<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08003

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMNPGRLGLAQTAQENPLWISWHDSNWIPVLNPGNVMDYFSEKSNPFYDRTCNNEIVRMQRQSLELLNNMTGVEYIPLHVQDPILYVIRKQHRHSPTEATPMADYYIIAGTVYQAPDLANVFNSRILSTVHHLQTAFDEASSYSRYHPSKGYSWDFSSNKAIAEKTKTQTKKEAPVKEEPSSIFQRQRVDMLLGDLLRKFPLPLPQITNNPAGGNNPADMNNANNNHSGAAGENDHSGADHAMIKQEPSDSIGVAGRGGNSDAPPEKKMKL
Length270
PositionHead
OrganismAnopheles dirus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.08
Grand average of hydropathy-0.710
Instability index42.87
Isoelectric point6.36
Molecular weight30184.39
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08003
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.04|      18|      31|       1|      18|       1
---------------------------------------------------------------------------
    1-   18 (33.81/18.26)	MNPGRLGLAQTAQENPLW
   30-   47 (34.22/18.55)	LNPGNVMDYFSEKSNPFY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.60|      30|      31|      55|      84|       2
---------------------------------------------------------------------------
   55-   84 (52.41/28.84)	IVRMQ.RQSLELLNNMTGVEYIPLHV.QDPIL
   86-  117 (44.19/23.49)	VIRKQhRHSPTEATPMADYYIIAGTVyQAPDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08003 with Med6 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PLPQITNNPAGGNNPADMNNANNNHSGAAGENDHSGADHAMIKQEPSDSIGVAGRGGNSDAPPEKKMKL
202
270










Molecular Recognition Features






MoRF SequenceStartStop




1) APPEKKMKL
2) HSGADHAMIKQEPSDSIGVAGRG
262
235
270
257