<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07973

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLIPKLHEHYHQGPLQEKPSSGSTGSSSGMSSTNSGLGLGSGTGGTNPSTIPPPLSSPAGSMHSPASGNPVGGSMHGQQQQQQQQPISPQEEQRIAQRQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLHDFVQSERFCRRLAYAVSKKLAQLINQMAESHNINLNSPDPDGNGKQTSNEMSDSKADKQHDKPPKEGTNGSVSQSADTIPPKVNPYEMIFAEYLHCSHHRDVVLQLSSILQVITLECPTALVWCGVGETRSSSVFSGSPLDHLPVAPSALPMPTRYENSNEDIRRQLFEAEESIKVRSRHAESRWCIDKWQTAAGNASLKILVTLDALDGHCFDRMDSNNSLDSLYSKIFPPFQVQPIKPSESSSGGSGNGSGNVAGGTNTADGKDAATKQFEYNVDQDASIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVLTALENDSYNNTLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLEEGGSSQNKSQFTNHVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDSHGMCNAGLGTGPISNKPATSSSPNNGGGMEDDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTGLGKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFESTSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAVGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVELQLIGKSSMALVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKSRPQQEPFHNAYPKIKQALYTPLQPTPSAHTYNPQFMIDIITNPRRGGKIESAWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGTGKRSGLNTPVHPGSTPKSMAGSGDLSHILGTSDLSILGNPDESMLDVSMIELGELSPTASARLYSSRQQNSHLNQENATSLSDFAQHVLRQICSQEWVLERCLQHAEELCQHGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSPDLSNWLDMVARAAIDVFRVNEFTMSNPDAIKQEKVKPSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKHKDGNGGNNSSNNNSHNHGANSNSSVSSNGSTFGSKQSSQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYSQLSQFLQNRDQSLETIGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVLTCDSAGSSTDAKGNKIAIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTGSKKSKTTRKRKPKATAAAQVQQSQPQQPIMPAIVPQTAAGPQQLQQMQQQQQQQQQQQMVQQQSLQQQQHLQQQQQQQLHLQQQQAQQQQHLQQQQQQQLQQLQQQQQQQLQQQQQQNQMMMQQQQQSNIPQQQQSALQQQQQLGAQQPQQQQVGMTPQQTLQQMQNNNMGSMQMGGPMNSMNQQHMQQQYGQANPAQLVAQGNIGGMQTGMGGLGAGMSGGMLNQQQQQQQQAAQQQQPQQAQQVQQAQQAQQQQQQQQQPQGNANMGFVGNVNPMAQLAQQQGGNQQWGGYGSMQQQHQQQQQQQQQQQQQQQPQAQSQQQQQTPQQAQQSQQQGPQQGPQQASQQGPQTQQQLQQQQQQQQMFYSGMGQATMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPTGFMQPQQQQQQPQRNPQQQFLRGPLRAGMPGNPIVGAQTGMGPMNPAMAGGNASIGATSGGAVMGAQSMTAGGMMGAGQGAQGQQTTGGIMNQNAPAMMGTSGGSIMGQSGGSMIQTNMMNPQQNPALVGQGMGSSGGIGGAGGMAGNTGMGGNAGGMGASGGGMVTSGGMVSAGMGNAGMGNAAPMGGGQGGMGGTSGMPNTGGMGNPSMGNPGMGMQNMQQSGNMQGGMFQGQNVPYQNVNQNYPNYGNQSMGQQGGQGGGMMGNFNQMAQQQRTTQAEFLAQQRAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVAGNMAQNQQQFQQQRMRLIMQQHSGMGQGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
Length2773
PositionKinase
OrganismAnopheles culicifacies
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles> culicifacies species complex.
Aromaticity0.05
Grand average of hydropathy-0.619
Instability index53.52
Isoelectric point6.77
Molecular weight303687.93
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07973
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     323.96|      18|      19|    2022|    2039|       1
---------------------------------------------------------------------------
 1996- 2018 (29.10/ 7.05)	PQtaagpQQ.LQQMQQQQQQQQQQ
 2022- 2039 (36.67/11.37)	QQ.....QS.LQQQQHLQQQQQQQ
 2043- 2060 (37.47/11.83)	QQ.....QQ.AQQQQHLQQQQQQQ
 2073- 2090 (31.34/ 8.33)	QQ.....QQ.QQNQMMMQQQQQSN
 2094- 2112 (28.79/ 6.87)	QQ.....QSaLQQQQQLGAQQPQQ
 2192- 2208 (29.62/ 7.35)	QQ.....QA.AQQQQP.QQAQQVQ
 2209- 2226 (33.51/ 9.57)	QA.....QQ.AQQQQQQQQQPQGN
 2252- 2269 (30.83/ 8.04)	GG.....YG.SMQQQHQQQQQQQQ
 2288- 2305 (30.84/ 8.05)	PQ.....QA.QQSQQQGPQQGPQQ
 2307- 2324 (35.78/10.86)	SQ.....QG.PQTQQQLQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     130.00|      22|      23|    2511|    2532|       2
---------------------------------------------------------------------------
 2168- 2183 (29.16/ 6.55)	GMQ......TGMG....GLGAGMSG....G
 2512- 2537 (44.35/13.86)	GMA....GNTGMGGNAGGMGASGGGmvtsG
 2538- 2560 (28.31/ 6.15)	GMVsagmGNAGM.GNAAPM...GGG...qG
 2615- 2631 (28.18/ 6.08)	PNY....GNQSMGQQGG....QGGG.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     477.51|      80|     100|    2569|    2668|       3
---------------------------------------------------------------------------
 2271- 2366 (42.54/ 8.54)	........QQQQQQPQAQ..SQQ....................qqqtpqqaqqsqqqgpqqgpqqasqqgpqtqqqlqqqqqqqqmfysGM.GQ...AT.MnrfD.RPQLN.TNSKQALSNM....LRSK.L..P......INAGH
 2367- 2431 (87.77/25.59)	PTG.FMQPQQQQQQPQRN..PQQ.........QFLRG..PLRA..............................................GMpGN...PI.V...GaQTGMGpMNPAMAGGNASIGATSGGAV..............
 2432- 2500 (65.26/17.10)	.MGA......QSMTAGG........MMGAGQGA...QgqQTTG..............................................GI.MNqnaPAmM...G.TSGGS.I..MGQSG...GSMIQT.NMmnPQQNpalVGQG.
 2563- 2614 (90.25/26.07)	..............................GGTSG.M..PNTG..............................................GM.GN...PS.M...G.NPGMG.MQNMQQSGNMQGGMFQGQNV..PYQN...VNQNY
 2632- 2695 (84.37/29.80)	MMGNFNQMAQQQRTTQAEflAQQRaAMAAGRGQYGQH.aPNV...............................................TM.GN......M...GvNQGAV.PPYPRQ......G...GKPG..............
 2696- 2766 (107.32/32.96)	VAGN...MAQNQQQFQ.....QQR..M...RLIMQQHsgMGQG..............................................GN.AQ...GM.M...Q.NQGQG.M.STQQTPNLVAQL.QRQ.M..PNQN.nmMGQQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.78|      13|      24|    1697|    1712|       5
---------------------------------------------------------------------------
 1697- 1712 (15.20/18.22)	LQNRdQSLetIGGIED
 1723- 1735 (24.57/13.67)	LQLR.YSL..VGGLFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.49|      27|      27|    1744|    1770|       7
---------------------------------------------------------------------------
 1744- 1770 (44.98/28.60)	TTDW..AILFAQLISQGVIDLSNNSELFT
 1772- 1800 (39.51/24.18)	TLDMlaTLIHSTLVSDSQTERDENKKLYT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.46|      15|      19|    1379|    1395|       8
---------------------------------------------------------------------------
 1378- 1392 (26.98/21.00)	PGSTPKSMAGSGDLS
 1395- 1409 (25.48/10.89)	LGTSDLSILGNPDES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.23|      12|      20|    1575|    1586|      12
---------------------------------------------------------------------------
 1575- 1586 (20.59/14.13)	PDAIKQEKVKPS
 1598- 1609 (19.63/13.04)	PSAVQGRILKVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.35|      17|      19|    1848|    1864|      13
---------------------------------------------------------------------------
 1848- 1864 (28.67/20.64)	GNK..IAI.DSIE.KKNGLRL
 1865- 1885 (16.68/ 8.43)	GDKqrVSVwDLLEgHKNPAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.60|       9|      28|    1919|    1928|      14
---------------------------------------------------------------------------
 1919- 1928 (15.05/11.56)	PSSyYYEPLP
 1950- 1958 (18.55/ 8.46)	PSS.DQSPAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07973 with Med12 domain of Kingdom Metazoa
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