<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07969

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSSSSSGGRFNTKRISCHAASCFDSCFDLPTPLAFLPIADTMWVKSFIFGPWESDIFSLIMAEDISWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFIKARNKDEYLGFVARLILHVREMNTKHKNQQNAAAAAAQQAQQDGGGNSNQQGGGGGGGGGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGAGNASNLLHSLRPQMQMGGMGGPMQGNRVGMGPGPSNQMGGMMGPNQMQGPGAGMVGGMPGQMGVGLGPGGMSGGKIVGMGGQQQQMAQLNAMQVNQMQQAQQQQGGMAQPQQQQQQGGLVQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQSAMAGQQMGTVGGTMNAGNQMGPMVGANAGMNSQAMGMAPNQVMRQQQQGMGQMLGTNAGGAAGQQGNFVGMGGNTMVRKPPDMMPGGNVYPGSGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMSGVAQRSNIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYRALTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILSNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAVSSSLQGASGNHTLQRTFRPCLEALFGPDIKNLPPPAKQPRLAQDDSSVANGGTASGVTSGGATTTTSTTTAVTSTASGGNTTGSAATTNTTTSTAPQEIPHILQVEIARLDQKFKVSLDQCAISGTRTIKLICWLDDKNLPCVPPVAVTIPEDYPLTAPSCSLIEQEYNATPFLILVQKSLMARICKLPGLFTLSHLLDTWEMSVRQACSPNPTIVAPTGTSVLLGM
Length849
PositionTail
OrganismAnopheles culicifacies
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles> culicifacies species complex.
Aromaticity0.03
Grand average of hydropathy-0.354
Instability index49.51
Isoelectric point8.95
Molecular weight88386.76
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07969
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     154.35|      32|      32|     187|     218|       1
---------------------------------------------------------------------------
  132-  162 (36.75/ 7.40)	.NQQ...NAAAAA.....AQQA....Q..QDGGGNSNQQG..GGGGGG
  163-  203 (49.93/12.73)	GGMPdpiNALQNLasqgtRPQM.....mgQMGVGPGGPMG..GQMGGA
  204-  229 (33.74/ 6.18)	GNAS...NLLHSL.....RPQM....QmgGM....GGPMQ..GN....
  492-  531 (33.92/ 6.25)	IPSP...ALIPSP.....NPHMsgvaQrsNIGQSPGGSLNtpGQPGGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     251.77|      32|      33|     318|     349|       2
---------------------------------------------------------------------------
  275-  298 (33.89/ 7.31)	..SGGKIVGMGG.QQQQM...A........QLNAMQVN
  300-  317 (30.98/ 6.04)	M.Q....QAQ.....QQQG..GMA...QPQQ.....QQ
  318-  349 (71.71/23.80)	Q.QGGLVQGQGG.PVQQMG.VGPG...GPNQMNPMVMG
  350-  384 (35.45/ 7.99)	QiQAQL.QNQSAmAGQQMGtVG.GtmnAGNQMGPMV.G
  392-  418 (45.20/12.24)	Q.AMGMAPNQVM.RQQQQG.MG........QMLGTNAG
  423-  444 (34.54/ 7.59)	Q.QGNFV.GMGG...NTMV.RKP.....PDMM.P....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.92|      16|      16|     682|     697|       5
---------------------------------------------------------------------------
  682-  697 (27.28/14.23)	GGATT.TTSTTTAVTST
  700-  716 (23.64/11.42)	GGNTTgSAATTNTTTST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.07|      17|      26|     602|     621|       7
---------------------------------------------------------------------------
  602-  621 (24.37/24.51)	LTSqlgSIRETPTNN.......PLVEA
  622-  645 (23.70/13.52)	VSS...SLQGASGNHtlqrtfrPCLEA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07969 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALTSQLGSIRETPTNNPLVEAVSSSLQGASGNHT
2) AQLNAMQVNQMQQAQQQQGGMAQPQQQQQQGGLVQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQSAMAGQQMGTVGGTMNAGNQMGPMVGANAGMNSQAMGMAPNQVMRQQQQGMGQMLGTNAGGAAGQQGNFVGMGGNTMVRKPPDMMPGGNVYPGSGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMSGVAQRSNIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKY
3) NLPPPAKQPRLAQDDSSVANGGTASGVTSGGATTTTSTTTAVTSTASGGNTTGSAATTNTTTSTAPQE
4) NTKHKNQQNAAAAAAQQAQQDGGGNSNQQGGGGGGGGGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGAGNASNLLHSLRPQMQMGGMGGPMQGNRVGMGPGPSNQMGGMMGPNQMQGPGAGMVGGMPGQMGVGLGPGGMSGGKIVGMGGQQQQ
601
290
653
127
634
548
720
288










Molecular Recognition Features






MoRF SequenceStartStop




NANANA