<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07949

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPQPLEQGGAVTSFIPTGQEMAQRQNLIPLGRLIDFIIQRTYHELTVLAELLPRKTDMDRKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMGFLDKQSMLFIDTADMLSRVARETLVHARLPNFHIPAAVEILTTGSYSRLPSVIRDRIVPPDPITPAEKRQTLQRLNQVIQHRLVTGSLLPQLRKFRIENGRVTFKVDHEFEVSLTVMGDAPTVPWRLLDIDFLVEDKETGDGKALVHPLQVNYIHQLIQGRIVDCTDALAEVYTCLHYFCQSLQLEVLYTQTLRLIRDRLDDHIHVDEYVVGSRLTVSYWRELTNKDPKSELGYRLTIQTDPNDAAKQLAILHVPSIGNKEADIADRAVRSDLLSMERLLVHTVYVRSLARLNDVKTELQLFLKDVEYNIQGTPAMLTVPVLNPCLRAEHIYITVDTHTGMLRCHVPKHLDCPIMPEMQHALNNDWSKLQHLISELRYWITQRRCEKTLQHLPAATQDRLPLIYSHTHPIARMGPHKVFIQLYRHANVILIVELKEKKTCPNEMTYTFYLVLVKPSSVEEGQSPDVLSGQPPQPSAAGGPAPGSDAANAAMPKMYLRVLSMIEFDTFVATHGPGTYIDDPSPTSTSGTSVKRKVSPLDNALSAIGPPLKQQKTIYPAYFIPELAHVVAMCDEKLPFVTLAKEFSMRKIPHGGLQVEANATSLVLKLLTLPQPKPPQAPPTPQQQQQQQQQQQQPGTSDAKSSGAGASANEPKTVHVPPIDKQVWNALLKRLLSVSVRAQVNKSNQTRLWTMELVFYGSPLPSLHHKEQGMRRAVYLQYEMQPVESVSKVVDQLLSDWSKIVYLYTLVHEFREQYNNEKYNLPSMVAIKSYSYTNLLLAYGPNKDVSVNICWDTEAKEFRLVFTGGNSAINAHSMMRDQLQAHLNHNYGGGLCTIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVFRRRSQSEDDNPPSPVTLEDPSAGAGNNGGGGGGGGGAGGGANTFLSGGTGMRGPQSPRDPGLRFAAPLTPPTSSNPHTPASPHPIGGGGGAGGAGGQGGQGGQGGQQQGHMNNFNMTSPPASHMPHPSPGGGLMPSSPLNAQPSPMAAHSPGPSSLSYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYTSRVLPARSWAGAIPTTLTYEALDTLCRATPHPQKEVPGPELSPLERFLGSVFMRRQLQRIIHQEESLMAITSNEPGVVVFKADCLQYQVFLNPNHMQSLHLKVDQLPMGPMMDGKPPYQWAAQDLQILEQFFDHRVAAPPYRPAVMTSFTRMLNLPAKVLKDFIQIMRLDLMPELVQGNKWNVQFVLRVPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMEWKDAVTMLLPMVYDMNMNHTTLAERREPMPPQLTSAVSAHLRRFSECSVLLPDECSLFPAVHDLLLTLTLPNEPPAPGQMQMQLGGVMQPGGGPGVPGGPGGPMGGQIGGPTPQVVPQVGSSPSPMMHSPMQQMGGGGPQPGAYGGMVGGPGGGPQSGGPVGGGPGGPN
Length1573
PositionTail
OrganismAnopheles coluzzii
KingdomMetazoa
Lineage
Aromaticity0.07
Grand average of hydropathy-0.315
Instability index52.15
Isoelectric point8.37
Molecular weight172644.91
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07949
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     125.86|      16|      16|    1016|    1031|       1
---------------------------------------------------------------------------
 1016- 1031 (24.34/ 6.31)	LSGGTGMRGPQSPRDP
 1064- 1079 (26.38/ 7.52)	GAGGQGGQGGQGGQQQ
 1486- 1501 (24.06/ 6.14)	MQLGGVMQPGGGPGVP
 1503- 1517 (27.16/ 7.98)	GPGG.PMGGQIGGPTP
 1546- 1559 (23.93/ 6.07)	GAYG.GMVGGPGG.GP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     186.32|      35|      53|    1081|    1116|       2
---------------------------------------------------------------------------
 1081- 1116 (71.58/33.51)	HMnNFNMTSPPASHM....................PHPSPGGGLMP.SSPLNAQPSP
 1119- 1138 (27.36/ 6.59)	............AHS....................PGPS.SLSYMQ.S...HTDGSP
 1141- 1166 (47.35/17.36)	AL......SPAASNW....................P.GSPG...MPrPSPRPGQ.SP
 1174- 1220 (40.03/13.49)	H..HYTSRVLPARSWagaipttltyealdtlcratPHPQK...EVP.GPEL....SP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.44|      26|      53|     982|    1007|       3
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  982- 1007 (51.21/23.20)	PPSPVTLEDPSAGAGNNGGGGGGGGG
 1038- 1063 (54.23/25.09)	PLTPPTSSNPHTPASPHPIGGGGGAG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.98|      35|     568|     694|     728|       4
---------------------------------------------------------------------------
  694-  728 (65.00/30.08)	QVEANAT...SLVLKLLTLPQ.PKPPQAPPTPQQQQQQQ
 1265- 1303 (55.98/24.84)	QVFLNPNhmqSLHLKVDQLPMgPMMDGKPPYQWAAQDLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.22|      16|      41|     141|     157|       6
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  142-  157 (27.33/14.27)	TTGSYSRLPSVIRDRI
  168-  183 (26.89/ 9.55)	KRQTLQRLNQVIQHRL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.71|      18|      30|      60|      77|      12
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   60-   77 (30.75/27.51)	DRKIEIYNFSASTRQLFI
   93-  110 (30.96/27.76)	DKSAKIMGFLDKQSMLFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.58|      44|      50|    1309|    1358|      13
---------------------------------------------------------------------------
 1309- 1358 (67.96/66.85)	FDHRVaAPPYRPAVMTSFTRMLNLPAKVLKdFIQIMRLDLMPELvqgnKW
 1362- 1405 (81.63/57.46)	FVLRV.PPSATPIVPVGTTTILSHRQKILF.FIQITRVPYLPNM....EW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.69|      24|      46|    1412|    1437|      14
---------------------------------------------------------------------------
 1412- 1437 (41.85/31.48)	LLPMVYDMNMNHTTLAErrEPMPPQL
 1461- 1484 (44.84/27.02)	LFPAVHDLLLTLTLPNE..PPAPGQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.45|      10|     163|      31|      48|      15
---------------------------------------------------------------------------
   15-   24 (18.99/14.16)	FI..PTGQEMAQ
   37-   48 (13.46/ 6.48)	FIiqRTYHELTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.46|      15|      30|     414|     428|      16
---------------------------------------------------------------------------
  414-  428 (27.13/14.09)	PAMLTVPVLNPCLRA
  447-  461 (30.32/16.66)	PKHLDCPIMPEMQHA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07949 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLTLPQPKPPQAPPTPQQQQQQQQQQQQPGTSDAKSSGAGASANEPKTVH
2) LTLPNEPPAPGQMQMQLGGVMQPGGGPGVPGGPGGPMGGQIGGPTPQVVPQVGSSPSPMMHSPMQQMGGGGPQPGAYGGMVGGPGGGPQSGGPVGGGPGGPN
3) TAVFRRRSQSEDDNPPSPVTLEDPSAGAGNNGGGGGGGGGAGGGANTFLSGGTGMRGPQSPRDPGLRFAAPLTPPTSSNPHTPASPHPIGGGGGAGGAGGQGGQGGQGGQQQGHMNNFNMTSPPASHMPHPSPGGGLMPSSPLNAQPSPMAAHSPGPSSLSYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYTS
706
1472
968
755
1573
1178










Molecular Recognition Features






MoRF SequenceStartStop




NANANA