<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07948

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLIPKLHEHYHQGPLQEKPSSGGAGSSGGLGSGASGLGLGSGAGGTNAVTIPPPLSSPAGSMHSPAGGNPVVGGSMHAQQQQQQQQQQQQPISPQEEQRIAQKQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLYDLVQSERFCRRLAYAVSKKLAQLINQMAESHNINLSSPEPQDASGKQPSIDAPDSKSEKQNDKPSKEGTAGTVAQPADTKPPKVNPYEMIFTEYLQCSHHRDVILQLSSILQVITLECPTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPIPTRYEKSNEDIRRQLFEAEESIKVRSRHAESRWCIDKWQTAAGNASLKILATLDALDGHCFDRMDSNNSLDSLYSKIFPPFQVQPLKPAESASAAGGSGGSGTGNTPSGLAAVDGKDAATKQFEYNVEQDSSIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVLTALENDSYTNNLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLDEAGSPQNKSQFTNLVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDSQGICNAGLGTGPISNKPATSSSPNGGGGVEDDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTGLGKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFESTSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAIGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVELQLIGKSSMALVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKARPQQEPFHNAYPKIKQALYTPLQPTPSAHTYNPQFMLDIITNPRRGGKIESGWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGSGKRSGLNTPVHPGSTPKSMAGSGDLSHILGTSDLSILGNPDESMLDVSMIELGELSPTASARLYSSRQQNSHLNQDNATSLSDFAQHVLRQICSQEWVLERCLQHAEELCQHGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSPDLSNWLDMVARAAIDVFRVNEFILNSPDVKQEKVKLSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKHKDGNGGNNSSSNNSHNHGANSNSSVSSNGSTFGSKQSAQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYSQLSQFLQNRDQSLETIGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVLTCDSAGSSTDAKGNKIAIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTGSKKSKTTTRKRKTKATAAAQVQQSQPQQPIMPAIVPQPAAGPQQMQQMQQQQQQQQQQQQQQQQHQQHQQQQQQQQMQQQQTLQQQQHLQQQQQQLHLQQQQAQQQQQLQQQQQLQQLQQQQQQQLQQQQQQQNQMMMQQQQQPNIPQQQQSALQQQQLGSQQGQQQQQQVTMTPQQTLQQMQNNSMGGMQMGGPMSSMNQQHMQQQYGQANPAQLVGQGNMGGMQTGMGGLGAGMGGGMMNQQQQQQQQQQQQPPQQQQPQQAQQAQQAQQAQQQQPQGNPNMGFVGNVNPMAQLAQQQGGNQQWGGYGSLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQSQVQQQQQTPQQGQQASQQQGPQQGPQQGAQQGPQTQQQLQQQQQQQQMFYSGMGQATMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPASFMQQQQQQQQAQQQQAQRNPQQPFLRGPLRAGMPGNPIVGAQAGMGPMNPAMAGGTAGIGTAGGGAVMGAQGMGAGGMMGAQQTAQGQQGAGGIMNQTTPAMMGTTGGSIMSQSGGSMIQTGMMNPQQNPALVGQGMGGSGGLGGASGMAGNSGMGASAGGMGGTSGGGMVTSGGMVTGGMGSAGIGNTAPMGAGGQGGGMGGNAGMPNAAGMGNPAMGNPGMGMQNMQQSGNMQGGGMFQGQNVPYQNVNQNYPNYGNQGMGQQSGQGGGMMGNFNPMAQQQRNTQAEFLAQQRAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNMPQNQQQQFQQQRMRLIMQQHSGMGQGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
Length2832
PositionKinase
OrganismAnopheles coluzzii
KingdomMetazoa
Lineage
Aromaticity0.05
Grand average of hydropathy-0.636
Instability index56.63
Isoelectric point6.84
Molecular weight309805.62
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07948
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     174.30|      17|      17|    2282|    2298|       1
---------------------------------------------------------------------------
 2018- 2034 (39.26/ 9.17)	QQ.......QQQQQQQQQQQQQQ..H
 2035- 2053 (31.75/ 6.01)	QQ.......HQQQQQQQQMQQQQtlQ
 2273- 2296 (33.61/ 6.79)	QQwggygslQQQQQQQQQQQQQQ..Q
 2297- 2314 (36.01/ 7.80)	QQ......qQQQQQQQQQQQQQQ..Q
 2421- 2437 (33.69/ 6.82)	QQ.......QQQQQQAQQQQAQR..N
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     212.39|      25|      25|    2054|    2078|       2
---------------------------------------------------------------------------
 2060- 2085 (38.10/ 9.37)	QQQQQLHLQQQQAQQQQQL..qQQQQLQ
 2088- 2115 (36.50/ 8.57)	QQQQQQQLQQQQQQQNQMMmqqQQQPNI
 2212- 2234 (33.09/ 6.87)	QQQQQ...QQQQQQQPPQQ..qQPQQAQ
 2324- 2349 (36.86/ 8.76)	QTQSQVQQQQQTPQQGQQA..sQQQGPQ
 2493- 2514 (34.46/ 7.56)	AG.G.MMGAQQTAQGQQGA...G.GIMN
 2623- 2647 (33.38/ 7.01)	AGMPNAAGMGNPAMGNPGM...GMQNMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     123.35|      24|      49|    2468|    2491|       3
---------------------------------------------------------------------------
 2243- 2264 (32.94/ 8.77)	QQQQ.........P..QGNPNM.G..FVGNVNPMAQ
 2363- 2387 (30.04/ 7.16)	QQQL.........QQQQQQQQMfY..SGMGQATMNR
 2468- 2488 (29.77/ 7.01)	...P.........AMAGGTAGI.G..TAGGGAVMGA
 2661- 2693 (30.59/ 7.47)	QNVPyqnvnqnypNY..GNQGM.GqqSGQGGGMMGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     234.92|      51|     179|    2569|    2619|       5
---------------------------------------------------------------------------
 2530- 2589 (53.47/17.96)	SqSGGsMIQTGM..M....NPQ.QNPA......................................................lvgqgmggsgglggasgmaGNSGM..GASAGGMGGTSGGGMV
 2590- 2621 (57.07/19.81)	T.SGG.MVTGGM..G....SAGIGNTAP..........................................MGAG.GQGGGM.....................................GG...
 2648- 2742 (47.21/14.74)	Q.SGN.MQGGGMfqGqnvpYQNVNQNYPnygnqgmgqqsgqgggmmgnfnpmaqqqrntqaeflaqqraaMAAGrGQ...Y...................GQHAP..NVTMGNMGVNQGA..V
 2743- 2799 (77.18/30.15)	P.P...YPRQG...G....KPGVGGNMP..........................................QNQQ.QQFQQQ............rmrlimqQHSGMgqGGNAQGMMQNQGQGMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.26|      25|      39|    2134|    2159|       6
---------------------------------------------------------------------------
 2127- 2154 (34.78/13.44)	QLGSQqgQQQQQQVTMtPQQTLQQM..QNN
 2155- 2181 (43.48/15.05)	SMGGM..QMGGPMSSM.NQQHMQQQygQAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.63|      20|      28|    1740|    1765|       7
---------------------------------------------------------------------------
 1740- 1763 (25.70/34.79)	GLFDaIMKNA...TSTTDwaiLFAQLI
 1766- 1788 (28.93/13.85)	GVID.LSNNSelfTTTLD...MLATLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.88|      13|      28|    1904|    1916|       8
---------------------------------------------------------------------------
 1904- 1916 (23.69/12.68)	ERKPLAYEETHRL
 1933- 1945 (25.19/13.96)	EPLPLPPEEVDPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.56|      15|      15|    1628|    1642|       9
---------------------------------------------------------------------------
 1628- 1642 (26.97/16.65)	SKHKDGNGGNNSSSN
 1644- 1658 (25.59/15.30)	SHNHGANSNSSVSSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.58|      18|      21|    1356|    1376|      10
---------------------------------------------------------------------------
 1357- 1376 (26.57/22.80)	GI.LVVGDATAHKvsSIFGSG
 1380- 1398 (28.02/11.96)	GLnTPVHPGSTPK..SMAGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.44|      15|      19|    2390|    2404|      15
---------------------------------------------------------------------------
 2390- 2404 (26.03/12.74)	RPQLNTNSKQALSNM
 2406- 2420 (27.41/13.83)	RSKLPINAGHPASFM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07948 with Med12 domain of Kingdom Metazoa
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