Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MFNNYGNTMATDPFRKGEQYSPKSSPRAGGAGGRSPVVARQDSSGTLKTTIQLGKNPSILHSGPFYLMKEPPGEGELTGATNLMAHYGLEHSYSKFSGKKVKEQLSSFLPNLPGVIDGPGHLDNSSLRSVIEKPPIVGKELLPLTSVQLAGFRLHPGPLPEQYKHLKTAPTRKHKNKHKKHKHKDGVAPPEQSALEAAGLDTHEKKHKKQKRHEDDKERKKRKKEKKRKKQRHSPEHPADCLPSPHQRRTILVAQSKRR |
Length | 259 |
Position | Head |
Organism | Anopheles culicifacies |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles> culicifacies species complex. |
Aromaticity | 0.05 |
Grand average of hydropathy | -1.118 |
Instability index | 65.82 |
Isoelectric point | 10.14 |
Molecular weight | 28907.71 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP07982 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 98.54| 25| 27| 160| 185| 1 --------------------------------------------------------------------------- 160- 182 (31.60/19.89) .......PEQyKHL.KTAPTRKHKNKHKKHK 183- 211 (39.34/20.40) HKDgvapPEQ.SAL.EAAGLDTHEKKHKKQK 213- 232 (27.60/12.28) HED...........dKERKKRKKEKKRKKQR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 87.56| 24| 43| 17| 40| 2 --------------------------------------------------------------------------- 17- 40 (42.84/21.46) GEQYSPKSSPRAGGAGGRSPVVAR 63- 86 (44.71/22.67) GPFYLMKEPPGEGELTGATNLMAH --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) LPSPHQRRTILVAQSKR 2) RHEDDKERKKRKKEKKRKKQRHSPEH 3) YKHLKTAPTRKHKNKHKKHKHK | 242 212 163 | 258 237 184 |
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