|       2
---------------------------------------------------------------------------
   93-  110 (32.20/ 6.07)	GGAGNS..GQQGGG.GGGGGG
  569-  589 (30.16/13.54)	SGMGQAgpNQMNAGvPMGPGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.39|      18|      22|     164|     185|       3
---------------------------------------------------------------------------
  179-  201 (27.36/ 7.17)	RVGMGpGPGNQMGAmMGGpnqMQ
  229-  246 (30.03/ 6.30)	IVGIG.GQQQQMAQ.LSA...MQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.94|      27|      38|     662|     691|       4
---------------------------------------------------------------------------
  662-  691 (40.03/12.23)	SPVGPGAHGPQSHPGQmiPSPAlIPSP.NPH
  699-  726 (42.90/ 8.09)	STIGQSPGGSLNTPGQ..PGGA.VPSPlNPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     173.24|      39|      51|     302|     340|       5
---------------------------------------------------------------------------
  311-  357 (73.57/21.29)	QMGAGN.QM...GPMVGANAGMNPQP..MGMASNQVlrqqqqqqQQQQGM.....................GGV
  538-  592 (46.80/ 9.98)	.VGAGV......GPI.GAPIG.GPGG..PGVTMQTM........QQQQQAsgmgqagpnqmnagvpmgpggGGG
  593-  642 (52.86/12.54)	VMGPGPnQMlgaGGAAGGPGGAGQQGnfVGMGGNTM.......vRKPPDM.................ypgaGGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.37|      16|      18|     856|     873|       6
---------------------------------------------------------------------------
  856-  871 (28.75/19.50)	TAASGGATSGGATTTS
  879-  894 (28.61/12.27)	TAGSSGSSSTTATGTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.72|      22|      51|     156|     177|       7
---------------------------------------------------------------------------
  156-  177 (44.17/13.10)	SNLLHSLRP..QMQMG..GMGGPMQG
  205-  226 (41.09/11.63)	SGMVGGMQA..QMGVG.iGPGG.MSG
  365-  387 (29.46/ 6.05)	Q..MGQLSAgvQGGVGhvGP.GPNMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.11|      16|      16|     742|     757|       8
---------------------------------------------------------------------------
  742-  757 (26.96/19.83)	IEPLKRMIAKMENDDI
  760-  775 (25.15/18.03)	IAKMKRLLEILSNPSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.20|      20|      23|     789|     808|      12
---------------------------------------------------------------------------
  789-  808 (34.02/19.51)	LTSQLGSIRETPTNN....PLVEA
  809-  832 (29.18/15.62)	VSSSLQSASGNHTLQrtfrPCLEA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08030 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALTSQLGSIRETPTNNPLVEAVSSSLQSASGNHTL
2) AQLSAMQVNQMQQAQQQQQQQGGMPQSQQQQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQNAMGGQQMGAGNQMGPMVGANAGMNPQPMGMASNQVLRQQQQQQQQQQGMGGVQMGLGPGQMGQLSAGVQGGVGHVGPGPNMGQVQQQQQQQHQQQHQQLQQHLQQHPQQHQQMQQHQQQMQQQQQ
3) MAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMESHVFH
4) PDIKNLPPPAKQPRLAAMDDTAASGGATSGGATTTSTTAPSTTTAGSSGSSSTTATGTSAVSATPTPQE
5) QQQQQQQQQQQHGQHPQQHPQQQQQQQLQQQQQQLQQLQQHGHPQIQQQQQQQQHQQQQVLLNAMGQGPGVVGAGVGPIGAPIGGPGGPGVTMQTMQQQQQASGMGQAGPNQMNAGVPMGPGGGGGVMGPGPNQMLGAGGAAGGPGGAGQQGNFVGMGGNTMVRKPPDMYPGAGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPQSHPGQMIPSPALIPSPNPHMGGVAQRSTIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKY
6) VREMNTKHKNQQNAAAAAAAAAAAQQAQQDGGAGNSGQQGGGGGGGGGGSGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMAGQMGGAGQASNLLHSLRPQMQMGGMGGPMQGNRVGMGPGPGNQMGAMMGGPNQMQGPGSGMVGGMQAQMGVGIG
788
240
1
836
467
63
822
430
44
904
735
220










Molecular Recognition Features






MoRF SequenceStartStop




NANANA