<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07980

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSAELRIVKLFEEVLEDKNIVPSFDEEEQRKKTEEGYKKIGTLFGAMTPEVKEASIRSYLGYVATVNHQNRVHNYLQVMNRMVALNIIPAKLLCDQLMCSDKLVYRNPCFWIEAFRLIRKVIGGVDYKGVREIMKCCKEKALSFPANVSVNILPQLLELIELIEHIFNRNACLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSSMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDEELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMEYSEKEGTQAQNTAGTTMNEHDADQSHTQWVWLHLSSQLIYFVLFQFATFQNIVNALHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKESLPVPDNSNPNCTHQMAPTCIWIHLMKRAQTENYNINRPIPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMGGGVQPLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYLSEPKPPGNIVSAESEELNRALILTLARSMHITGTGNDPQSSAWCKDLLQNIMLSTPHAWPQHTLYCFPPVLNEFFMQHNIPKESKQLLKKTVDEEYRNWASMTNENDIIAHFGMTVNPPLFLCLVFKMIIETDVISPVAYKILERIGARALSTHLRKMCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIVTIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTSEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPTLPVYFGNVCLRFLPVLDIIVHRFLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWALTEAYQAYIMTKETDNVNWVPELSYYINLVRRMQDTMDGKNIFSGTDWRFNEFPNPPAHALYVTCVELLGLPVGPNVVANSIIDVLVKGYTVVPNAVIHNWTNTIGLIMAALPEAYWSVIYERMQGALNSKAMKEWTYRQSPFEMFNFKIVKESMLDRSYVTVLAIVHSIFHHFGIGQLATVTESMKEKLKPLVHTEYQLIYVCHVVGPFLHRLSIERVRAVADITLMLYELLEQVDKAQPTQPIRYMDPICDLLYHIKYMFVGDTMKTELEAIIRRLRPALQMRLRFITRLNVEEIGVEQKASTAQGVANSATGVTATGGAAPGTTGTGQGVVAPGQVATGTATGSQQQQTQVSGVANPNVALQQQLQQQMGQGIQSHH
Length1433
PositionTail
OrganismAnopheles culicifacies
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles> culicifacies species complex.
Aromaticity0.09
Grand average of hydropathy-0.111
Instability index43.45
Isoelectric point7.79
Molecular weight163828.94
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07980
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1126.68|     308|     326|     664|     986|       1
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  361-  665 (316.90/197.45)	.............................NIVNALHEKLA...VRNLRRGRdHlmwvflqyISGS..IQKhsilnflPILKLY..DILYPEKES....LPvpdNSNPNCTHQMAPTCIWIHLMKraqtenYN......INRPIP..IALR..LHF.EY............LQHLAMpSNNPT...LFmgseyrfalL.CN.AYS..TQTDYFSrPMQALID................TILGN...SKNPQ..........ANMGGGVQplptAPLSMRVLDSLTIHS..........KMS...LIHS...IVMHMIKQAQnkssipNGNNMAPALVETYSRLLVYTEIESlGIKGFLGQLLPQVFKSQAWgilytllemfsyrmHHIHSHYRVQLLTHLHSLAS......VPH.TNQMQ..L.......................HSCVE.ST
  666-  988 (502.55/358.57)	ALRLIIG.LGSvevqaqLSRYLSEPKPpgNIVSAESEELNralILTLARSM.H........ITGT..GND.......PQSSAWCKDLLQNIMLS....TP...HAWPQHTLYCFPPVLNEFFMQ......HN......IPKESK..QLLKKTVDE.EYRNWASMTneNDIIAHFGM.TVNPP...LF.........L.CL.VFKMIIETDVIS.PVAYKIL................ERIGArALSTHLRKMCDYLLFEVANSGGGAH....VNKCVDTINDMIWKY..........NIV...TIDR...LVLCLILRTL......DGNEAQVSFYIIQLLLLKTSEFRN.RVQEFITINSPEHWKQNNW..............HERHLAFHQKFPEKFAPDES......VSHPTLPVY..FGNV.......CLRFL.PVLDIIVHRFLEvPT
  993- 1310 (307.23/192.93)	TLDVILDhLGS......LYKFHDRPIT..................YLYNTL.H........YYERklRDR.......PQ...LKKRLVGTVVGSlkdvRP...ENWALTEAY......QAYIMT......KEtdnvnwVPELSYyiNLVRRMQDTmDGKNIFSGT..DWRFNEFP....NPPahaLY.........VtCVeLLGLPVGPNVVA.NSIIDVLvkgytvvpnavihnwtNTIG..LIMAALPEAYWSVIYERMQ...GAL....NSKAMK.....EWTYrqspfemfnfKIVkesMLDRsyvTVLAIVHSIF......H......HFGIGQLATV.TESMKE.KLKPLV......H....................TEYQLIYVCHVVGPFLHRLSiervraVADITLMLYelLEQVdkaqptqPIRYMdPICDLLYH.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.15|      10|      44|     297|     306|       2
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  297-  306 (18.15/ 7.96)	LEEQLVWLVL
  344-  353 (15.99/ 6.26)	LSSQLIYFVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.08|      50|     145|      87|     144|       3
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   87-  144 (71.77/71.85)	IIPAKLLCDQLMCS..DKLVYRNPCFWIEAfRLIRKVIGGvDYKgvREiMKCckeKALSF
  235-  286 (89.30/56.60)	IIPWKLDPDTLKLSlrGNLPYDEELLQPQA.RLLRFVLQQ.PYS..RD.MVC...SMLNF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07980 with Med23 domain of Kingdom Metazoa
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