<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08028

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPQPLEQGGAVTSFIPTGQEMAQRQNLIPLGRLIDFIIQRTYHELTVLAELLPRKTDMDRKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMGFLDKQSMLFIDTADMLSRVARETLVHARLPNFHIPAAVEILTTGSYSRLPSVIRDRIVPPDPITPAEKRQTLQRLNQVIQHRLVTGSLLPQLRKFRIENGRVTFKVDHEFEVSLTVMGDAPTVPWRLLDIDFLVEDKETGDGKALVHPLQVNYIHQLIQGRIVDCTDALAEVYTCLHYFCQSLQLEVLYTQTLRLIRDRLDDHIHVDEYIVGSRLTVSYWRELTNKDPKSELGYRLTIQTDPNDAAKQLAILHVPSIGNKEADIADRAVRSDLLSMERLLVHTVYVRSLARLNDVKTELQLFLKDVEYNIQGTPAMLTVPVLNPCLRAEHIYITVDTHTGMLRCHVPKHLDCPIMPDMQHALNNDWSKLQHLISELRYWITQRRCEKTLQHLPAATQDRLPLIYPQNHPIARMGPHKVFIQLYRHANIILIVELKEKTTCPNEMTYTFYMVLVKPSSVEEGQTQDAASGQTGQPGGQSSNTDTATMPKMYLRVLSMIEFDTFVATHGPGTYIDDSCPTSTNSGSIKRKVSPLDNALSGIGPPLKQQKTIYPAYFIPELAHVVAMCDEKLPFVTLAKEFTMRKIPHGGLQVEANATSLVLKLLTLPQPKPPQAAPTAQQQQQHEPGPSSAKPGAAATANESPRTVLVPPIDKHVWNALLKRLLSVSVRAQVNKSNQTRLWTVELVFYGSPLPSLHHKEQGMRRAVYLQYEMQPVESVSKVVDQLLSDWSKIVYLYTLVHEFREQFNNEKYNLQSMVTIKSYSYTNLLLAYGPNKDVSVNIWWDTEGKEFRLVFTGGNSAINAHSMMRDQLQAHLNHNYSLAQIVHMLHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRFRGGGLCTIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVFRRRSQSEDDNPPSPVTMEDPSGHVGAGTGAGNSGGAGGGAGGAGGGSNTFLSGGTGMRGPQSPRDPGLRFAAPLTPPTSSNPHTPASPHPIGGGGGTGGAGGAGGQAGGQGVQQQGHMNNFNMTSPPASHMPHPSPGGLMPSSPLNAQPSPMAAHSPGPSSLSYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYTSRVLPARSWAGAIPTTLTYEALDTLCRATPHPQKEVPGPELSPLERFLGSVFMRRQLQRIIHSEESLMAITSNEPGVVVFKADCLQYQVFLNPNHMQSLHLKVDQLPMGPMMDGKPPYQWAAQDLQILEQFFDQRVAAPPYRPAVMTSFTRMLNLPAKVLKDFIQIMRLDLMPELVQGNKWNVQFVLRVPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMEWKDAVTMLLPMVYDMNMNHTTLAERREPMPPQLTSAVSAHLRRFSECSVLLPDECSLFPAVHDLLLTLTLPNEPPAPGQMQMQLGGVMQPGGGPGGPGGPGGPMGGQIGGPTQQVVPQVGSSPSPMMHSPMQQMGGGGQQPGAYGGMVGGPGGGPQSGGPGGGGPGGPN
Length1635
PositionTail
OrganismAnopheles epiroticus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy-0.271
Instability index50.49
Isoelectric point8.49
Molecular weight179757.32
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08028
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     391.54|      58|      58|    1029|    1086|       1
---------------------------------------------------------------------------
 1029- 1086 (103.48/41.31)	RRSQS.EDDN........PPS...PVTMEDPSGHV.GAG...TGA.GN....SGGAGGGA..GGAG....GGSNTF.LSGGTGMRG
 1087- 1158 (74.20/27.44)	..PQSpRDPGlrfaapltPPTssnPHTPASPH.PI.GGG...GGT.GG....AGGAGGQA..GGQGvqqqGHMNNFnMTSPPASHM
 1159- 1217 (76.98/28.76)	PHPSP.GGLM........PSS...PLNAQ.PSPMA.AHS...PGP.SSlsymQSHTDGSP..FAAL....SPAASN.WPGSPGM..
 1540- 1582 (70.25/25.57)	..................PPA...PGQMQMQLGGVmQPG...GGP.GG....PGGPGGPM..GGQI....G........GPTQQVV
 1583- 1634 (66.63/23.86)	PQVG.....S........SPS...PM.MHSPMQQM.GGGgqqPGAyGG...mVGGPGGGPqsGGPG....GG...G..PGGP....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.83|      23|      80|    1370|    1395|       2
---------------------------------------------------------------------------
 1370- 1394 (34.57/23.54)	FFDQrVAAPPYRPAV.MTSFTRMLnL
 1452- 1475 (36.26/15.40)	FFIQ.ITRVPYLPNMeWKDAVTML.L
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.03|      52|     339|      23|      80|       4
---------------------------------------------------------------------------
   23-   80 (72.51/70.58)	AQRQNLIPLGRLidfIIQRTYheLTVLAELLPRKTDMD...RKIEiYNFSASTRQLFIRLL
  368-  422 (80.52/56.11)	AVRSDLLSMERL...LVHTVY..VRSLARLNDVKTELQlflKDVE.YNIQGTPAMLTVPVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.82|      15|      17|    1224|    1238|       8
---------------------------------------------------------------------------
 1224- 1238 (29.51/16.62)	PGQSPEHKVQTSHHY
 1244- 1258 (27.31/14.79)	PARSWAGAIPTTLTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.57|      37|     141|     125|     167|       9
---------------------------------------------------------------------------
  125-  167 (56.06/53.46)	VHARLPNFHIPAAVEILttgsYSRLPSVIRDRIvpPDPITPAE
  272-  308 (67.51/45.26)	VYTCLHYFCQSLQLEVL....YTQTLRLIRDRL..DDHIHVDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.23|      31|     551|     940|     978|      11
---------------------------------------------------------------------------
  489-  519 (57.11/28.40)	LQHLPAATQDRLPL....IYPQNHPIARMGPHKVF
  942-  976 (48.12/36.10)	IPHLAILQSPKIPVlsfcIIPQSPTLLRISFQGVY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08028 with Med14 domain of Kingdom Metazoa
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