<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07999
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MQREEKQLDMLLEAVLNRLNDLKHSIGVMIHRLETEYETINWPTFLDNFALISSHLTGLMKILSTEIGTPLRNLTVLPLMLTPERDEALLQLTEGRVPIFSHDLAPDYLRTKPDPGAESRQAAHEAKANNLTVEASIKQVAQYNKVISHVWDIISKAKEDWENESSTRPGIQQTSSMADTQALVAAVGLGNGLTAPAGPGVMIPPAIRQGSPMSAVSPSGNAPMGKMPSGIKTNIKSANQVHPYR |
Length | 245 |
Position | Head |
Organism | Anopheles dirus |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae>
Anophelinae> Anopheles.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.287 |
Instability index | 37.16 |
Isoelectric point | 6.17 |
Molecular weight | 26789.37 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP07999
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 63.64| 23| 28| 33| 60| 1
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27- 57 (27.97/40.73) GVMihrLETEyetINWPtfLDNFALISSHLT
58- 82 (35.68/28.35) GLM.kiLSTE...IGTP..LRNLTVLPLMLT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 63.42| 22| 28| 177| 201| 2
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169- 198 (27.73/20.69) PGIqqtssMADTQALVAAVGLGNgltAPAG
199- 225 (35.69/18.84) PGVmippaIRQGSPMSAVSPSGN...APMG
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