<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08008

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSNLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLIPKLHDHYHQGPLQEKSSTGASGQSSGMSGTSSGGLGLNSGGAGSNPSTIPPPLSSPAGSMHSPAGGNPVGGSMHSQQQQQQQQQLSPQEEQRLAQKQWNYCTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLHDFVQSERFCRRLAYAVSKKLAQLINQMAESHNINLSSPESDANGKPTSSDTTDSKQEKQHEKTPKEGTPASATGTQTTDAKPAAKANPYEMIFTEYLHCSHHRDVVLQLSSILQVITLECPTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPMPDRYEESNEDIRRQLFEAEESMKVRSRHAESRWCIDKWQTAAGNASLKILATLHALDGHCFDRMDSNNSLDSLYSKIFPPFQVQSIKPTDSAGAGSGGNGAGSGGGAATSADGKDAATKQFEYNVEQDSSIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVLTALENDSYSQNLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLEEGGGSQNKSQFTNLVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDSHGICSNAGLGTGPISNKPATGSSPNNGGGLEDDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHAATSVTGLGKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFESTSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAIGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVELQLIGKSSVALVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKSRPQQEPFHNAYPKIKQALYTPLQPSPSAHTYNPQFMIDIITSPRRGGKIESAWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLTCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAQHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGTGKRSGLNTPVHPGSTPKSSGDLSHILGTSDLSILGNPDESMLDVSMIELGELSPTASARLYSSRQQNSHLNQENATSLSDFAQHVLRQICSQEWVLERCLQNAEELCQQGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCIPQELSNWLDMVARAAIDVFRVNEFTLNSSSSSSNSPDVKQEKVKPSTWLVAPLISKLPCAVQGRILKVSGQVLESTSMFSKHKEGNGGNSNSNNNSHSHGANSNSSVSSNGSTFGSKQSAQLNHQPFLGLVLTCLKHQDEQKEGLLQSLYSQLSQFLQNRDQSLESIGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVLTCDSAGSSTDAKGNKIAIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTGSKKSKTTRKRKPKATPAAQVQQSQSQQPIMPVIGPQAGAGPQQMQQMQQQQQQQQQQQQQQQQLQQQQQSLQQQQQQHLQQQQQQLHLQQQQQQQQHLQQQQQLLQQQQQQLQQQQNQMMMQQQQQQQSNIPQQQQQQALQQQQQQQLGPQQSQQQQVGMTPQQTLQQMQNANMGGMQMGGPMNAMSQQHMQQQYGQANPGQLVGQANLGGMQPGMGGLGAGMGGGMLNQQQQQQQQQQQQQQQQQQPQQQQQPQAAQQVQQAQQVQQAQQQQSQGNPNMGFVGNVNPMVQLAQQQQGGGNQQWGGYGSMQQQHQQQQQQQQQQQQQQQQQQQQPQSQAQQQQQTPQQAQQAGPQQQGPQQGPQQGAQQGLQQQMFYSGIGQGTMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPGSFMQQQQPQQQQPQRNPQQQFIRNQLRAGIPGNPIVGGPQAGMGPMNPAMAGGNAGLAAGAGGGAVMGAAPGMGAGGMMGAQQAAQGQQAAAGIMGQNTAAMMGTTGGSIMGQSGGSMIQAGMMNPGHNAAMVAQGMGGGGGAGGGGAGGIGAAGGMAGNSGMGGGGGGGGAGGMGGGGGGGMVTSGGMVSAGMGTAGLGGAATMGGGQGGMGGNAGGMPNAGGMGNPAMGNPGMGGMQNMQQSGNMQGGAMFQAQNVSYQNVNQNYPGYGNQGMGQQGGQGGGMMGNFNQMAQQQRNTQAEFLAQQRAAMAAGRQYGQHAPNVTMGSMGVNQGAVPPYPRQGGNPGVGGNMPQNQQQFQRMRQIMQQHSAGMGQGGNAQAMMQNQGQGMSNQQTPNLVAQLRQMPNQNNMMGQQYPHQPPQY
Length2811
PositionKinase
OrganismAnopheles dirus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.604
Instability index55.75
Isoelectric point6.73
Molecular weight305708.77
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08008
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     713.04|      78|      78|    2163|    2240|       1
---------------------------------------------------------------------------
 1960- 2026 (93.21/22.11)	.......PSSDQSP.A.PST..GS.KKS..KTT..RKRKPKATP..AA.QVQ..Q...SQ......SQQPIMPV....IGPQAGAG..P.QQMQQ.MQQQQQ...QQQ
 2027- 2064 (73.93/16.02)	QQQ.....QQQQQLQ...QQ.QQS...L..QQQ..QQQH..................................................lQQQQQ.QLHLQQ...QQQ
 2065- 2095 (47.86/ 7.77)	QQQH...LQQQQQ.........................................................................LLQ.QQQQQlQQQQNQmmmQQQ
 2096- 2163 (84.38/19.32)	QQQQsniPQQQQQ.QA.LQQ.QQQ.QQLgpQQS.qQQQVGM.TP..QQ.TLQ..QmqnAN....MGGMQ..MGG....PMNAMSQQHMQ...................
 2165- 2214 (90.30/21.19)	.....................................QYGQANP..GQ.LVG..Q...AN....LGGMQPGMGG....LGAGMGGGMLN.QQQQQ.QQQQQQ...QQQ
 2215- 2295 (136.63/35.84)	QQQQ...PQQQQQPQA.AQQVQQA.QQV..QQA..QQQQSQGNPnmG..FVG..N...VNpmvqLAQQQQGGGN....QQWGGYGSM...QQQHQ.QQQQQQ...QQQ
 2296- 2371 (109.72/27.33)	QQQQ...QQQQQQPQSqAQQQQQTpQQA..QQAgpQQQGPQQGP..QQ.GAQ..Q...........GLQQQM......FYSGIGQGTMN.RFDRP.QLNTNS...KQA
 2392- 2452 (77.00/16.99)	QQQQ...P.QQQQPQR.NPQ.....QQF....I..RNQLRAGIP..GNpIVGgpQ...AG....MGPMNPAMAGgnagLAAGAGGG......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     320.39|      39|      39|    2550|    2588|       2
---------------------------------------------------------------------------
 2478- 2517 (55.66/17.05)	AAA..GIMGQNTAA......................MMGTTGGSI....MGQSGGsMIQ........AGMMNPGHN
 2550- 2588 (80.98/28.43)	GMG..GGGGGGGAG......................GMGGGGGGG....MVTSGG.MVS........AGMGTAGLG
 2592- 2624 (66.18/21.77)	TMG..GGQ.....G......................GM.GGNAGG....MPNAGG.MGN........PAMGNPGMG
 2625- 2661 (40.14/10.07)	GM.....QNMQQSG......................NMQ...GGA....MFQAQN..VSyqnvnqnyPGYGN...Q
 2662- 2724 (35.60/ 8.02)	GMGqqGGQGGGMMGnfnqmaqqqrntqaeflaqqraAMAAGRQYGqhapNVTMGS.M...........GVNQ.GAV
 2729- 2761 (41.83/10.82)	RQG..GNPGVGGNM......................PQNQQQFQR....MRQIMQ.QHS........AGM......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.61|      13|     105|    2678|    2695|       4
---------------------------------------------------------------------------
 2678- 2695 (18.00/15.93)	NQMAQQQrntqaEFLAQQ
 2791- 2803 (24.62/ 9.79)	RQMPNQN.....NMMGQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08008 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLDKLLQHIKEDQQNSMDAPDSPKDPEHAATSVTGL
2) HDHYHQGPLQEKSSTGASGQSSGMSGTSSGGLGLNSGGAGSNPSTIPPPLSSPAGSMHSPAGGNPVGGSMHSQQQQQQQQQLSPQEEQR
3) HNINLSSPESDANGKPTSSDTTDSKQEKQHEKTPKEGTPASATGTQTTDAKPAA
4) LPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTGSKKSKTTRKRKPKATPAAQVQQSQSQQPIMPVIGPQAGAGPQQMQQMQQQQQQQQQQQQ
5) MNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKH
6) QGGMGGNAGGMPNAGGMGNPAMGNPGMGGMQNMQQSGNMQGGAMFQA
7) QQSQQQQVGMTPQQTLQQMQNANMGGMQMGGPMNAMSQQHMQQQYGQANPGQLVGQANLGGMQPGMGGLGAGMGGGMLNQQQQQQQQQQQQQQQQQQPQQQQQPQAAQQVQQAQQVQQAQQQQSQGNPNMGFVGNVNPMVQLAQQQQGGGNQQWGGYGSMQQQHQQQQQQQQQQQQQQQQQQQQPQSQAQQQQQTPQQAQQAGPQQQGPQQGPQQGAQQGLQQQMFYSGIGQGTMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPGSFMQQQQPQQQQPQRNPQQQFIRNQLRAGIPGNPIVGGPQAGMGPMNPAMAGGNA
8) SMFSKHKEGNGGNSNSNNNSHSHGANSNSSVSSNGSTFG
9) VNQNYPGYGNQGMGQQGGQGGGMMGNFNQMAQQQRNTQAEFLAQQRAAMAAGRQYGQHAPNVTMGSMGVNQGAVPPYPRQGGNPGVGGNMPQNQQQFQRMRQIMQQHSAGMGQGGNAQAMMQNQGQGMSNQQTPNLVAQLRQMPNQNNMMGQQYPHQPPQY
821
194
374
1937
1
2597
2122
1627
2651
856
282
427
2030
35
2643
2443
1665
2811










Molecular Recognition Features






MoRF SequenceStartStop




1) MNMRPLKRPRLG
1
12