<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08010

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMESHVFHKARNKDEYLGFVARLILHVREMNTKQKNQQNAAAAAAQQAQQDGSGNSGQQGAGGGGGGGGGAGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGGGNASNLLHSLRPQMQMGGMGGPMQGNRVGMGPGPGGQMGMMGPNQMQGPGGGMVGGMPGQMGVGIGPGGMSGGKIVGMGGQQQMAQLSAMQVNQMQQQQQQQQQQQGGMAQAQQQQQQGGMAQGQGGPVQQMAVGGPNQMNPMVMGQIQAQLQNQNVMGGGQQMGSVGGNMGSGNQMGPMVGANAGMNPQVMGMAANQVLRQQQQQQQQQGMPQVVNPNQVQMGLGPGVPMQQQAMQQQAGAMGQAGPNQMNAGVPMGGPGGVGPNVGGVMGPGPGQMLGGGGAGGAAGQQQANFVGMGAGGMVRKPPDMMPGGNVYPGGGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMGGVAQRSNIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYRSLTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILSNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAVSASLQGASGNHTLQRTFRPCLEALFGPDIKNLPPPAKQPRLAPDDATAGGAGSAGAAGGSAGTGSNAAATGTTTAATAATTTSGSSTGTGSSSSSAVTIATTTTAQEIPHILQGEIARLDQKFKVLVDQCAISGTRTIKLICWLDDKNLPCVPPVAVTIPEDYPFAAPSCSLIEQEYNATPFLILVQKSLMARICKLPGLFTLSHLLDTWEMSVRQACSPNPTIVAPTGTSVLLGM
Length873
PositionTail
OrganismAnopheles dirus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.02
Grand average of hydropathy-0.389
Instability index49.51
Isoelectric point9.18
Molecular weight89122.32
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08010
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     163.21|      32|      32|     346|     377|       1
---------------------------------------------------------------------------
  112-  139 (44.84/ 7.14)	PINALQNLASQGTRPQMMG....QMGVGPGGP
  153-  184 (51.84/ 9.36)	LLHSLRPQMQMGGMGGPMQGNRVGMGPGPGGQ
  346-  377 (66.52/14.01)	VLRQQQQQQQQQGMPQVVNPNQVQMGLGPGVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     292.96|      36|      36|     258|     293|       2
---------------------------------------------------------------------------
   80-  142 (38.88/ 6.05)	AAQQAQQDGSGNSGQQGAGGGGG...GGGGAGM.PdpinalqnlasqgtrpqmmgqmgvgpggpM....GG
  190-  213 (40.70/ 6.77)	PNQMQGPGGGMVGGMPG...QMG...VG.........................................IG
  258-  293 (78.18/21.52)	QAQQQQQQGGMAQGQGGPVQQMA...VGGPNQMNP.............................M...VMG
  379-  419 (49.44/10.21)	QQQAMQQQAG.AMGQAGPNQMNAgvpMGGPGGVGP.............................NvggVMG
  433-  461 (42.92/ 7.64)	GAAGQQQANFVGMGAGGMVRK........PPDMMP..................................GG
  491-  521 (42.84/ 7.60)	PVGPGAHGPPSHPGQMIPSPAL....IPSP...NP.............................H....MG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.13|      13|      19|     707|     719|       3
---------------------------------------------------------------------------
  707-  719 (23.06/12.24)	TGT....TTAATAATTT
  724-  740 (16.07/ 6.10)	TGTgsssSSAVTIATTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.49|      15|     158|     303|     317|       4
---------------------------------------------------------------------------
  303-  317 (31.38/10.65)	NVMGGGQQMGSVGGN
  463-  477 (25.11/ 6.55)	VYPGGGGAVRSVTPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.12|      17|      18|     217|     233|       5
---------------------------------------------------------------------------
  217-  233 (32.03/10.70)	MSGGKIVGMGGQQQMAQ
  234-  250 (28.09/ 8.40)	LSAMQVNQMQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.47|      13|      15|     570|     582|       8
---------------------------------------------------------------------------
  570-  582 (22.21/17.74)	IEPLKRMIAKMEN
  588-  600 (20.27/15.53)	IAKMKRLLEILSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.04|      11|      19|     655|     665|      15
---------------------------------------------------------------------------
  655-  665 (21.21/11.92)	RPCLEALFGPD
  671-  681 (20.83/11.57)	PPAKQPRLAPD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08010 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DIKNLPPPAKQPRLAPDDATAGGAGSAGAAGGSAGTGSNAAATGTTTAATAATTTSGSSTGTGSSSSSAVTI
2) MAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMESHVFH
3) QLSAMQVNQMQQQQQQQQQQQGGMAQAQQQQQQGGMAQGQGGPVQQMAVGGPNQMNPMVMGQIQAQL
4) QNVMGGGQQMGSVGGNMGSGNQMGPMVGANAGMNPQVMGMAANQVLRQQQQQQQQQGMPQVVNPNQVQMGLGPGVPMQQQAMQQQAGAMGQAGPNQMNAGVPMGGPGGVGPNVGGVMGPGPGQMLGGGGAGGAAGQQQANFVGMGAGGMVRKPPDMMPGGNVYPGGGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMGGVAQRSNIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYR
5) VREMNTKQKNQQNAAAAAAQQAQQDGSGNSGQQGAGGGGGGGGGAGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGGGNASNLLHSLRPQMQMGGMGGPMQGNRVGMGPGPGGQMGMMGPNQMQGPGGGMVGGMPGQMGVGIGPGGMSGGKIVGMGGQQQ
665
1
233
302
63
736
44
299
564
230










Molecular Recognition Features






MoRF SequenceStartStop




NANANA