<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08021

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLIPKLHEHYHQGPLQEKPMAGGAGNSAGMGSAAGGLGLGVGTGGTNPSTIPPPLSSPAGSMHSPAGGNPVGGSMHAQQQPISPQEEQRIAVKQWNYSTGLCKYLYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLYDIVQSERFCRRLAYGVSKKLAQLINQMAESHNINLSCTEPQDGSGKQPGAEVADGKTDKQTDKPPKEGTMVGAAAAPFAETKPPKVNPYEMIFAEYLQCSHHRDVILQLSSILQVITLECPTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPMPMRYEKTNEELRAKLFEAEERIKVRSRHAESRWCIDKWQTAAGNASLKILATLDALDGHCFDRMDSNNSLDSLYSKIFPPFQVQPIKPTDSASGGSNGSGGHGNLPPGGTATDGKDAATKQFEYNVEQDSSIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVLTALENDSYSNNLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLEDAGSTQNKSQFTNLVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDSGGICNAGLGTGPISNKPATSSSPNNGGVVEDDVVQTDFKGKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPAVTGLEKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFESTSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAVGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVELQLIGKSSMALVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKSRPQQEPFHNAYPKIKQALYTPLQPTPSAHTYNPQFMIDIITNPRRGGRIESAWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGTGKRSGLNTPVHPGSTPKSMAGSGDLSHILGTSDLSILGNPDESMLDVSMIELGELSPTASARLYSSRQQNSHLNQDNATSLSDFAQHVLRQICSQEWVLERCLQHAEELCQHGMLIDNLLTAKQAQRLLHMICYPEHETNLIAELDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSSDLSNWLDMVARAAIDVFRVNEFLLNSPDVKQEKVKPSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKHRDGNGGNSSSNNNSHNHGANSNSSVSSNGSTFGSKQSSQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYSQLSHFLQNRDQSLETIGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISLGVIDLNNNSELFTTTLDMLATLIHSTLVSDSQNERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVLTCDSAGSSTDAKGNKIAIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTNSKKAKTTRKRTKKATAAAQLHLQQQQVQQQQHLQQQQQLQQLQQQQQLQQQQQQQQNQMMMQQQQQSNIPQQQQSALQQQQQQQQQQQQQLGSQQAQQQQVTMTPQQTLQQMQSNSMGGMQMGGPMNSMNQQHMQQQYGQANASQLVGQGNMGGMQTGMGGLGAGMGGGMLNQQQQQQQQQQQQQQQQQQPQSQQQPQQVQQAQQGQQTQQQPQGNQNMGFVGNVNSMAQQLAQQQGGNQQWGGYGSMQQQHQQQQQQQQQQQQQQQQQQQQQQQPQTQAQQQQQQQTPQQGQQAPQQQAPQQGPQQGSQQGPQTQQQLQQQQQQQQMFYSGMGQATMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPGSFMQQQQQQQQQAQRNPQQPFLRGQLRAGMPGNPIVGAQTGMGAMNAAMAGGTAGIGTTGAGAVMGAQSMTAGGMMGAQQSAQGQQSAGGIMNQNTPAMMGTTGGSIMGQSGGSMIQTSMMNAQQNSSLVGQGMGGGSGGIGGAGGMTGNSGMGGNAGGMGGSSGGMVTSGGMVTAGMGNTGIGNATPMGGGQSGMGANTGMSTTGGMGNPSMGNPGMGMQNMQQSGNMQGGMFQGQNVPYQNVNQNYPNYGNQGMGQQSGQAGGMMGNFNPMAQQQRNTQAEFLAQQRAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNMAQNQQQFQQQRMRLIMQQHSGMGQGANAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
Length2737
PositionKinase
OrganismAnopheles epiroticus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.06
Grand average of hydropathy-0.582
Instability index51.09
Isoelectric point6.84
Molecular weight299167.37
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08021
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|     816.81|      81|      84|    2099|    2180|       1
---------------------------------------------------------------------------
 1982- 2031 (56.18/11.67)	.....................LQ.QQQVQQQQH....LQQQQQLQQLQ.QQQ.QLQQQQQQQ.......Q......NQmMMQ...QQQ.....QSNipQ..................
 2032- 2075 (48.68/ 9.12)	......................Q.QQSALQQQQ....QQQQQQQQQLG.SQQaQQQQVTMT...............PQ.QTL...QQM.....QSN.....................
 2076- 2109 (52.37/10.51)	.SMGGMQ..MGGPMNSM.....N.QQHMQQQ........................................................................ygQAN..ASQLVGQ
 2110- 2195 (160.99/48.32)	GNMGGMQTGMGGLGAGMGGGMLN.QQQQQQQQQ....QQQQQQQQQPQ.SQQ.QPQQVQQAQ.......Q......GQ.QTQ...QQP.....QGN..QNMGfvgNVNsmAQQLAQQ
 2196- 2255 (105.76/28.52)	Q..GGNQQ.WGGYGS......MQ.QQHQQQQQQ....QQQQQQQQQQQ.QQQ.QQQPQTQAQ.......Q.......Q.QQQ...QTP....qQGQ..QA.................
 2256- 2311 (55.58/11.60)	.........................PQQQAPQQ....GPQQGSQQGPQ.TQQ.QLQQQQQQQ.......QmfysgmGQ.ATMnrfDRP.....QLN..TN...............SK
 2312- 2364 (72.35/17.17)	QALSNMLRSKLPINAGHPGSFM.......QQQQ....QQQQQAQRNPQ.....QP.....FL.......R......GQ.LRA...GMP......GN..P..................
 2367- 2439 (73.23/17.47)	....GAQTGMGAMNAAMAGGTAGiGTTGAGAVM....GAQSMTAGGMM.GAQ.QSAQGQQSA.......G......GI.MNQ...NTPammgtTGG..SIMG...............
 2514- 2582 (75.50/18.24)	....GNATPMGGGQSGMGANTGM.STTG...GM....GNPSM..GNPGmGMQ.NMQQSGNMQ.......G......GMfQGQ...NVPyqnvnQNY..PNYG...............
 2583- 2639 (70.07/16.39)	.....NQ.GMG.QQSGQAGGMMGnFNPMAQQQR....NTQAEFL......AQ.QRAAMA.AG.......R......GQ.YGQ...HAP.......N..VTMG...............
 2655- 2709 (46.10/ 8.24)	...........GGKPGVGGNMAQ.NQQQFQQQRmrliMQQHS.....G......MGQGANAQgmmqnqgQ......GM.STQ...QTP.............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.50|      18|      21|    1347|    1367|       4
---------------------------------------------------------------------------
 1348- 1367 (26.09/25.67)	GI.LVVGDATAHKvsSIFGTG
 1371- 1389 (27.40/13.20)	GLnTPVHPGSTPK..SMAGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.79|      24|      27|    1743|    1769|       5
---------------------------------------------------------------------------
 1743- 1769 (36.35/32.27)	TTDwaiLFAQLI.SLGVIDLNN....NSELFT
 1771- 1799 (30.44/17.32)	TLD...MLATLIhSTLVSDSQNerdeNKKLYT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.66|      17|      19|    1847|    1863|      10
---------------------------------------------------------------------------
 1847- 1863 (28.48/18.75)	GNKIAI...DSIE.KKNGLRL
 1864- 1884 (21.18/11.80)	GDKQRVsvwDLLEgHKNPAPL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08021 with Med12 domain of Kingdom Metazoa
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