<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08019

Description Uncharacterized protein
SequenceASSFSSVSSFDYLLSQSQSHHQEQSSYHQSHLSQEQQQQQQQQQQQHHQQQQHHHHPQSSLGHSHHEQQHHHQQQQQQQQQHHHQQHHHHLQLSTSGLDKFVELFSSAQPHTPAESITTESYLADQTQHSNSSSDTLVGLEDNPSTFGGSSDSIPSALLKATYKEELPSPFSAGPSTRAPTTEPPDTDLLFESSSTEELGLLTLRSSSDPVLASSARLPQAIVHAQQGVGQVGRPSPSAAGPSSVESATAAAAAAASLLPSFQETYPIKYNQLASYGLKMDDDCFKMAASPHHHQAVTAAYAHHGSVYGHGHQHHHHHHHAGTGGVVGGVGLVGTGLHQGHYEFGTHTGGATGGGITQYNNPTGPPGSGGGSGGGGGGGGGTATGSFYSPSYEQHPAGYGGQVGTQDTYSLPPFPSVAELHVTTTCHRRSSLPIQRSESTSSSESPKPPRIAIYNKYAALPSASSSASSSPGYMNNNNPNTINNNEVAAAAAAAAAAAAAAAAASSAGIVGASASAPVVAPPPTAATVPRATPTSQSPSQLCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKACPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQESPPSPPVSMITALVRAHVDTTPDLASLDYSQYREPGQNEPIITEAEKVQQFYNLLTTSVDVIKHFADKLPGYNDLSVEDQELLFQSASLELFVLRLSYRARSDDTKMTFCNGVVLHRHQCQRSFGDWLNAILEFSKSLHAMQIDISAFACLCALTLVTERHGLREPKKVEQLQMKIISSLRDHVTYNSEAQRKPHYFSRLLGKLPELRSLSVQGLQRIFYLKLEDLVPAPPLIENMFLASLPF
Length876
PositionKinase
OrganismAnopheles epiroticus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy-0.520
Instability index60.92
Isoelectric point6.96
Molecular weight94252.35
Publications









Function






Annotated function


GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
nuclear receptor activity	GO:0004879	IEA:InterPro
sequence-specific DNA binding	GO:0043565	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08019
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.50|      31|      33|      24|      56|       1
---------------------------------------------------------------------------
   18-   51 (57.02/32.82)	QSHHQeQSSYHQSHlsQEQQ...QQQQQQQQQHHQQQ
   52-   86 (62.16/31.04)	QHHHHpQSSLGHSH..HEQQhhhQQQQQQQQQHHHQQ
  300-  316 (31.32/11.59)	AYAHH.GSVYGH.................GHQHHH..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     122.63|      23|      23|     318|     340|       2
---------------------------------------------------------------------------
  318-  333 (25.06/ 7.88)	...............HHHAG..TGGVVGGVGLV
  334-  357 (38.85/16.03)	GTGLHQG........HYEFGthTGGATGG.GIT
  362-  378 (35.56/14.08)	PTG..............PPG..SGGGSGGGGGG
  379-  404 (23.17/ 6.76)	GGGTATGsfyspsyeQHPAG..YGGQVG.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.29|      14|      16|     532|     545|       3
---------------------------------------------------------------------------
  532-  545 (26.38/13.01)	TPTSQSPS.QLCAVC
  548-  562 (22.57/10.13)	TAACQHYGvRTCEGC
  567-  578 (20.34/ 8.44)	KRTVQKGS.KY..VC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.64|      15|      16|     123|     137|       4
---------------------------------------------------------------------------
  104-  119 (17.33/ 6.03)	LFSSAQpHTPAESITT
  123-  137 (24.89/11.98)	LADQTQ.HSNSSSDTL
  140-  154 (22.42/10.03)	LEDNPS.TFGGSSDSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     243.57|      53|     202|     208|     262|       5
---------------------------------------------------------------------------
  155-  191 (52.37/21.92)	..............PSALLKATY...KEELPSPFSAGPST..RAPTTEPPDTDLL..F
  208-  262 (80.61/42.83)	SDP...VLASSARLPQAIVHAQQGVGQVGRPSPSAAGPSSVESATAAAAAAASLLpsF
  265-  299 (48.08/19.11)	TYP...I.....KYNQL...ASYGLKMDDDCFKMAASPHHHQAVTA............
  447-  498 (62.52/27.08)	KPPriaIYNKYAALPSASSSASSSPGYMNNNNPNTINNNEVAAAAAAAAAAA......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.99|      32|      34|     605|     636|       6
---------------------------------------------------------------------------
  605-  636 (55.18/37.59)	VGMVKEVVR..TDSLKGRRGRLPSKPKSPQESPP
  640-  673 (49.81/33.08)	VSMITALVRahVDTTPDLASLDYSQYREPGQNEP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08019 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HYEFGTHTGGATGGGITQYNNPTGPPGSGGGSGGGGGGGGGTATGSFYSPSYEQHPAGYGGQVGTQDTYSLPPFPSVAELHVTTTCHRRSSLPIQRSESTSSSESPKPPRIAIY
2) SFDYLLSQSQSHHQEQSSYHQSHLSQEQQQQQQQQQQQHHQQQQHHHHPQSSLGHSHHEQQHHHQQQQQQQQQHHHQQHHHHLQLSTSGLDKFVELFSSAQPHTPAESITTESYLADQTQHSNSSSDTLVGLEDNPSTFGGSSDSIPSALLKATYKEELPSPFSAGPSTRAPTTEPPDTDLLFESS
3) SLKGRRGRLPSKPKSPQESPPSPPVSMITA
4) TAAYAHHGSVYGHGHQHHHHHHHAGTGGVVGGV
341
9
616
298
454
194
645
330










Molecular Recognition Features






MoRF SequenceStartStop




1) EQSSYHQSHLSQEQ
2) PRIAIYNKYAALPSA
3) SSFSSVSSFDYLLSQSQ
23
449
2
36
463
18