<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07938

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSASGTAAVSGGSLPALLMANGGGGGSGGPGGGPGGGKGIGKPDIKPPGGGGPSAGGTGTAGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFQEIVAVVLEASSANKLQIQPLLVVNAGSGSAASVLQPVYTPIEKHNSTSLPATFVLRLSKPMPLNSAMMRAIRGIVGGSGAGEQQQAGEGSSGGGGLPGSLLGLIAHHASAGSVTDLAKGLLVSLPDQYHCYFLTDNPSLRGMMVSSIPFTEPQHVPKILTYLRQQAVFNQLLSSCIRTNAPGGGGGRPSALQQLLDGGSVHTIENGTTGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANIAVRIYCSEGETSDEHTVERISAVLQRCMSIPVTLRALMKAWEEEHEQKFKPNVLGSSTVSSGGAGGGPGGGGGGGGGAGGATPGLNNGGDGTGPAGGGLTGSGDDGTMNGFNLSSLGGPGPAVDGSGAGGGGGSAATNGTAAAQQQRGLMNGEGNGLTMSGGGSLGLDFCDMLTERNGSGLGAAAAIGIVGGRAPGGLGAREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVGGGGGGGACDAVGTEKANTGAAGVAGATGATSSSSTTTTTITSQDVGAAASGATGAGNSSEQRLQTGGATEEDTGGLPLFGETVPAAAGTDAKGSSLGGTTTTNAMISAKNEPPSVLPMGGGDGDTATGATMPLQSSSSSSLSSLSSAGFSLAGGPLAGEPAPDRPCPGTLLLESLDFSALEPDAAKRSTGAAQPTKRRRSSSSSSSSSSSSSSSSSSSSSTSAASDELEESVDLVEAEMSSFFAETNNTQPVAAIAKAPFGSPSGKPALGAVSPIASKVVSPSGGAGLEKTPLPTISGSGLEIIPLATSAGTVAASGFPSPSVTSAPIAVPQSNATGSTSSTTATSSSTVKKSSSSSGGGSGSHRKTSDSSERTSSSKSEKKKKRKTDDSAMGPPNKLPYKSSGESSPHRSGGGVGGSSLSTSKSSPKHSSPVHHSSPKHSGSGGPLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDVGGGGGSGGTSGASISTAGSSSKERDKERSEKKALQFGTANTATGSSSLTATSAAGSSSSSSSGGRSKNSSLKLKQLDLAAGSSMSISMAAGIGDAGSSSPVAPMIDLTGPVPGAAAALGGLGLPGPGMTTASSMLQALQAAKNRKTTTAAGGSTGLGGSLSAVIDKLKSAQSADDEAVLILPEMTITQQTTSLAAGTGGIGTGVNIGGFGGLKDSSKSGSGLLPSGGTSSLANCVSSTAGIAGAALTQSSSVTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSNKSSSSNSGSGSKSSNKSGLKSGVSSGPVSSKQQQQQQQQQQQSNHTTSFSGAFPSSTKSPHYTSSTSGSSKAPFQKSNSFGSLGGSGGTGMKASKVSSPKSTSNPASSSSSSAYSSKEKGGSTSGRSKSSSASSLTGTMLTGATGGTGSGTGSSSSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNSGATGTASTGSSESGEAGSKSAKDPAARKQKQQTPVTTAAPSVGSSPVRQFSSTSPSGEASARLLSDLLGAAAKSSNKMAPGTGAASVDGTAGAGGSGGAGLHPLLPNIVQKMFGSDGSLQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGGSGSAPGTPTTTSSMVLPPFPSPISGGASNDGDSGTLMRPPSRPSSTISNHSHSSQDGIGGGSGNSGDAVAGSTPAVASMASMMMMNAMSAAAGGGQSPASTGGSLPLDSTSTQQLIAALAAKSGVLPPPPPNNLLNNHHSNHLNNHVVGGAAALNNLPSPASVSVHLVKSPAPSPLPFASPHSNASTTHAAGAAGLDDDLMDEALIGIGSK
Length1933
PositionMiddle
OrganismAnopheles coluzzii
KingdomMetazoa
Lineage
Aromaticity0.02
Grand average of hydropathy-0.288
Instability index54.56
Isoelectric point9.23
Molecular weight186948.78
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07938
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|    1577.85|     160|     160|    1503|    1662|       1
---------------------------------------------------------------------------
  395-  520 (157.75/26.08)	KPNVLG.SSTVS...SGGAGG......G.P..........GGG...........G...GGG.G......G....AG....G....ATPGLNN......G...GD.GTG.PAgGGLTGSGDDGTMNGFNLSSL.GG.....................................PGPA....VDGSGAGGGG..........GSAAT......NG.TAAAQQQRG......LMN...............................GE....GNgltMS.G.GG.......SLG............LD.F.CDMLTE
  521-  658 (109.14/14.79)	RNGSGL.GAAAAigiVGGRAP......G.G..........LGA...........R...EPP.E......PlaggAAKKRRMedfcKSPKSDS......N...LSVGGG.G......................GGGACDAVGT.....EKANT....................GAAG....VAGATGATSS......ssttTTTITsqdvgaAA.SGATGAGNS.SEQ...........................................R...LQtGGAT.......EED............TG..GLP.LFG
  659-  776 (90.07/10.36)	ETVPAA.AGTDA...KGSSLG......G.T..........TTT...........NamiSAKnE......P........................................................................................................PS....V.LPMG.GGD..........GDTAT......GA.TMPLQSSSS.SSLSSLSSAgFSLA............ggPLAGEP....APDRpcpGT...L...LLE.......SLDfsalepdaakrsTG.AAQPTKRR
  777-  932 (137.49/21.37)	RSSSSS.SSSSS...SSSSSS......S.S..........SSS...........T...SA..............ASDELEE....SVDLVEAemssffA...ETNNTQ.PV.AAIAK.APFGSPSGK...PALGAVSPIASK.....VVSPS....................GGAG....LEKTPLPTIS..........GSGLE..iiplAT.SAGTVAASGfPSPSVTSAP.IAV....................PqsnaTGST...SS...TT.ATSS.......STV............KK.......SS
  933- 1058 (174.25/29.91)	SSSGGG.SGS.H...RKTSDS......S.E..........RTS...........S...SKS.E.............KKKKR....KTD..........D...SAMG...PP.NKLPYKS.SGESSPHRSGGGVGGSSLSTSK.....SSPKH....................SSPV....HHSSPKHSGS............................GGPLG.FHSPKHGSS.VSP..................KHP....LHSG...GS...ST.GGGK............................PSMSA
 1059- 1216 (125.93/18.69)	LKSAAA.SGS.S...PGSKSSdvggggG.SggtsgasistAGS...........S...SKE.R......D....KERSEKK....ALQFGTA......N...TATGSS.S....LTATSAAGSSSS...SSSGGRSKNSSLKlkqldLAAGS.....................SMS....ISMAAGIGDA................................G.SSS.....P.VAPMidltgpvpgaaaalGGLGLP....GPGM...TT........AS.......SM..................LQALQA
 1217- 1366 (105.10/13.85)	AKNRKT.T.TAA...GGS..T......G.L..........GGSlsavidklksaQ...SAD.DeavlilP....EMTITQQ....TTSLAAG......T...GGIGTGvNI.GGFGGLKDSSKSG....SGLL................PSG....................GTSSlancVSSTAGIAGAaltqsssvtsAPSLT......AAlTS......G.KASEYMVKP.SS............................................D.......GIK............LT.IQNKKGSN
 1367- 1473 (117.17/16.65)	KSSSSN.SGSGS...KSSNKS......GlK..........SGV...........S...SG.........P....VSSKQQQ....QQQ..........Q...QQQQSN.HT.TSFSGAFPSSTKSPHYTS......STSGSS.....KAPFQ....................KSNS....FGSLGGSGGT...........................................................................................gmkaskvSSP............KS.TSNPA..S
 1474- 1562 (134.08/20.58)	SSSSSA.YSSKE...KGGSTS......G.R..........SKS...........S...SAS........................................................................................................................................sltGTMLT......GA.TGGTGSGTG.SSSSALVNP.ISIM..............KMLGYP....TGSM...GN...ME.GFAK.......SLD............TK.FQIPKLSA
 1563- 1701 (205.39/37.15)	RSNSGA.TGTAS...TGSSES......G.E..........AGS...........K...SAK.D......P....AARKQKQ....QTPVTTA......A...PSVGSS.PV.RQFSSTSPSGEASARLLSDLLGAAAKSSNK.....MAPGT....................GAAS....VDGTAGAGGS.........................GGAG.......LHPLL.P.NIVQ..............KMFG........SD...GS...LQ.TKSN.......SSD............GSmF..P.TAG
 1702- 1812 (142.54/22.54)	RASPGMlSGSAS...RDGFRS......G............GGS...........G...SA.........P....G...........TPTTTS......SmvlPPF.PS.PI.S..GGASNDGDSGT.....LMRPPSRPSST.....IS.NH....................SHSS....QDGI....G......................GG.SGNSGDAVA.GSTPAVASM.ASMM...............M....................MN.A.................................MSA
 1813- 1932 (78.95/ 7.77)	AAGGGQ.S.PAS...TGGSLP......L.D............S...........T...ST....................Q....QLIAALA......A...KS.GVL.P..PPPPNNLLNNHHSNHLNNHVVGGAAALNNL.....PSPASvsvhlvkspapsplpfasphSNAS....TTHAAGAAGL.........dDDLMD......EA.LIGIGS..............................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.88|      18|      20|     203|     221|       4
---------------------------------------------------------------------------
  203-  221 (26.16/20.13)	HASAGSVTD...LaKGLLVS.LP
  223-  244 (26.72/15.41)	QYHCYFLTDnpsL.RGMMVSsIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.24|      21|      22|     262|     282|       6
---------------------------------------------------------------------------
  262-  282 (38.32/18.63)	AVFNQLL.SSCIRTNAPGGGGG
  285-  306 (31.92/14.11)	SALQQLLdGGSVHTIENGTTGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.03|      11|      15|     165|     175|       7
---------------------------------------------------------------------------
  165-  175 (20.07/ 6.88)	RAIRGIVGGSG
  181-  191 (20.96/ 7.64)	QAGEGSSGGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.64|      22|      27|     339|     360|       9
---------------------------------------------------------------------------
  339-  360 (37.29/25.35)	LQNIANIAVRIYCSEGETSDEH
  369-  390 (39.34/27.13)	LQRCMSIPVTLRALMKAWEEEH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07938 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSALEPDAAKRSTGAAQPTKRRRSSSSSSSSSSSSSSSSSSSSSTSAASDELEES
2) GRAPGGLGAREPPEPLAGGAAKKRRMEDFCKSPKSDSN
3) HEQKFKPNVLGSSTVSSGGAGGGPGGGGGGGGGAGGATPGLNNGGDGTGPAGGGLTGSGDDGTMNGFNLSSLGGPGPAVDGSGAGGGGGSAATNGTAAAQQQRGLMNGEGNGLT
4) IAALAAKSGVLPPPPPNNLLNNHHSNHLNNHVVGGAAALN
5) KPSSDGIKLTIQNKKGSNKSSSSNSGSGSKSSNKSGLKSGVSSGPVSSKQQQQQQQQQQQSNHTTSFSGAFPSSTKSPHYTSSTSGSSKAPFQKSNSFGSLGGSGGTGMKASKVSSPKSTSNPASSSSSSAYSSKEKGGSTSGRSKSSSASSLTGTMLTGATGGTGSGTGSSSSAL
6) MANGGGGGSGGPGGGPGGGKGIGKPDIKPPGGGGPSAGGTGTAGKVLLG
7) NPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNSGATGTASTGSSESGEAGSKSAKDPAARKQKQQTPVTTAAPSVGSSPVRQFSSTSPSGEASARLLSDLLGAAAKSSNKMAPGTGAASVDGTAGAGGSGGAGLHPLLPNIVQKMFGSDGSLQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGGSGSAPGTPTTTSSMVLPPFPSPISGGASNDGDSGTLMRPPSRPSSTISNHSHSSQDGIGGGSGNSGDAVAGSTPAVASMASMMMMNAMSAAAGGGQSPASTGGSLPLDSTSTQQ
8) PSGKPALGAVSPIASKVVSPSGGAGLEKTPLPTISGSGLEIIPL
9) SVGGGGGGGACDAVGTEKANTGAAGVAGATGATSSSSTTTTTITSQDVGAAASGATGAGNSSEQRLQTGGATEEDTGGLPLFGETVPAAAGTDAKGSSLGGTTTTNAMISAKNEPPSVLPMGGGDGDTATGATMPLQSSSSSSLSSLSSAGFSLAGGPLAGEPAPDRPCPGTLLLESL
10) SVSVHLVKSPAPSPLPFASPHSNASTTHAAGAAGL
11) TSAGTVAASGFPSPSVTSAPIAVPQSNATGSTSSTTATSSSTVKKSSSSSGGGSGSHRKTSDSSERTSSSKSEKKKKRKTDDSAMGPPNKLPYKSSGESSPHRSGGGVGGSSLSTSKSSPKHSSPVHHSSPKHSGSGGPLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDVGGGGGSGGTSGASISTAGSSSKERDKERSEKKALQFGTANTATGSSSLTATSAAGSSSSSSSGGRSKNSSLKLK
755
537
390
1838
1349
19
1526
841
576
1884
886
809
574
503
1877
1524
67
1836
884
753
1918
1150










Molecular Recognition Features






MoRF SequenceStartStop




1) AKKRRM
2) GGKGIGKPDIKPP
3) LKLKQLDL
4) RLLSDLLG
5) SALKSAA
557
36
1147
1628
1057
562
48
1154
1635
1063