<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07981

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAEAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIGRWFVHPSSNSEGVFGKSSHHASFSFTFFVHGDSTVCTSMDIREHPPVRLLTMKHLEEAQQAQQASPNAGTNGGPASPTVSGVNGGTSTTPGSPGGGAGGAANGSATINSPDAIEPREVILAPFGLAGTLTGQSYKTSDPHVQKMLDDWSAFYPISNKLSSMEDGSDNVPPMVEILVGKLKMRYPTKYVLVADMDDWTSANDTRSNSSSNSNSSSSSNHNNSNQTATPATAIPSIAATVLSRANNATERSSGPINTTSNQPATGTSIGSSNPPPAARNKDTPHESSSVAASPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHASPSPSPMSSSSANSSTTAASNGSQTTPGSGVTIKTEPKDTSSSGGNGSNTATSSSSSSNPSSGGGDENSSGAANGVDANGNSSVWEISDPTVKVSCCCIKCCKRPPSSSSSTSTSSSSASSSSKQQQQQQHTIGVAVSSSCSLSATASLANLYTSNPSPKSSYTITYPGTGGGGNNRGEKSTHGHQYHHYHHHHGVGGQSVKDHHHHHHHRPQRIAFHKRPAQEALFRPGTKPISLSAAATALAAAVAAAATAAGSSSTAANAADTSPGAVSSGDSAADSLELADSCLRSNQNCATNSNSSSGGTNSTGAAAGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPSTPCLDHLDKNTPAPTPTDQHDSKSINLSPYHTPSHPGGGGNGGGGSSTGNSTDAQQQQSQSNSNMGNSSSSSSSGSNSSSNSSSLNALKTSPRSSTLSSGIGSLKVRSESSLGAGSSMGSGGGVPMTPSIHSVYSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYEVLQSEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAMEENRLVKKIRNLDLYANEHSRTMTTSYGVSSTGMPGSNSVGTVGANGMLMKVGTTAGDGADTLSETLGGHNGGGGAAGACDNGASNNGGCQSLLGHGQIKMELGCDGSGGVGGREGATGVAGSGMGSANGTPDRNGPSSGNGDGALLGEHEIKKEKEEKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSCSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGIAIDTLVDMQMSISSGTGSGTGTGPNLPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQLIIPQIPTSTCTNLVYKSTRQKQKEQAAAEREKQKLREQAEREREQQQQQDQQQNSQSDSNNAQSTGASGTSGGGIGGPAGGVGLGLLPIIKQELGNLTIPQPLSTPNSLLGGLNNMNGSMNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGSGAGMLSPSPAGAGTSGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAAAGSPNPMGSLNFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQFPLDGVDTGGPGSNRGPMTPSSTGGGPLGTTVNPPLSSTGGVGCASGVGTNGGPISRSTNIETNALLVNILLYDTALNIFRDHNFKSCTLCVCNAGTKCVGNIRGADSGLYLALPGTNWMDSVTAPAETASGSGAGAAGGRSKASALAHLGLSGSSSSSSAFGGMLGSPAVGSNSDKTITINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKKSSFNSIHRAVNRYRGALFGRGSESGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQSTSGSSGALVKGGTLRGVMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALQYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGTSSTSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSSSSSASSASVSGGAPGSSSMGSGSMNQPGGNSMGQNRNDGPGQSPMPPPPPSTPDSSQPGDKGPNTPKFDHDAENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGSDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMTHSRPSSPSQFEGNQQSPDEGGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPDWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2780
PositionMiddle
OrganismAnopheles culicifacies
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles> culicifacies species complex.
Aromaticity0.05
Grand average of hydropathy-0.499
Instability index54.99
Isoelectric point6.21
Molecular weight291816.04
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07981
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     169.22|      48|      51|     648|     695|       2
---------------------------------------------------------------------------
  282-  331 (37.38/ 6.13)	LSRANNATERSSGP.....INTTSNQPATGTSI.GS.SNPPPAArnkDTPHESSSV.A
  682-  730 (48.08/10.29)	RSNQNCATNSNSSS....gGTNSTGAAAGSTTPyGGPPS..YCR...NPMSIGDSHpL
  840-  886 (43.98/ 8.70)	QSNSNMGNSSSSSSsgsnsSSNSSSLNALKTSP.RS.STLSSGI...GSLK......V
  887-  926 (39.79/ 7.07)	R........SESSL...gaGSSMGSGGGVPMTP..SIHSVYSSA...HQTAMANN..L
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.56|      31|      32|    1473|    1503|       3
---------------------------------------------------------------------------
 1473- 1498 (41.90/11.95)	......GMLS.P..SPAGAGTSGGLFHPGMGGIPV
 1519- 1547 (35.20/ 8.52)	PTPQGsCPLPyP..SPLG.GAAAGSPNP.MGSL..
 2170- 2200 (42.47/12.24)	NRNDG.PGQS.PmpPP.PPSTPDS.SQPGDKGPNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     148.34|      27|      33|     397|     423|       4
---------------------------------------------------------------------------
  397-  423 (47.23/14.92)	PSPMSSSSANSS..................TTAASNGS......QTTPGSG
  430-  456 (40.38/11.51)	PKDTSSSGGNGS..................NTATSSSS......SSNPSSG
  498-  529 (29.43/ 6.05)	P.PSSSSSTSTS..................SSSASSSSkqqqqqQHTIGVA
 1232- 1274 (31.31/ 6.99)	PHPNSSPGGGGClsdggiaidtlvdmqmsiSSGTGSGT......GTGPN..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.15|      16|      33|     732|     747|       5
---------------------------------------------------------------------------
  732-  747 (24.44/ 6.25)	SEGSPASAAPSPMQPS
  765-  780 (25.65/ 7.04)	SPHPPASNNPRSVQPS
 1436- 1451 (26.06/ 7.31)	SMNHPYSNPPSQGAQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.23|      33|      33|    1651|    1683|       6
---------------------------------------------------------------------------
 1637- 1660 (37.54/22.45)	I.SRSTNI.ET......NA...LLVNILLYDTALN
 1661- 1693 (60.81/42.33)	I.FRDHNF.KSCTLCVCNAGTKCVGNIRGADSGLY
 1694- 1718 (20.89/ 8.22)	LaLPGTNWmDSVTAPAETASGSGAG..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.32|      12|      16|     573|     587|       7
---------------------------------------------------------------------------
  573-  587 (19.51/24.63)	KSTHGHqyHHyHHHH
  592-  603 (27.81/17.42)	QSVKDH..HH.HHHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.35|      23|      24|    1053|    1075|       8
---------------------------------------------------------------------------
 1053- 1075 (47.21/16.96)	LGGHNGGGGAAGACD.NGASNNGG
 1079- 1099 (35.21/10.67)	LLGH.GQIKMELGCD..GSGGVGG
 1106- 1128 (33.93/10.00)	VAG.SGMGSANGTPDrNGPSSGNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.51|      12|      22|    1183|    1203|       9
---------------------------------------------------------------------------
 1185- 1196 (23.74/ 6.96)	SNKSCSGSGGFS
 1205- 1216 (22.77/13.87)	SNHHSVNSGMLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.53|      17|      22|    1279|    1300|      11
---------------------------------------------------------------------------
 1279- 1300 (30.09/28.69)	GSPQEEPIDDwsfvfLPPP.ICP
 1303- 1320 (27.44/12.66)	GSSKYAPLPS.....LPSQlIIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     233.56|      73|     202|    2423|    2509|      12
---------------------------------------------------------------------------
 2423- 2509 (104.20/92.68)	PNRGRRKRASARRyGLQKLMDFILGLISQtvQPwrLVVGR.IGRIGHGELKGWSWlLSKPnlqraskHLKDICEQC..SLMHpIAVPSIL
 2634- 2709 (129.35/72.74)	PDEGGSKGAGSRD.GYGSQDSEEVGLVLQ..QP..LAIGYlVSTAPTGRMPDWFW.SSCP.......HMENVCPVFlrTALH.LHSPTIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.66|      16|     202|    1874|    1889|      14
---------------------------------------------------------------------------
 1874- 1889 (29.58/15.55)	MDVDQQQ..STSGSSGAL
 2077- 2094 (25.08/11.77)	MGVDQQRknGTSSTSSGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.63|      25|      28|    1775|    1800|      15
---------------------------------------------------------------------------
 1771- 1796 (42.96/40.41)	GYLDEDPIDCqCGFS..AVVNRRMA....HRA
 1797- 1827 (34.67/25.52)	GLFYEDEMEI.TGMAedPAVHKKSSfnsiHRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.44|      10|     202|    1217|    1230|      16
---------------------------------------------------------------------------
 1217- 1230 (14.65/16.50)	PKELSqmfpTPPSL
 1417- 1426 (20.79/ 9.05)	PQPLS....TPNSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.81|      25|     202|     798|     822|      17
---------------------------------------------------------------------------
  340-  365 (40.93/18.40)	QRNHHKSMMTPPLTVPESPSNDlGNP
  798-  822 (49.88/24.51)	DQHDSKSINLSPYHTPSHPGGG.GNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.20|      13|      26|    1144|    1156|      19
---------------------------------------------------------------------------
 1144- 1156 (22.73/11.84)	EKGSIFLTDQDLQ
 1167- 1179 (26.47/15.14)	DDGGPFNDDPDLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.02|      18|      26|     136|     153|      20
---------------------------------------------------------------------------
  136-  153 (34.64/15.75)	PGGGAGGAANGSATINSP
  165-  182 (32.38/14.15)	PFGLAGTLTGQSYKTSDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.37|      20|      24|     628|     649|      21
---------------------------------------------------------------------------
  630-  649 (30.62/15.63)	SAAATAL...AAAVAAAATAAGS
  651-  673 (28.75/ 9.11)	STAANAAdtsPGAVSSGDSAADS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.95|      43|     491|    2212|    2261|      29
---------------------------------------------------------------------------
 2212- 2261 (66.89/46.17)	QLNTSSA.SPADGmRIDDDgkdpphIVLYIVEPFTCGS....DSPDVERLACLSL
 2717- 2764 (68.06/40.20)	QQNQSSTeHPLDS.NITAD......VLRYVLEGYNLLSwlamDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.64|      12|     230|    1388|    1400|      33
---------------------------------------------------------------------------
 1388- 1400 (20.55/14.45)	SGGGIGGpAGGVG
 1620- 1631 (25.09/12.24)	STGGVGC.ASGVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.19|      28|    1320|     458|     487|      35
---------------------------------------------------------------------------
  458-  487 (44.00/20.00)	GDENSSGAANGVdaNGNSSVWEISDPTVKV
 1736- 1763 (49.19/18.36)	GSSSSSSAFGGM..LGSPAVGSNSDKTITI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.67|      14|      19|    1337|    1350|      37
---------------------------------------------------------------------------
 1337- 1350 (21.23/17.01)	QKQKEQAAAEREKQ
 1357- 1370 (23.44/19.69)	EREREQQQQQDQQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07981 with Med13 domain of Kingdom Metazoa
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