<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08025
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSLSANISVEAPIENQIQEIAYDGTEIYQLPPTLSEHLAKCATKIDFSKTSSDIDLLQQSIKKEDEKKEEESKDPKEQFQSSLWPWDSVRNKLKEALTEVCVLSDVLNIAKEKRYMVLDPIPQEPPEVKQMVMVYARKKALASAANILQSGVERLKAVQSDQGVTRTNSSDFHIELLRLRRNWRLKKVSNTIIGDLSYRTAGSKFMHPGMFEVTKAEDEESGSPPASPSGSGAAGTVACPKINSALRVNVPTELQGVAFIKVITQKDQEDLCTATVNMMGSTQLVPQAGAWQQTLEYAQNVLFCKELFNQLAREAVQLQAPIPHVVVGNQIRATLLPGIQLIISLCHSTSSDSNNSSEPIKDHDHVLEHSLHQLLREFHHKNTHHPFPHPASGPLGPSKKRMLAGPSAYDRHELLEMTKSQTLLEQIIAQAQHIFTRRRTQYVLDTVARDVKDPMITSHWNAMNSPTMSCVKINITSHGYDANLRTSLVIHVKERSLKCICRDGRIMHMSYEPQELRDLILCQISQHQIVCLQNLAKCMAWQILSSSSHLGIGAVEPLGNASSCVLASPNSDRLIAVQVRCDSQIDVKVFIAQSPAKDFFPGSLVRFDKMEGKNFHNKMEFLMASLTSQS |
Length | 630 |
Position | Head |
Organism | Anopheles epiroticus |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae>
Anophelinae> Anopheles.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.320 |
Instability index | 60.03 |
Isoelectric point | 7.09 |
Molecular weight | 70280.72 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP08025
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 139.11| 44| 162| 391| 435| 1
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391- 435 (72.28/44.27) ASGPLGPSKKRMLAGPSAyDRHELLEM.TKSQTLLEQIIAQ..AQHIF
554- 600 (66.84/36.39) AVEPLGNASSCVLASPNS.DRLIAVQVrCDSQIDVKVFIAQspAKDFF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 83.66| 26| 129| 348| 377| 6
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348- 377 (40.03/33.30) STSSDSN.NSSEPIkdhdHVLEHSLHQLLRE
477- 503 (43.63/25.85) SHGYDANlRTSLVI....HVKERSLKCICRD
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