<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08004

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSSGTAAAVVGGVSGTLPALLMANGGSGGGAGGKGLGKSDIKPPGSIGGPGGGPGTGGGTTGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFPEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSAAHYPDVQSQLAKAPLGLVQKRRGGHPMRLTYFVAPYELLDLGARTLNALSAERIAAERIGCSVAVVLEAASANKLQIQPLVVVSGGGAAAQPVYTPIEKHNSTSLPASFVLRLSKPMPINGAMMRAIRGIVGGAVEQAGGDGGAGSSSTGLPGSLLALIAHHASGGSVKDLAKGLLVSLPDQYHCYHLTDNPALRGVMVSSIPFTEPQHVPKILTYLRQQVVFNQLLASCIRTNVPPAAATATASTGALGSTGRPSALQQLLDGGAAHHEPGLGGLLVFEVSALSCQYITVSLMHPYEESLATVEFDLANIANIAVRIYCGEGQATDQHTLDRISGVLQRCMSIPVTLRALMKHWEEEHEQKFKPSVLGSAVPSTNGGGPGGGGGGTGPDGTGSGTGGAGSSEDTPMNGFNLSSLAGGGSAAAAPSSGDGGAGTPGSNATGTNSTTNGMNGGGGGVDTSGLDFCDMLTDRNGGREPPEPLAGGVAKKRRMEDFCKSPKSDSNLSAGGGGGVGEGVEMAGTATSTTTTTRDGLVVTVGRSEQQRTQQPPVGAPEEDTDGRVTTPAPAGGGVVDGKGSSLGGTTNTSATTTITTTTTTSNATASAALKTDAILLHLPDADLVKPVQSSSSSSLSSLSSSSSVAAASLGFTGAVVASGEPPERAPSAGTLLLESLEFSPTPTDRPSVKRRRSSSSSSSSSSSSSSSSSSSSSSSGASDAELEQAVEPVDLVEAEMSSFFAETACTPPVKVPSSGKPLQKVLSPGIEKPAGLEIIPLTTTSATTTATVSPNMLAGGFPAATVTITPLAGPQGTTNTSTPSPASTSASAPKKSSSSSSSTGSGHRKDATDRASSGKSEKKKKRKLDDGGGSGHLAMGPPNKLPFKSGESSPHRSGIGSSSSSSTSGSGSRSSPKHSSPVHHSSPKHAGTAGALGFHSPKHGSPSVSPKHPMHAGGGSSTGGGKPSMSALKSAAASGNSPSSKPSDPSGVGSGGSGGGSSGTNTSATGSSSKERDKDRSEKKALQFPGNSTTNSGGTSSSNTSNANSGSRSKASGLKLKQLDLAPGSSMTISMTGDSGSSSPIVAPMIDLTGSSGPAQQGSLPGTGMTTTASSMLQALQAAKNRKAPSSAGGGGGGGTVGGGGGLGGSLSAVIDKLKSAQSVDDDGGAVLVLPEMTITQQTTSSNALGVNIGSFGSLGGGTLKDTSKTSSGGLLASTGGSGGGTLANCVSSAAGIGAASTQPSSMTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSNKSSSSSGGGSSNKSGGSNKSGLKSGVSSGPASSKQQQQQQQQQQNHTTSFSGAFPSSTKSPHYSSSSSKAPFQKSNSFGSLSGTGSGGLKASKVSSPKSASNPASSSSSSSSSSSYSSSSSKSSKSSKSSSASSLAGAMLAGAVAGAGAGSGSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNSGGGSGGSGSAGASGAGDPGDGGSSNKSAQKDATVRKQKPNTSSSPAAQVSAGAGGPAPLRQFTTASSPSGDASARLLSDLLGAAAAKSASKGPGGGGIASVDGAGGSAALHPLLPNIVQKMFGSDGTLQSKSNSSDGSMFPSAGRASPGMLSGGGGGGGSSSRDGFRSGSAPGTPTATGSMVLPPFPSPISGSASNDADAGALMRPPSRPSSTISNHSHSSQDGTGNSTDTTTTNTPPGVNSMAAAAAAAAAASMMLMNAMSGAGAQSSATGGTIPLDGSSSTSTTQQLMMAALAAKSGGGGVLPSTASNLLNNHHLHHHASNLLGNLPSPASVSVHIVKSPAPSPLPFASPHSNASSGHGGAGAGGGSGGGGGVPGLDDDLMDEALIGIGSK
Length2123
PositionMiddle
OrganismAnopheles dirus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.291
Instability index53.01
Isoelectric point9.21
Molecular weight208858.85
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08004
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|    1999.26|     483|     491|     998|    1488|       1
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  341-  641 (270.76/45.34)	...................................................................................................................................GGGAAAQPVYTPIEKHNSTSLPASFVLRLSKPMPIN.GAMMRAIRGIVG...GAVEQAGGDGGAG..SSSTG...LPGSLLALIAHHASGGSVKDLAKGLLVsLPDQYHCYHLTDNPALrGVMVSSipftepqhvpkiltylrqqvvFNQL...............................LASCIR......................................................................................................................................................................................................TNVP.P...........AAATAT.....A................STGALGSTGRPSAL.............QQLL..DGGAAHH.EPGLGGLLVFEvSALSCqyitvslmhPYEEslatvefdlanianiavriycGEGQATDQHTldriSGVLQRC.....MSIPVTlRALMKHWEEEHEQKFKPSVLGSavPSTNGGGPGGGGG
  649-  899 (266.13/44.07)	GSGTGGAGSSedtpMNGFNlSSLAGGGS....AAAAPSSGDG.GAGTPG.SNATGT.NSTTNGMNGGGGGVDTS...GLDFCDMLTDRNGG...REPPEPLAGGVAK....KRRMEDFckSPKSDSNLSAGGGGGVGEG.V.EM...AGTATSTTTTTRDGLVVTVGRSE........QQRtqQPPVGAPEEDTDGRVTTPAP...AGG...GVVDGKGSSL.....GGTTNT.SATTTITTTTTTSNA......TA.....................SAALKTDaillHLPDA......DLVKPVQSSSSSSLSS.LSSSSSV..AAA...........................................................................................................................................................................................................................................................................................................................................................................................................
  998- 1206 (233.54/42.02)	.........................................................................................................................................................................................................................................................................................................................................slgftgavvasgepperapsagtllleslefsptptdrpsvkrrrsssssssssssssssssssssssgasdaeleqavepvdlveaemssffaetacTPPVKV...PS......SGKPLQKVLSPGIEkpaGleiIPLT.......TTSATTTATVSPNMLAGGFPAATVTITPLAGPQGTTN....TSTPSP...........ASTSAS.....APKK..........SSSSSSSTGSGHRKDATDRASSGKSEKKKKRKLD..DGGGSGHLAMGPPNKLPFK.SGESS.........PHRS.....................GIGSSSSSST....SGSGSRS..SPKHSSPVH.HSSPKHAGTAGALGFHSPKHGS..PSVSPKHPMHAGG
 1207- 1699 (714.06/137.26)	GSSTGGGKPS....MSALK.SAAASGNS....PSSKPSDPSGVGSGGSG.GGSSGT.NTSATGSSSKERDKDRSEKKALQFPGNSTTNSGGTSSSNTSNANSGSRSKASglKLKQLDL..APGSSMTISMTGDSGSSSPIVAPMIDLTGSSGPAQQGSLPGTGMTTTASSMLQALQAAKNR..KAPSSAGGGGGGGTVGGGGG...LGGSLSAVIDKLKSAQSVDDDGGAVLV.LPEMTITQQTTSSNAL.GVNIGS.....................FGSLGGG....TLKDTSKTSSGGLLASTGGSGGGTLANCVSSAAGI..GAA.................................................................................................sTQPSSMtsaPSltaaltSGKASEYMVKPSSD...G...IKLTiqnkkgsNKSSSSSGGGSSNK.SGG......S.....NKSGLKS....GVSSGP...........ASSKQQ.....QQQQqqqqnhttsfSGAFPSSTKSPHYS.....SSSSKAPFQKSNSFGslSGTGSGGL..KASKVSSPK.SA.SN.........PASS.....................SSSSSSSSSY....SSSSSKSskSSKSSSA....SSLAGAMLAGAVAGAGAGSGS..ALVNPISIMKMLG
 1700- 2097 (514.77/95.05)	.YPTG....S....MGNME.GFAKSLDTkfqiPKLSARSNSGGGSGGSGsAGASGAgDPGDGGSSNKSAQKDATVRK..QKP........NTSSSPAAQVSAGAGGPAP...LRQFTT..AS......SPSGDA.................................SARLLSDLLGAAAA..KSASKGPGGGGIASVDGAGGsaaLHPLLPNIVQKM.....FGSDG..........TLQSKSNSSD....................................G....SMFPSAGRASPGML.SGGGGGGGS.....SSRDGFrsGSA.......................................................................................pgtptatgsmvLPPFPS...PI......SG................................SASNDADAGALMRPPSRPSSTISNHSHSSQDGTGNstdtTTTNTPpgvnsmaaaaaAAAAASmmlmnAMSG..........AGAQSSATGGTIPLDGSSSTSTTQQLMMAALAAK..SGGG.GVLPSTASNLL..N.NHHLH.........HHAS.....................NLL..............GNLP..SPA.SVSVHiVKSP....APSPLPFASP.HSN..AS.SGHGGAGAGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.48|      17|      19|      22|      38|       2
---------------------------------------------------------------------------
   22-   38 (32.24/ 9.50)	LMANGGSGGGAGGKGLG
   42-   58 (33.24/10.10)	IKPPGSIGGPGGGPGTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.64|      16|      18|     119|     134|       3
---------------------------------------------------------------------------
  119-  134 (27.82/21.89)	KSNLQKTLDSM..QYCIK
  138-  155 (21.81/15.35)	RQGLVERLDCLtrQLGLK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08004 with Med1 domain of Kingdom Metazoa
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