<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07985

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPQPLEQGGAVANFIPTGQEMAQRQNLIPLGRLIDFIIQRTYHELTVLAELLPRKTDMDRKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMGFLDKQSMLFIDTADMLSRVARETLVHARLPNFHIPAAVEILTTGSYSRLPSVIRDRIVPPDPITPAEKRQTLQRLNQVIQHRLVTGSLLPQLRKFRIENGRVTFKVDHEFEVSLTVMGDAPTVPWRLLDIDFLVEDKETGDGKALVHPLQVNYIHQLIQGRIVDCTDALAEVYTCLHYFCQSLQLEVLYTQTLRLIRDRLDDHIHVDEYVVGSRLTVSYWRELTNKDPKSELGYRLTIQTDPNDAAKQLAILHVPSIGNKEADIADRAVRSDLLSMERLLVHTVYVRSLARLNDVKAELQLFLKDVEYHIQGTPAMLTVPVLNPCLRAEHIYITVDTHTGMLRCHVPKHLDCPIMPEMQHALNNDWSKLQHLISELRYWITQRRCEKTLQHLPAATQDRLPLIYPQNHPIARMGPHKVFIQLYRHANVILIVELKEKTSCPNEMTYTFYLVLVKPSSVEEGQSQDASSSSAAGGQQSQSATTGGQASGSEVTAAMPKMYLRVLSMIEFDTFVATHGPGTYIDDPASYTSSNGVAGTSKRKLSPLDNALSAVGPPMKQQKTIYPAYFIPELAHVVAMCDEKLPFVTLAKEFTMRKIPHGGLQVEANATSLVLKLLTLPQPKPPQAPPTAAPQQQPAASGSDPKATAAAASAAANEPKTVHVPPIDKQVWNALLKRLLSVSVRAQVNKSNQTRLWTIELVFYGSPLPSLHHKEQGMRRAVYLQYEMQPVESVSKVVDQLLSDWSKIVYLYTLVHEFREQFNNEKYNLPSMVAIKSYSYTNLLLAYGPNREVSVSICWDTEAKEFRLVFTGGNSAINAHSMMRDQLQAHLNHNYSLAQIVHMLHETYQPLGSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRFRGGGLCTIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVFRRRSQSEDDNPPSPVTLEDPSGGTGGGGGGGGGGGTGAGTGGGGNNGGGGGGGSNTFLGGGGSGMRGPQSPRDPGLRFAAPLTPPTTSNPHTPASPHPIGGGGGGGGGGGGGAGTGGSGGAGGGAGGGQGGQGQQPGSHMNNFNMTSPPASHMPHPSPSGGLMPSSPLNAQPSPMAAHSPGPSSLPYMQSHTEGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYASRVLPARSWAGAIPTTLTYEALDTLCRATPHPQKEVPGPELSPLERFLGSVFMRRQLQRIVHQEESLMSITSNEPGVVVFKADCLQYQVFLNPNHMQSLHLKVDQLQMGPMMDGKPPYQWAAQDLQILEQFFDQRVAAPPYRPAVMTSFTRMLNLPAKVLKDFIQIMRLDLMPELVQGNKWNVQFVLRVPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMEWKDAVTMLLPMVYDMNMNHTTLAERREPMPPQLTSAVSAHLRRFSESSMLLPDECSLFPAVHDLLVTLTLPNEPHAPGQMQMQLGGVMQPGGGPGGPGGPGGPMGGQIGGPSPQVVPQVGSSPGPMMHSPMQQMGGVGPQPGGYGGMVGGPGGGPQAGGPGGGGGPGGPN
Length1673
PositionTail
OrganismAnopheles dirus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy-0.261
Instability index52.20
Isoelectric point8.51
Molecular weight181805.18
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07985
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     357.86|      57|      57|    1083|    1139|       2
---------------------------------------------------------------------------
 1048- 1111 (76.97/24.72)	EDDN......PP.SPVTLEDPSG..............gtgggggggggggtgagtgGG.GNNGGGGGGG..SNTFLGGGGSGMRGPQS
 1112- 1160 (89.96/30.10)	PRDPGLRFAAPL.TPPTTSNPHTPASPH........P..................iGG.GG.GGGGGGG..GGA..GTGGSG......
 1199- 1225 (43.61/10.90)	P.SGGLMPSSPLnAQPSPMAAHSP............................................................GPSS
 1574- 1622 (55.76/15.93)	.................PNEPHAPGQMQmqlggvmqP...................GG.GPGGPGGPGGpmGGQI..GGPSPQVVPQV
 1623- 1671 (91.55/30.76)	GSSPGPMMHSPM.QQ...MGGVGP...Q........P...................GGyGGMVGGPGGG..PQA.GGPGGGG..GPGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.82|      15|      17|    1261|    1275|       3
---------------------------------------------------------------------------
 1261- 1275 (29.51/16.77)	PGQSPEHKVQTSHHY
 1281- 1295 (27.31/14.91)	PARSWAGAIPTTLTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     180.74|      41|      49|    1415|    1457|       4
---------------------------------------------------------------------------
 1369- 1396 (41.91/22.59)	.....PNHMQS....LHL..KV..DQLQMgpM.MDGKP....PYQW
 1415- 1457 (73.56/51.64)	PPY.RPAVMTSFTRMLNLPAKVLKDFIQI..MRLDLMPELvqGNKW
 1466- 1504 (65.26/39.64)	PPSaTPIVPVGTTTILSHRQKILF.FIQI..TRVPYLPNM....EW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.48|      23|      59|    1173|    1198|       5
---------------------------------------------------------------------------
 1173- 1198 (43.94/29.40)	QGQQPGShmnNFNMTSPPASH......MPHPS
 1230- 1258 (38.54/17.92)	QSHTEGS...PFAALSPAASNwpgspgMPRPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.15|      53|     547|     761|     823|       8
---------------------------------------------------------------------------
  761-  823 (86.77/82.40)	PPIDKQVWN...ALLKRLL.SVSVRAQVNKsnqtrlwtieLVFYGSPLPSLHHKEQG..MRRAVYLQYE
 1306- 1364 (82.39/57.07)	PHPQKEVPGpelSPLERFLgSVFMRRQLQR..........IVHQEESLMSITSNEPGvvVFKADCLQYQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07985 with Med14 domain of Kingdom Metazoa
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