<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07936

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSADLRIVKLFEEVVEDRNIVPNFDEEEQRKKTEEGYKKIGTLFGAMAPESKEAAIRNYLGYVASVNHQNRVHNYLQVMNRMVALNIIPAKLLCDQLMCSEKLVYKNPCFWIEAFRLIRKVIGGVDYKGVREIMKCCKEKALSFPASVSVNILPQLLELVELIEHIFNRNACLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSAMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDEELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMECSEKEAAQGGQGAAGGTGMNEHEGDQSHTQWIWLHLSSQLIYFVLFQFATFQNIVNTLHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKEPLPVPDNNNPNCTHQMAPTCIWIHLMKRAQTENYNINRPVPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMVGGGQPLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYVSEPKPPGNIVSGESEELNRALILTLARSMHITGTGNDPQSSAWCKDLLQNIMVNTPHAWPQHTLYCFPPVLNEFFMQHNIPKESKQLLKKTVDEEYRNWASMTNENDIIAHFGMTVNPPLFLCLVFKMIIETDGISPVAYKILERIGARALSTHLRKMCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIITIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTTEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPSLPVYFGNVCLRFLPVLDIIVHRYLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWALTEAYQAYMMTKESDNVNWVPELSYYINLVPMDGKNIFAGTDWRFNEFPNPPAHALYVTCVELLGLPVGPSVVANSIIDVLVKGYPVVPNGVIHNWANTIGLIMAALPEAYWSVIYERMQEALSSKAMKDWTYRQSPFDMFNFKIVKEAMLDRSYVTVLAIVHSIFHHFGIGQLATITDSIKEKLKPLVHTEYQLIYLCHVVGPFLHRLSIERARAVADITLMLYELLEQVDKAQPAQPLRYMDPICDLLYHIKYMFVGDTMKTELEAIIRRLRPALQMRLRFITRLNVEEIGVDQNAAAATGGGGGAGSAATAPGQGVAGAGPGVGPPPGGVAAGAPGATQGVVASGQAAPGTAAGPQQPQQVVGVVGNQNVALQQQLQQQQMGQGIQSHH
Length1447
PositionTail
OrganismAnopheles coluzzii
KingdomMetazoa
Lineage
Aromaticity0.09
Grand average of hydropathy-0.092
Instability index45.67
Isoelectric point7.33
Molecular weight163857.90
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07936
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.43|      14|      17|    1358|    1373|       1
---------------------------------------------------------------------------
 1358- 1371 (28.67/11.74)	GGGGGAGS.....AATAPG
 1376- 1394 (23.76/11.57)	GAGPGVGPppggvAAGAPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.19|      15|      17|    1116|    1130|       2
---------------------------------------------------------------------------
 1116- 1130 (26.56/16.19)	VELL..GLPVGPS.VVAN
 1133- 1150 (19.63/ 9.86)	IDVLvkGYPVVPNgVIHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     796.04|     266|     321|     468|     786|       3
---------------------------------------------------------------------------
  410-  523 (88.43/34.60)	............................................................................................................................................................................................................................................LYDILY......PEKEP......LPvPDNNNPNCTHQMAPTCiwIHLMKRAQTE..NYNiNrpvpialrlhfEYLQHLA.MPSNNPTLFMGSEYRFALLCNA.....YS..TQTDYFSRPMQALIDTILGNSKNPQ
  524-  842 (369.42/330.58)	ANmVGGGQPLPtaplsmRVLDslTIHS.....KMSLIHSIVMHMIKQaqnksSIpNGNNMAPALVETYSRLLVYTEIESlGIKGFLGQLLPQVFKSQAWgilytllemfsyrmHHIHSHYRVQLLTHLHSLASVPHTNqmqLHSCVESTALRL.....IIGLGSVEVQAQLSR............YVSEPKPpgnivsgeseelnralILTLARSMHITGT..GNDPQssaWCKDLLQNIMVN....TPHAWPQHTLYcFP.PVLNEFFMQHNIPKES..KQLLKKTVDE..EYR.N...wasmtnenDIIAHFG.M.TVNPPLF.........LCLV.....FKmiIETDGISPVAYKILERIGARALSTH
  855- 1114 (338.19/206.43)	AN.SGGGAHVN......KCVD..TINDmiwkyNIITIDRLVLCLILR.....TL.DGNEAQVSFYIIQLLLLKTTEFRN.RVQEFITINSPEHWKQNNW..............HERHLAFHQKFPEKFAPDESVSHPS...LPVYFGNVCLRFlpvldIIVHRYLEVPTQLSKtldvildhlgslYKFHDRP................ITYLYNTLHYYERklRDRPQ...LKKRLVGTVVGSlkdvRPENWALTEAY.......QAYMM....TKES..DNV..NWVPElsYYI.N..................lVPMDGKNIFAGTDWRFNEFPNPpahalYV..T........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.96|      15|      15|      45|      59|       4
---------------------------------------------------------------------------
   45-   59 (25.54/17.89)	GAMAPESKEAAIRNY
   61-   75 (27.41/19.82)	GYVASVNHQNRVHNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.06|      14|      44|     330|     344|       7
---------------------------------------------------------------------------
  330-  344 (24.75/20.33)	NEHEGdQSHTQWIWL
  376-  389 (27.31/16.84)	NLRRG.RDHLMWVFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07936 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAATGGGGGAGSAATAPGQGVAGAGPGVGPPPGGVAAGAPGATQGVVASGQAAPGTAAGPQQPQQVVGVV
1353
1423










Molecular Recognition Features






MoRF SequenceStartStop




NANANA