<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07938

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSASGTAAVSGGSLPALLMANGGGGGSGGPGGGPGGGKGIGKPDIKPPGGGGPSAGGTGTAGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFQEIVAVVLEASSANKLQIQPLLVVNAGSGSAASVLQPVYTPIEKHNSTSLPATFVLRLSKPMPLNSAMMRAIRGIVGGSGAGEQQQAGEGSSGGGGLPGSLLGLIAHHASAGSVTDLAKGLLVSLPDQYHCYFLTDNPSLRGMMVSSIPFTEPQHVPKILTYLRQQAVFNQLLSSCIRTNAPGGGGGRPSALQQLLDGGSVHTIENGTTGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANIAVRIYCSEGETSDEHTVERISAVLQRCMSIPVTLRALMKAWEEEHEQKFKPNVLGSSTVSSGGAGGGPGGGGGGGGGAGGATPGLNNGGDGTGPAGGGLTGSGDDGTMNGFNLSSLGGPGPAVDGSGAGGGGGSAATNGTAAAQQQRGLMNGEGNGLTMSGGGSLGLDFCDMLTERNGSGLGAAAAIGIVGGRAPGGLGAREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVGGGGGGGACDAVGTEKANTGAAGVAGATGATSSSSTTTTTITSQDVGAAASGATGAGNSSEQRLQTGGATEEDTGGLPLFGETVPAAAGTDAKGSSLGGTTTTNAMISAKNEPPSVLPMGGGDGDTATGATMPLQSSSSSSLSSLSSAGFSLAGGPLAGEPAPDRPCPGTLLLESLDFSALEPDAAKRSTGAAQPTKRRRSSSSSSSSSSSSSSSSSSSSSTSAASDELEESVDLVEAEMSSFFAETNNTQPVAAIAKAPFGSPSGKPALGAVSPIASKVVSPSGGAGLEKTPLPTISGSGLEIIPLATSAGTVAASGFPSPSVTSAPIAVPQSNATGSTSSTTATSSSTVKKSSSSSGGGSGSHRKTSDSSERTSSSKSEKKKKRKTDDSAMGPPNKLPYKSSGESSPHRSGGGVGGSSLSTSKSSPKHSSPVHHSSPKHSGSGGPLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDVGGGGGSGGTSGASISTAGSSSKERDKERSEKKALQFGTANTATGSSSLTATSAAGSSSSSSSGGRSKNSSLKLKQLDLAAGSSMSISMAAGIGDAGSSSPVAPMIDLTGPVPGAAAALGGLGLPGPGMTTASSMLQALQAAKNRKTTTAAGGSTGLGGSLSAVIDKLKSAQSADDEAVLILPEMTITQQTTSLAAGTGGIGTGVNIGGFGGLKDSSKSGSGLLPSGGTSSLANCVSSTAGIAGAALTQSSSVTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSNKSSSSNSGSGSKSSNKSGLKSGVSSGPVSSKQQQQQQQQQQQSNHTTSFSGAFPSSTKSPHYTSSTSGSSKAPFQKSNSFGSLGGSGGTGMKASKVSSPKSTSNPASSSSSSAYSSKEKGGSTSGRSKSSSASSLTGTMLTGATGGTGSGTGSSSSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNSGATGTASTGSSESGEAGSKSAKDPAARKQKQQTPVTTAAPSVGSSPVRQFSSTSPSGEASARLLSDLLGAAAKSSNKMAPGTGAASVDGTAGAGGSGGAGLHPLLPNIVQKMFGSDGSLQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGGSGSAPGTPTTTSSMVLPPFPSPISGGASNDGDSGTLMRPPSRPSSTISNHSHSSQDGIGGGSGNSGDAVAGSTPAVASMASMMMMNAMSAAAGGGQSPASTGGSLPLDSTSTQQLIAALAAKSGVLPPPPPNNLLNNHHSNHLNNHVVGGAAALNNLPSPASVSVHLVKSPAPSPLPFASPHSNASTTHAAGAAGLDDDLMDEALIGIGSK
Length1933
PositionMiddle
OrganismAnopheles coluzzii
KingdomMetazoa
Lineage
Aromaticity0.02
Grand average of hydropathy-0.288
Instability index54.56
Isoelectric point9.23
Molecular weight186948.78
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07938
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|    1577.85|     160|     160|    1503|    1662|       1
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  395-  520 (157.75/26.08)	KPNVLG.SSTVS...SGGAGG......G.P..........GGG...........G...GGG.G......G....AG....G....ATPGLNN......G...GD.GTG.PAgGGLTGSGDDGTMNGFNLSSL.GG.....................................PGPA....VDGSGAGGGG..........GSAAT......NG.TAAAQQQRG......LMN...............................GE....GNgltMS.G.GG.......SLG............LD.F.CDMLTE
  521-  658 (109.14/14.79)	RNGSGL.GAAAAigiVGGRAP......G.G..........LGA...........R...EPP.E......PlaggAAKKRRMedfcKSPKSDS......N...LSVGGG.G......................GGGACDAVGT.....EKANT....................GAAG....VAGATGATSS......ssttTTTITsqdvgaAA.SGATGAGNS.SEQ...........................................R...LQtGGAT.......EED............TG..GLP.LFG
  659-  776 (90.07/10.36)	ETVPAA.AGTDA...KGSSLG......G.T..........TTT...........NamiSAKnE......P........................................................................................................PS....V.LPMG.GGD..........GDTAT......GA.TMPLQSSSS.SSLSSLSSAgFSLA............ggPLAGEP....APDRpcpGT...L...LLE.......SLDfsalepdaakrsTG.AAQPTKRR
  777-  932 (137.49/21.37)	RSSSSS.SSSSS...SSSSSS......S.S..........SSS...........T...SA..............ASDELEE....SVDLVEAemssffA...ETNNTQ.PV.AAIAK.APFGSPSGK...PALGAVSPIASK.....VVSPS....................GGAG....LEKTPLPTIS..........GSGLE..iiplAT.SAGTVAASGfPSPSVTSAP.IAV....................PqsnaTGST...SS...TT.ATSS.......STV............KK.......SS
  933- 1058 (174.25/29.91)	SSSGGG.SGS.H...RKTSDS......S.E..........RTS...........S...SKS.E.............KKKKR....KTD..........D...SAMG...PP.NKLPYKS.SGESSPHRSGGGVGGSSLSTSK.....SSPKH....................SSPV....HHSSPKHSGS............................GGPLG.FHSPKHGSS.VSP..................KHP....LHSG...GS...ST.GGGK............................PSMSA
 1059- 1216 (125.93/18.69)	LKSAAA.SGS.S...PGSKSSdvggggG.SggtsgasistAGS...........S...SKE.R......D....KERSEKK....ALQFGTA......N...TATGSS.S....LTATSAAGSSSS...SSSGGRSKNSSLKlkqldLAAGS.....................SMS....ISMAAGIGDA................................G.SSS.....P.VAPMidltgpvpgaaaalGGLGLP....GPGM...TT........AS.......SM..................LQALQA
 1217- 1366 (105.10/13.85)	AKNRKT.T.TAA...GGS..T......G.L..........GGSlsavidklksaQ...SAD.DeavlilP....EMTITQQ....TTSLAAG......T...GGIGTGvNI.GGFGGLKDSSKSG....SGLL................PSG....................GTSSlancVSSTAGIAGAaltqsssvtsAPSLT......AAlTS......G.KASEYMVKP.SS............................................D.......GIK............LT.IQNKKGSN
 1367- 1473 (117.17/16.65)	KSSSSN.SGSGS...KSSNKS......GlK..........SGV...........S...SG.........P....VSSKQQQ....QQQ..........Q...QQQQSN.HT.TSFSGAFPSSTKSPHYTS......STSGSS.....KAPFQ....................KSNS....FGSLGGSGGT...........................................................................................gmkaskvSSP............KS.TSNPA..S
 1474- 1562 (134.08/20.58)	SSSSSA.YSSKE...KGGSTS......G.R..........SKS...........S...SAS........................................................................................................................................sltGTMLT......GA.TGGTGSGTG.SSSSALVNP.ISIM..............KMLGYP....TGSM...GN...ME.GFAK.......SLD............TK.FQIPKLSA
 1563- 1701 (205.39/37.15)	RSNSGA.TGTAS...TGSSES......G.E..........AGS...........K...SAK.D......P....AARKQKQ....QTPVTTA......A...PSVGSS.PV.RQFSSTSPSGEASARLLSDLLGAAAKSSNK.....MAPGT....................GAAS....VDGTAGAGGS.........................GGAG.......LHPLL.P.NIVQ..............KMFG........SD...GS...LQ.TKSN.......SSD............GSmF..P.TAG
 1702- 1812 (142.54/22.54)	RASPGMlSGSAS...RDGFRS......G............GGS...........G...SA.........P....G...........TPTTTS......SmvlPPF.PS.PI.S..GGASNDGDSGT.....LMRPPSRPSST.....IS.NH....................SHSS....QDGI....G......................GG.SGNSGDAVA.GSTPAVASM.ASMM...............M....................MN.A.................................MSA
 1813- 1932 (78.95/ 7.77)	AAGGGQ.S.PAS...TGGSLP......L.D............S...........T...ST....................Q....QLIAALA......A...KS.GVL.P..PPPPNNLLNNHHSNHLNNHVVGGAAALNNL.....PSPASvsvhlvkspapsplpfasphSNAS....TTHAAGAAGL.........dDDLMD......EA.LIGIGS..............................................................................................
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.88|      18|      20|     203|     221|       4
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  203-  221 (26.16/20.13)	HASAGSVTD...LaKGLLVS.LP
  223-  244 (26.72/15.41)	QYHCYFLTDnpsL.RGMMVSsIP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.24|      21|      22|     262|     282|       6
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  262-  282 (38.32/18.63)	AVFNQLL.SSCIRTNAPGGGGG
  285-  306 (31.92/14.11)	SALQQLLdGGSVHTIENGTTGG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.03|      11|      15|     165|     175|       7
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  165-  175 (20.07/ 6.88)	RAIRGIVGGSG
  181-  191 (20.96/ 7.64)	QAGEGSSGGGG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.64|      22|      27|     339|     360|       9
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  339-  360 (37.29/25.35)	LQNIANIAVRIYCSEGETSDEH
  369-  390 (39.34/27.13)	LQRCMSIPVTLRALMKAWEEEH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07938 with Med1 domain of Kingdom Metazoa
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