<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07957

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSSGTTAVSGGSLPALLMANGSSVGGGGGVGTGKGIGKPDIKPPGTGTSAGGAVGSTGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFPEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPADGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALENDLHTLYTMSMQHFPDVHSQLLKAPLGVVQKRRGGHPMRLTYFVAPYELLDLGTRTMNVLSPELIAKERIGCSVAVVLEASSANKLQIQPLLVVNGSASTAPTGQPVYTPIEKHNSTSLPATFVLRLSKPMPINGAVMRAIKATVGGSGANEQQSGEGTGTGGASGLPASLLGLIAHHASGGTVTDLAKGLLVSLPDQYHCYYLTDNPLLRGVMVSSIPFTEPQHVPKILTYLRQQAIFNQLLSSCIRSNTSAAGGGRPSALQLLLDGGTHTIENGSAGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANISVRIYCSEGETSDEHTVERLSAVLQRCMSIPVTLRALMKHWEEEHEQKFKPNLLGSSTVSSSGSGGGGGPGGGMGGTGTGLNSGGDGTGTGGGVAGSGEDGSMNGFNLSSLGGPPSTVDGAGGTGGGGGGGGGGSAATNGTSAQQTASQRGLMNGEGNGLVASGNLGLDFCDMLTERNGNGLAGNGRVAGALGTREPPEPLAGGVAKKRRMEDFCKSPKSDSNLSVVGGGTDGSGVEKSNDTGAISNTVTSQDVAAAASGGTAGNGEQRMQAGGATEEDTGGLALFGETVPVSGADAKGSSLGGTTITNTNASAKNEPPSVLPADDDAAVKMPLQSSSSSSLSSLSSSGFSLTGAPSGEAGSDRPCPGTLLLESLESSGLEPDPTKRSGGQSTKRRRSSSSSSSSSSSSSSSSSSSSTTSGASEDVEESIDLVEAEMNSFFAEVNNTQPTATGASKGMFGSASGKPALGAASPIASKLVSPSSGAGMEKPITSIGSSGLEIIPIPTGSAGNITATAFPSTTVTSTPITVPQNIANSSASSTTSLTTTSTASKKSSSSSSSSSSSSHRKSSETSSERSSSSKSDKKKKRKVDESGHLAMGPPNKLPFKSGESSPHRSGIGSSSATGNKSSPKHSSPVHHSSPKHTGSSSGLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGTKSSETSGGGGVGGGGSGIGISTTSGSSKERDKERSEKKTLQFSTTNATTGSSLSANSTSSSGSSSGGRSKNSGLKLKQLDLTAGSSMTISMGDSGSSSPVAPMIDLTGTMQGSSLGGALGLAGSGMTTASSMLQALQAAKNRKPPSSAGGTGLGGSLSAVIDKLKSAQSADDEAVLVLPEMTITQQTTSTSLTGGVGIGAGVNIGGLGSIGGSGALKDPSKAGSGLLSGTGSGSLTNCVSSTTGIGAALTQSSSMTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSSKSSSNSSGGSKSGSGSNKSGLKSGVSSGPISSKQQQQNHTTSFSGAFPSSTKSPHYSSSSSSSSKTPFQKSNSFGSLGGGSGGGTGMKTSKVSSPKSTSNPASSSSSSYSSKEKGGPASGRSKSSSASSLTGAALLSGGSSGGGSSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNNNSTAAGTGHSESNEATKSLKDPAVRKQKPQLPITSSPQSVGSSPLRTFSTSPSGDASARLLSDLLGAAAKGGSKMSSSGTGSSAASGDGGGAGNALHPLLPNIVQKMFGSDGSLQSKSNSSDGSMFPSAGRASPGMLSGSASRDGFRSGTGSAPGTPTTSGSMVLPPFPSPVSGGASNDGDAGSGTGTLMRPPSRPSSTISNHSHSSQDGIGGGVNSSGDVGPSAVTSMASMMMMSAMSAAGGQSPASGSLSLDSASTQQLIAALAAKSGATGGGGGVLPPPNSLLNNHLHHHGNHLNNHVAGGTAAALNNLPSPASVSVHIVKSPAPSPLPFTSPHSNASSTHGGPGTGGLDDDLMDEALIGIGSK
Length2106
PositionMiddle
OrganismAnopheles culicifacies
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles> culicifacies species complex.
Aromaticity0.03
Grand average of hydropathy-0.322
Instability index51.60
Isoelectric point9.05
Molecular weight209203.17
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07957
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     255.30|      59|      61|    1548|    1606|       1
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  630-  685 (56.20/ 9.01)	PGGGM.GG..TGTGLNSGGDGTGTGGGVAGSG....EDGSMNGFNLSSLGGPPST......vdGAGG.TG
 1265- 1323 (55.83/ 8.89)	GGVGG.GG....SGI..GISTTSGSSKERDKErsekKTLQFSTTNATTGSSLSAN.STSSS..GSSS.GG
 1559- 1617 (93.00/21.52)	SKSGS.GS..NKSGLKSGVSSGPISSKQQQQN....HTTSFSGAFPSSTKSPHYS.SSSSS..SSKT.PF
 1618- 1681 (50.27/ 7.00)	QKSNSfGSlgGGSGGGTGMKTSKVSSPKSTSN....PASSSSSSYSSKEKGGPASgRSKSS..SASSlTG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     496.31|      60|      60|     931|     990|       2
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  776-  854 (43.06/ 6.67)	KSPKSD.......S..NLSVVGGGTD..............G..S.G.........VEKS.................N.DT......GAISNTVTSQdvaaaaSG..GTAGNGEQ....RM....QaggateedtgglalfgetvpvSG
  855-  899 (47.74/ 8.58)	ADAKGS.......S..LGGTTITNTN..............A..S.AKNE......PPSV..........L.PADD...............................DAAVKMPL....QS....S.....................SS
  900-  962 (71.15/18.13)	SSLSSL.......S..SSGFSLTGAP..............S..GeAGSD....rpCPGT..........L.LLES.L.ES......SGLEPDPTKR......SG..GQSTKRRR....SS....S.....................SS
  963- 1025 (59.65/13.43)	SSSSSS.......S..SSSSSSSSTT..............S..G.ASED......VEES..........IdLVEAeM.NS......FFAEVNNTQP......TA.tGASKGMFG....SA....S.....................GK
 1119- 1192 (53.35/10.87)	SSSSSS.......ShrKSSETSSERS..............S..S.SKSDkkkkrkVDESghlamgppnkL.PFKS.G.ES......S.....P.HR......SGigSSSATGNK....SS....P.....................KH
 1193- 1243 (64.82/15.54)	SSPVHH.......S..SPKHTGSS................S..G.........................LgFHSP.K.HG......SSVSPKHPLH......SG..GSSTGGGK....PS....M.....................SA
 1475- 1546 (55.71/11.83)	PSKAGS.......G..LLSGTG..................S..G.SLTN......CVSS...ttgigaaL.TQSS.S.MT......SAPSLTAALT......SG..KASEYMVK....PS....S............dgikltiqnKK
 1820- 1895 (46.72/ 8.16)	GSSAAS.......G..DGGGAG...NalhpllpnivqkmfG..S............DGS..........L.QSKS.N.SSdgsmfpSAGRASPGML......SG..SASRDGFRsgtgSA....P.....................GT
 1896- 1964 (54.12/11.18)	PTTSGSmvlppfpS..PVSG.GASND..............GdaG.SGT.........GT..........L.MRPP.SrPS......STIS.NHSHS......SQ..DGIGGGVN....SSgdvgP.....................SA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     456.58|     115|     634|    1339|    1463|       3
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 1351- 1469 (184.69/52.21)	GSSSPVAP..MIDLTGTMQGSSLGGALGLAGSgMTTASSMLQALQAAKNRKPPSSAGGTG.LGGSLS......................AVIDKLKSAQS.....ADDEAVLVL.PEMTIT...Q.......QTTSTSLTGGVGIGAGVN.......IGGLgsiGGS
 1693- 1812 (148.20/41.05)	GSSALVNPisIMKMLGYPTG.SMGNMEGFAKS.LDT.KFQIPKLSARSNNN..STAAGTG.HSESNE......................A.......TKS.....LKDPAVRKQkPQLPITsspQsvgssplRTFSTSPSGDASARLLSD.......LLGAaakGGS
 1969- 2104 (123.69/31.44)	......AS..MMMMSAM...SAAGGQSPASGS.LSLDSASTQQLIAALAAKSGATGGGGGvLPPPNSllnnhlhhhgnhlnnhvaggtaAALNNLPSPASvsvhiVKSPA..PS.P.LPFT..sP.......HSNASSTHGGPGTG.GLDddlmdeaLIGI...G..
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.05|      52|     656|      27|      79|       4
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   27-   79 (89.43/36.83)	GGGGvGTGKGIGKPDIKPPGTGTSAGGAVGSTGKVLLGGDKHETWQMELLMER
  686-  737 (91.61/35.05)	GGGG.GGGGGSAATNGTSAQQTASQRGLMNGEGNGLVASGNLGLDFCDMLTER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.68|      34|     615|     456|     501|       5
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  456-  501 (52.37/53.08)	VSSIPFTEPQHvpkiltylrqqaIFNQLLSSCIRSNTSAAGGGRPS
 1082- 1115 (55.32/32.13)	VTSTPITVPQN............IANSSASSTTSLTTTSTASKKSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.33|      84|     218|     290|     380|       8
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  290-  380 (126.51/89.05)	LLDLGTRTM.NVLSPELIAKE..RIGC.SVAVVL....EASSAN.KLQIQPllVVNGSAST.APTGQPVytpiEKHNSTSLPATFVLRLSKPMPINgAVMR
  506-  599 (112.82/62.62)	LLDGGTHTIeNGSAGGLLVFEvsALSCqNITVSLihpyEESLATvEFDLQN..IANISVRIyCSEGETS....DEHTVERLSAVLQRCMSIPVTLR.ALMK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07957 with Med1 domain of Kingdom Metazoa
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