<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07996

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSAELRIVKLFEEVLEDKNIVPSFDEEEQRKKTEEGYKKIGALFGAMTPEVKEASIRSYLGYVASVNHQNRVHNYLQVMNRMVALNIIPAKLLCDQLMCSDKLVYKNPCFWIEAFQLIRKVIGGVDYKGVREIMKCCKEKALSFPANVSVNILPQLLELVELIEHIFNRNACLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSSMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDEELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMEYSEKEGAQGQNTATGSGMGEHDNDQSHTQWIWLHLSSQLIYFVLFQFATFQNIVNTLHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKEPLPVPDYNNPYCTHQMAPTCIWIHLMKRAQTENYNINRPIPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMVGGGVQPLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYVSEPKPPGNIVSGESEELNRALILTLARSMHITGTGNDPQSSAWCKDLLQNIMLNTPHAWPQHTLFCFPPVLNEFFIQHNIPKESKQLLKKTVDEEYRNWASMTNENDIIAHFGMTVNPPLFLCLVFKMIIETDGISPVAYKILERIGARALSTHLRKMCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIVTIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTTEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPTLPVYFGNVCLRFLPVLDIIVHRYLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWALTEAYQAYMMTKESDNVNWVPELSYYVNLVRRMQDTMDGKNIFSGTDWRFNEFPNPPAHALYVTCVELLGLPVGPSVVANSIIDVLVKGYTVVPNSVVHSWTNTIGLIMAALPEAYWSVIYERMQEALNSKAMKEWSYRQSPFVMFNFKVVKEAMLDRSYVTVLAIVHSIFHHFGIGQLATITESIKEKLKPLVHTEYQLIYLCHVVGPFLNRLSTERARAVSDITLMLYELLEQVDKAQPTQPLRYMDPICDLLYHIKYMFVGDTMKTELEAIIRRLRPALQMRLRFITRLNVDEIGVDQNATGAQGVAANAAPGAPATGSTAPGTGTSGIVAPGPGGNVTAGAGPQQTQVGAGGVAGSGGGVSNPNVALQQQLQQQQQQMGQGMQTHH
Length1445
PositionTail
OrganismAnopheles dirus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.116
Instability index43.16
Isoelectric point7.47
Molecular weight164416.39
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07996
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1086.78|     309|     328|     672|     999|       1
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  409-  670 (243.38/166.10)	.............................................................LYDILY..PE...KEP......LPvPDYNNPYCTHQMAPTCiwI..HLMKRAQTE.NYNiNRpipIALRLHFEYLQHLAMpSNNPT...LFmgseyrfalL.CN.AYS..TQTDYFSRPMQALIDTIlgnsknpqanmvggG...................VQPLPTaplSMRVL.DSLTIHSKMSLIHSIVMHMIKQAQN...KS..........SIP....................NGNNMAPALVETYSRLLVYTEIESlGIKGFLGQLLPQVFKSQAWgilytllemfsyrmHHIHSHYRVQLLTHLHSLAS......VPHTNqmqLHSC..VEST.......ALR............................
  677-  999 (511.99/362.01)	SV.EVQAQLSRYVSEPKPPGNIVSGESEELNRALILTlarsmhITGTGNDPQSSAWC.KDLLQNIMLNTPH...AWPqhtlfcFP.PVLNEFFIQHNIPKES..K..QLLKKTVDE.EYR.NW...ASMTNENDIIAHFGM.TVNPP...LF.........L.CL.VFKMIIETDGISPVAYKILERI..............G...................ARALST...HLRKMCDYLLFEVANSGGGAHVNKCVDTINDmiWKY..........NIV...TIDR...LVLCLILRTLDGNEAQVSFYIIQLLLLKTTEFRN.RVQEFITINSPEHWKQNNW..............HERHLAFHQKFPEKFAPDES......VSHPT...LPVY..FGNV.......CLRFL.PVLDIIVH.RYLEVPTQLSKTLDVI
 1005- 1329 (331.40/209.89)	SLyKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGT......VVGSLKDVRPENWAlTEAYQAYMMTKESdnvNW.....................VPELS..YyvNLVRRMQDTmDGK.NI...FSGT..DWRFNEFP....NPPahaLY.........VtCVeLLGLPV...GPSVVANSIIDVL............vkGytvvpnsvvhswtntigliMAALPE...AYWSVIYERMQEALNSKAMKE............WSYrqspfvmfnfKVVkeaMLDRsyvTVLAIVHSIFH......HFGIGQLATI.TESIKE.KLKPLV......H....................TEYQLIYLCHVVGPFLNRLSteraraVSDIT...LMLYelLEQVdkaqptqPLRYMdPICDLLYHiKYMFVGDTMKTELEAI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     328.78|     110|     150|       7|     156|       2
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    7-  136 (158.34/175.12)	IVKLFEEVLeDKN..IVPSFDEEEQRKKTEegYKKIGALFGAMTPE.....VKEASIRSYLGY...VASVNHQNRVHNylqvmnrmvalnIIPAKLLCDQLMCS..DKLVYKNPCFWIEAfQLIRKVIGGvDYKgvREiMKC
  159-  281 (170.44/100.29)	LVELIEHIF.NRNacLLPAYFIINEIKKTD..YQNMHWRVSNLTANfieefVSVAQMLSIIGHssmLPIVEHSSYADN...........lIIPWKLDPDTLKLSlrGNLPYDEELLQPQA.RLLRFVLQQ.PYS..RD.MVC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.67|      13|      45|    1353|    1365|       4
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 1353- 1365 (23.78/14.36)	GVDQNATGAQGVA
 1401- 1413 (24.89/15.36)	GPQQTQVGAGGVA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07996 with Med23 domain of Kingdom Metazoa
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