<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07962

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPQPLEQGGAVTSFIPTGQEMTQRQNLIPLGRLIDFIIQRTYHELTVLAELLPRKTDMDRKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMGFLDKQSMLFIDTADMLSRVARETLVHARLPNFHIPAAVEILTTGSYSRLPSVIRDRIVPPDPITPAEKRQTLQRLNQVIQHRLVTGSLLPQLRKFRIENGRVTFKVDHEFEVSLTVMGDAPTVPWRLLDIDFLVEDKETGDGKALVHPLQVNYIHQLIQGRIVDCTDALAEVYTCLHYFCQSLQLEVLYTQTLRLIRDRLDDHIHVDEYVVGSRLTVSYWRELTNKDPKSELGYRLTIQTDPNDAAKQLAILHVPSIGNKEADIADRAVRSDLLSMERLLVHTVYVRSLARLNDVKTELQLFLKDVEYHIQGTPAMLTVPVLNPCLRAEHIYITVDTHTGMLRCHVPKHLDCPIMPEMQHALNNDWSKLQHLISELRYWITQRRCEKTLQHLPAATQDRLPLIYPQNHPIARMGPHKVFIQLYRHANVILIVELKEKKTCPNEMTYTFYLVLVKPSSVEEGQSQDTAAAGQSNTTSGTGGHASGNEQTTAAMPKMYLRVLSMIEFDTFVATHGPGTYIDDPSPTCSSSKRKLSPLDSAMSSMGPPLKQQKTIYPAYFIPELAHVVAMCDEKLPFVTLAKEFTMRKIPHGGLQVEANATSLVLKLLTLPQPKPPQVPPSAQQQQQQQQQQQQQSGQSASDPKAAAAASANEPKTVHVPPIDKQVWNALLKRLLSVSVRAQVNKSNQTRLWTMELVFYGSPLPSLHHKEQGMRRAVYLQYEMQPVESVSKVVDQLLSDWSKIVYLYTLVHEFREQFNNEKYNLQSMVTIKSYSYTNLLLAYGPNKDVSVNICWDTEAKEFRLVFTGGNSAINAHSMMRDQLQAHLNHNYSLAQIVHMLHETYQPLSSIAKLPIIPHMAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRFRGGGLCTIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVFRRRSQSEDDNPPSPVTMEDPSGHVGAGGGTGGGNNGGAGGGGSTGGGSNTFLSGGTGMRGPQSPRDPGLRFAAPLTPPTSSNPHTPASPHPIGGGGGAGGAGGGGGGGAGGTGGQGGQQQGHMNNFNMTSPPASHMPHPSPSGGLMPSSPLNAQPSPMAAHSPGPSSLPYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYTSRVLPARSWAGAIPTTLTYEALDTLCRATSHPQKEVPGPELSPLERFLGSVFMRRQLQRIIHQEESLMAITSNEPGVVVFKADCLQYQVFLNPNHMQSLHLKVDQLSMGPMMDGKPPYQWAAQDLQILEQFFDQRVAAPPYRPAVMTSFTRMLNLPAKVLKDFIQIMRLDLMPELVQGNKWNVQLVLRVPPSATPIVPVGTATILFHRQKILFFIQITRIPYMPNMEWKDAVTMLLPMVYDMNMNHTTLAERREPMPPQLNSAVSAHLRRFSECSVLLPDECSLFPAVHDLLLTLTLPNEPPAPGQMQMQMGGVMQPGGGPGGPGGPGGPMGGQIGGPSTQVVPQVGSSPSPMMHSPMQQMGGGGQQPGAYGGMVGGPGGGPQSGGPGGGGPGGGV
Length1651
PositionTail
OrganismAnopheles culicifacies
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles> culicifacies species complex.
Aromaticity0.07
Grand average of hydropathy-0.291
Instability index53.61
Isoelectric point8.54
Molecular weight181267.90
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07962
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     409.94|      61|      65|    1048|    1111|       1
---------------------------------------------------------------------------
 1048- 1105 (95.38/38.13)	........P.PSPVTMEDP....SGH.VGAGGGTGGG.NNGGAGG....GGSTGGGS.......NTFLSGGTGMrgpQSPRDPG
 1106- 1169 (70.81/22.73)	LRFAAPltP.P...TSSNPhtpaSPHpIGGGGGAGGA.GGGGGGG....AGGTGGQGgqqqghmNNF.....NM...TSP..P.
 1170- 1232 (77.94/25.74)	...ASH.mPhPSPSGGLMP....SSP.LNAQPSPMAA.HSPGPSSlpymQSHTDGSP.......FAALSPAAS....NWPGSPG
 1552- 1608 (107.54/38.23)	LPNEPP..A.PGQMQMQM.....GGV.MQPGGGPGGP.GGPGGPM....GGQIGG.P.......STQVVPQVG....SSP.SPM
 1609- 1650 (58.26/16.93)	MH..SP.mQ.QMGGGGQQP....GAY.GGMVGGPGGGpQSGGPGG....GGPGGG.............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.53|      13|      40|     709|     721|       2
---------------------------------------------------------------------------
  709-  721 (26.44/12.48)	QPKPPQVPPSAQQ
  750-  762 (25.09/11.44)	EPKTVHVPPIDKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.02|      24|      73|     392|     432|       3
---------------------------------------------------------------------------
  392-  415 (41.89/54.07)	LNDVKTELQLFLKDVEYHI.........QGTPA
  462-  494 (38.13/14.15)	LNNDWSKLQHLISELRYWItqrrcektlQHLPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     197.58|      67|      75|     112|     186|       4
---------------------------------------------------------------------------
  116-  186 (98.85/85.62)	LSRVARETLVHARLpNFHIPAAVEI.LTT.GSYSRLPSVIRD.RIVPPDPITPAEKR..QTLQrLNQViqHRLVTG
  189-  260 (98.74/60.09)	LPQLRKFRIENGRV.TFKVDHEFEVsLTVmGDAPTVPWRLLDiDFLVEDKETGDGKAlvHPLQ.VNYI..HQLIQG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07962 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FRRRSQSEDDNPPSPVTMEDPSGHVGAGGGTGGGNNGGAGGGGSTGGGSNTFLSGGTGMRGPQSPRDPGLRFAAPLTPPTSSNPHTPASPHPIGGGGGAGGAGGGGGGGAGGTGGQGGQQQGHMNNFNMTSPPASHMPHPSPSGGLMPSSPLNAQPSPMAAHSPGPSSLPYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYTS
2) LTLPNEPPAPGQMQMQMGGVMQPGGGPGGPGGPGGPMGGQIGGPSTQVVPQVGSSPSPMMHSPMQQMGGGGQQPGAYGGMVGGPGGGPQSGGPGGGGPGGGV
3) TLPQPKPPQVPPSAQQQQQQQQQQQQQSGQSASDPKAAAAASANEPK
1037
1550
706
1256
1651
752










Molecular Recognition Features






MoRF SequenceStartStop




NANANA