<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08004

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSSGTAAAVVGGVSGTLPALLMANGGSGGGAGGKGLGKSDIKPPGSIGGPGGGPGTGGGTTGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFPEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSAAHYPDVQSQLAKAPLGLVQKRRGGHPMRLTYFVAPYELLDLGARTLNALSAERIAAERIGCSVAVVLEAASANKLQIQPLVVVSGGGAAAQPVYTPIEKHNSTSLPASFVLRLSKPMPINGAMMRAIRGIVGGAVEQAGGDGGAGSSSTGLPGSLLALIAHHASGGSVKDLAKGLLVSLPDQYHCYHLTDNPALRGVMVSSIPFTEPQHVPKILTYLRQQVVFNQLLASCIRTNVPPAAATATASTGALGSTGRPSALQQLLDGGAAHHEPGLGGLLVFEVSALSCQYITVSLMHPYEESLATVEFDLANIANIAVRIYCGEGQATDQHTLDRISGVLQRCMSIPVTLRALMKHWEEEHEQKFKPSVLGSAVPSTNGGGPGGGGGGTGPDGTGSGTGGAGSSEDTPMNGFNLSSLAGGGSAAAAPSSGDGGAGTPGSNATGTNSTTNGMNGGGGGVDTSGLDFCDMLTDRNGGREPPEPLAGGVAKKRRMEDFCKSPKSDSNLSAGGGGGVGEGVEMAGTATSTTTTTRDGLVVTVGRSEQQRTQQPPVGAPEEDTDGRVTTPAPAGGGVVDGKGSSLGGTTNTSATTTITTTTTTSNATASAALKTDAILLHLPDADLVKPVQSSSSSSLSSLSSSSSVAAASLGFTGAVVASGEPPERAPSAGTLLLESLEFSPTPTDRPSVKRRRSSSSSSSSSSSSSSSSSSSSSSSGASDAELEQAVEPVDLVEAEMSSFFAETACTPPVKVPSSGKPLQKVLSPGIEKPAGLEIIPLTTTSATTTATVSPNMLAGGFPAATVTITPLAGPQGTTNTSTPSPASTSASAPKKSSSSSSSTGSGHRKDATDRASSGKSEKKKKRKLDDGGGSGHLAMGPPNKLPFKSGESSPHRSGIGSSSSSSTSGSGSRSSPKHSSPVHHSSPKHAGTAGALGFHSPKHGSPSVSPKHPMHAGGGSSTGGGKPSMSALKSAAASGNSPSSKPSDPSGVGSGGSGGGSSGTNTSATGSSSKERDKDRSEKKALQFPGNSTTNSGGTSSSNTSNANSGSRSKASGLKLKQLDLAPGSSMTISMTGDSGSSSPIVAPMIDLTGSSGPAQQGSLPGTGMTTTASSMLQALQAAKNRKAPSSAGGGGGGGTVGGGGGLGGSLSAVIDKLKSAQSVDDDGGAVLVLPEMTITQQTTSSNALGVNIGSFGSLGGGTLKDTSKTSSGGLLASTGGSGGGTLANCVSSAAGIGAASTQPSSMTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSNKSSSSSGGGSSNKSGGSNKSGLKSGVSSGPASSKQQQQQQQQQQNHTTSFSGAFPSSTKSPHYSSSSSKAPFQKSNSFGSLSGTGSGGLKASKVSSPKSASNPASSSSSSSSSSSYSSSSSKSSKSSKSSSASSLAGAMLAGAVAGAGAGSGSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNSGGGSGGSGSAGASGAGDPGDGGSSNKSAQKDATVRKQKPNTSSSPAAQVSAGAGGPAPLRQFTTASSPSGDASARLLSDLLGAAAAKSASKGPGGGGIASVDGAGGSAALHPLLPNIVQKMFGSDGTLQSKSNSSDGSMFPSAGRASPGMLSGGGGGGGSSSRDGFRSGSAPGTPTATGSMVLPPFPSPISGSASNDADAGALMRPPSRPSSTISNHSHSSQDGTGNSTDTTTTNTPPGVNSMAAAAAAAAAASMMLMNAMSGAGAQSSATGGTIPLDGSSSTSTTQQLMMAALAAKSGGGGVLPSTASNLLNNHHLHHHASNLLGNLPSPASVSVHIVKSPAPSPLPFASPHSNASSGHGGAGAGGGSGGGGGVPGLDDDLMDEALIGIGSK
Length2123
PositionMiddle
OrganismAnopheles dirus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.291
Instability index53.01
Isoelectric point9.21
Molecular weight208858.85
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08004
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|    1999.26|     483|     491|     998|    1488|       1
---------------------------------------------------------------------------
  341-  641 (270.76/45.34)	...................................................................................................................................GGGAAAQPVYTPIEKHNSTSLPASFVLRLSKPMPIN.GAMMRAIRGIVG...GAVEQAGGDGGAG..SSSTG...LPGSLLALIAHHASGGSVKDLAKGLLVsLPDQYHCYHLTDNPALrGVMVSSipftepqhvpkiltylrqqvvFNQL...............................LASCIR......................................................................................................................................................................................................TNVP.P...........AAATAT.....A................STGALGSTGRPSAL.............QQLL..DGGAAHH.EPGLGGLLVFEvSALSCqyitvslmhPYEEslatvefdlanianiavriycGEGQATDQHTldriSGVLQRC.....MSIPVTlRALMKHWEEEHEQKFKPSVLGSavPSTNGGGPGGGGG
  649-  899 (266.13/44.07)	GSGTGGAGSSedtpMNGFNlSSLAGGGS....AAAAPSSGDG.GAGTPG.SNATGT.NSTTNGMNGGGGGVDTS...GLDFCDMLTDRNGG...REPPEPLAGGVAK....KRRMEDFckSPKSDSNLSAGGGGGVGEG.V.EM...AGTATSTTTTTRDGLVVTVGRSE........QQRtqQPPVGAPEEDTDGRVTTPAP...AGG...GVVDGKGSSL.....GGTTNT.SATTTITTTTTTSNA......TA.....................SAALKTDaillHLPDA......DLVKPVQSSSSSSLSS.LSSSSSV..AAA...........................................................................................................................................................................................................................................................................................................................................................................................................
  998- 1206 (233.54/42.02)	.........................................................................................................................................................................................................................................................................................................................................slgftgavvasgepperapsagtllleslefsptptdrpsvkrrrsssssssssssssssssssssssgasdaeleqavepvdlveaemssffaetacTPPVKV...PS......SGKPLQKVLSPGIEkpaGleiIPLT.......TTSATTTATVSPNMLAGGFPAATVTITPLAGPQGTTN....TSTPSP...........ASTSAS.....APKK..........SSSSSSSTGSGHRKDATDRASSGKSEKKKKRKLD..DGGGSGHLAMGPPNKLPFK.SGESS.........PHRS.....................GIGSSSSSST....SGSGSRS..SPKHSSPVH.HSSPKHAGTAGALGFHSPKHGS..PSVSPKHPMHAGG
 1207- 1699 (714.06/137.26)	GSSTGGGKPS....MSALK.SAAASGNS....PSSKPSDPSGVGSGGSG.GGSSGT.NTSATGSSSKERDKDRSEKKALQFPGNSTTNSGGTSSSNTSNANSGSRSKASglKLKQLDL..APGSSMTISMTGDSGSSSPIVAPMIDLTGSSGPAQQGSLPGTGMTTTASSMLQALQAAKNR..KAPSSAGGGGGGGTVGGGGG...LGGSLSAVIDKLKSAQSVDDDGGAVLV.LPEMTITQQTTSSNAL.GVNIGS.....................FGSLGGG....TLKDTSKTSSGGLLASTGGSGGGTLANCVSSAAGI..GAA.................................................................................................sTQPSSMtsaPSltaaltSGKASEYMVKPSSD...G...IKLTiqnkkgsNKSSSSSGGGSSNK.SGG......S.....NKSGLKS....GVSSGP...........ASSKQQ.....QQQQqqqqnhttsfSGAFPSSTKSPHYS.....SSSSKAPFQKSNSFGslSGTGSGGL..KASKVSSPK.SA.SN.........PASS.....................SSSSSSSSSY....SSSSSKSskSSKSSSA....SSLAGAMLAGAVAGAGAGSGS..ALVNPISIMKMLG
 1700- 2097 (514.77/95.05)	.YPTG....S....MGNME.GFAKSLDTkfqiPKLSARSNSGGGSGGSGsAGASGAgDPGDGGSSNKSAQKDATVRK..QKP........NTSSSPAAQVSAGAGGPAP...LRQFTT..AS......SPSGDA.................................SARLLSDLLGAAAA..KSASKGPGGGGIASVDGAGGsaaLHPLLPNIVQKM.....FGSDG..........TLQSKSNSSD....................................G....SMFPSAGRASPGML.SGGGGGGGS.....SSRDGFrsGSA.......................................................................................pgtptatgsmvLPPFPS...PI......SG................................SASNDADAGALMRPPSRPSSTISNHSHSSQDGTGNstdtTTTNTPpgvnsmaaaaaAAAAASmmlmnAMSG..........AGAQSSATGGTIPLDGSSSTSTTQQLMMAALAAK..SGGG.GVLPSTASNLL..N.NHHLH.........HHAS.....................NLL..............GNLP..SPA.SVSVHiVKSP....APSPLPFASP.HSN..AS.SGHGGAGAGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.48|      17|      19|      22|      38|       2
---------------------------------------------------------------------------
   22-   38 (32.24/ 9.50)	LMANGGSGGGAGGKGLG
   42-   58 (33.24/10.10)	IKPPGSIGGPGGGPGTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.64|      16|      18|     119|     134|       3
---------------------------------------------------------------------------
  119-  134 (27.82/21.89)	KSNLQKTLDSM..QYCIK
  138-  155 (21.81/15.35)	RQGLVERLDCLtrQLGLK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08004 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGGKGLGKSDIKPPGSIGGPGGGPGTGGGTTGKVLL
2) DTKFQIPKLSARSNSGGGSGGSGSAGASGAGDPGDGGSSNKSAQKDATVRKQKPNTSSSPAAQVSAGAGGPAPLRQFTTASSPSGDASARLLSDLLGAAAAKSASKGPGGGGIASVDGAGGSAALHPLLPNIVQKMFGSDGTLQSKSNSSDGSMFPSAGRASPGMLSGGGGGGGSSSRDGFRSGSAPGTPTATGSMVLPPFPSPISGSASNDADAGALMRPPSRPSSTISNHSHSSQDGTGNSTDTTTTNTPPGVNSMAAA
3) ETACTPPVKVPSSGKPLQKVLSPGIEKPAGLEIIPLTTTSATTTATVSPNMLAGGFPAATVTITPLAGPQGTTNTSTPSPASTSASAPKKSSSSSSSTGSGHRKDATDRASSGKSEKKKKRKLDDGGGSGHLAMGPPNKLPFKSGESSPHRSGIGSSSSSSTSGSGSRSSPKHSSPVHHSSPKHAGTAGALGFHSPKHGSPSVSPKHPMHAGGGSSTGGGKPSMSALKSAAASGNSPSSKPSDPSGVGSGGSGGGSSGTNTSATGSSSKERDKDRSEKKALQFPGNSTTNSGGTSSSNTSNANSGSRSKASGLKLKQLDLAPGSSMTISMTGDSGSSSPIVAPMIDLTGSSGPAQQGSLPGTGMTTTASSMLQALQAAKNRKAPSSAGGGGGGGTVGG
4) GFTGAVVASGEPPERAPSAGTLLLESLEFSPTPTDRPSVKRRRSSSSSSSSSSSSSSSSSSSSSSSGASDAELEQAVEPV
5) KHWEEEHEQKFKPSVLGSAVPSTNGGGPGGGGGGTGPDGTGSGTGGAGSSEDTPMNGFNLSSLAGGGSAAAAPSSGDGGAGTPGSNATGTNSTTNGMNGGGGGVDTSGLDFCDMLTDRNGGREPPEPLAGGVAKKRRMEDFCKSPKSDSNLSAGGGGGVGEGVEMAGTATSTTTTTRDGLVVTVGRSEQQRTQQPPVGAPEEDTDGRVTTPAPAGGGVVDGKGSSLGGTTNTSATTTITTTTTTSNATASAALKTD
6) KPSSDGIKLTIQNKKGSNKSSSSSGGGSSNKSGGSNKSGLKSGVSSGPASSKQQQQQQQQQQNHTTSFSGAFPSSTKSPHYSSSSSKAPFQKSNSFGSLSGTGSGGLKASKVSSPKSASNPASSSSSSSSSSSYSSSSSKSSKSSKSSSAS
7) MNAMSGAGAQSSATGGTIPLDGSSSTSTTQQLMMAALAAKS
8) SVSVHIVKSPAPSPLPFASPHSNASSGHGGAGAGGGSGGGGGVPGL
32
1716
994
902
609
1516
1988
2063
67
1976
1391
981
864
1666
2028
2108










Molecular Recognition Features






MoRF SequenceStartStop




1) AKKRRMEDF
2) EKKKKRKLD
3) KHAGTAGALGF
4) LKLKQLD
5) LSDLLGAAA
6) SALKSA
7) SMLQALQAAKNR
741
1109
1176
1306
1807
1218
1363
749
1117
1186
1312
1815
1223
1374